Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2023-06-01 DOI:10.1007/s40204-023-00219-9
Leena V Hublikar, Sharanabasava V Ganachari, Veerabhadragouda B Patil, Sahana Nandi, Aishwarya Honnad
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引用次数: 6

Abstract

A Lantana camara leaf (LC) extract was used as a mild reducing agent to produce silver metal nanoparticles (LC-AgNPs) efficiently. The size, shape, and morphology of synthesized silver nanoparticles were verified. LC-AgNPs were found in LC extract by XRD. The optimal concentrations of silver nitrate and LC extract necessary for the production of stable silver nanoparticles were determined. The LC-AgNPs were found spherical in form and monodispersed. Under optimal conditions, the round LC-AgNPs of 50-90 nm were utilized to cure lung cancer (A549 cell line) and breast cancer (MCF7) cell lines. Finally, the produced LC-AgNPs enhanced anti-cancer efficacy against A549 cells, with an IC50 = 49.52 g/mL. Similarly, the effect of LC-AgNPs on MCF7 cell line was assessed using an MTT test and inhibitory concentration (IC50) was determined found that 46.67 g/mL.

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生物合成银纳米颗粒的抗癌潜力。
以大灯笼叶(LC)提取物为温和还原剂,高效制备金属银纳米颗粒(LC- agnps)。对合成的银纳米粒子的大小、形状和形貌进行了验证。通过XRD在LC萃取物中发现了LC- agnps。确定了制备稳定的纳米银所需的硝酸银和LC萃取物的最佳浓度。LC-AgNPs呈球形,单分散。在最佳条件下,将50 ~ 90 nm的圆形LC-AgNPs用于肺癌(A549细胞系)和乳腺癌(MCF7)细胞系的治疗。最后,LC-AgNPs增强了对A549细胞的抗癌作用,IC50 = 49.52 g/mL。同样,采用MTT法测定LC-AgNPs对MCF7细胞株的抑制浓度(IC50)为46.67 g/mL。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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