{"title":"Literature Highlights in Combinatorial Science: QSAR Comb. Sci. 9/2005.","authors":"","doi":"10.1002/qsar.200590050","DOIUrl":null,"url":null,"abstract":"Title: Heterogeneous hydrogenation reactions using a continuous flow high pressure device. Authors: Desai, B.; Kappe, C. O.* Graz University, Austria Source: J. Comb. Chem. 2005, 7, 641 – 643 Significance: A 'H-cube* apparatus was used in heterogeneous hydrogenation under continuous flow conditions. With dihydropyrimidines obtained from the Biginelli condensation, nitro reduction, benzyl ester deprotection and Raney nickel desulfurization were all demonstrated. Products were prepared in > 100 mg scale in 30 minutes.","PeriodicalId":49134,"journal":{"name":"Quantitative Structure-Activity Relationships & Combinatorial Science","volume":"24 9","pages":"1117-1121"},"PeriodicalIF":0.0000,"publicationDate":"2005-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/qsar.200590050","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Quantitative Structure-Activity Relationships & Combinatorial Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/qsar.200590050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2005/11/22 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Title: Heterogeneous hydrogenation reactions using a continuous flow high pressure device. Authors: Desai, B.; Kappe, C. O.* Graz University, Austria Source: J. Comb. Chem. 2005, 7, 641 – 643 Significance: A 'H-cube* apparatus was used in heterogeneous hydrogenation under continuous flow conditions. With dihydropyrimidines obtained from the Biginelli condensation, nitro reduction, benzyl ester deprotection and Raney nickel desulfurization were all demonstrated. Products were prepared in > 100 mg scale in 30 minutes.
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