Fabrication of a novel hydroxyapatite/polyether ether ketone surface nanocomposite via friction stir processing for orthopedic and dental applications.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2020-06-01 Epub Date: 2020-05-03 DOI:10.1007/s40204-020-00130-7
Davood Almasi, Woei Jye Lau, Sajad Rasaee, Roohollah Sharifi, Hamid Reza Mozaffari
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引用次数: 13

Abstract

There is increasing interest in the use of polyether ether ketone (PEEK) for orthopedic and dental implant applications due to its elastic modulus (close to that of bone), biocompatibility and radiolucent properties. However, PEEK is still categorized as bioinert owing to its low integration with surrounding tissues. Methods such as depositing hydroxyapatite (HA) onto the PEEK surface could increase its bioactivity. However, depositing HA without damaging the PEEK substrate is still required further investigation. Friction stir processing is a solid-state processing method that is widely used for composite substrate fabrication. In this study, a pinless tool was used to fabricate a HA/PEEK surface nanocomposite for orthopedic and dental applications. Microscopical images of the modified substrate confirmed homogenous distribution of the HA on the surface of the PEEK. The resultant HA/PEEK surface nanocomposites demonstrated improved surface hydrophilicity coupled with better apatite formation capacity (as shown in the simulated body fluid) in comparison to the pristine PEEK, making the newly developed material more suitable for biomedical application. This surface deposition method that is carried out at low temperature would not damage the PEEK substrate and thus could be a good alternative for existing commercial methods for PEEK surface modification.

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一种新型羟基磷灰石/聚醚醚酮表面纳米复合材料的制备及其在骨科和牙科领域的应用。
聚醚醚酮(PEEK)由于其弹性模量(接近骨的弹性模量)、生物相容性和放射性,越来越多的人对其在骨科和牙科植入物中的应用感兴趣。然而,PEEK仍然被归类为生物惰性,因为它与周围组织的结合度很低。在PEEK表面沉积羟基磷灰石(HA)等方法可以提高其生物活性。然而,在不破坏PEEK基板的情况下沉积HA仍然需要进一步的研究。搅拌摩擦加工是一种广泛应用于复合材料基板制造的固态加工方法。在这项研究中,使用无针工具制造了用于骨科和牙科应用的HA/PEEK表面纳米复合材料。改性基板的显微图像证实了HA在PEEK表面的均匀分布。与原始PEEK相比,合成的HA/PEEK表面纳米复合材料表现出更好的表面亲水性和更好的磷灰石形成能力(如模拟体液所示),使新开发的材料更适合生物医学应用。这种在低温下进行的表面沉积方法不会损坏PEEK基材,因此可以作为现有的用于PEEK表面改性的商业方法的一个很好的替代方法。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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