Infección fúngica sinusal por Schizophyllum commune: a propósito de dos casos clínicos

IF 1.5 4区生物学 Q4 MYCOLOGY Revista Iberoamericana De Micologia Pub Date : 2020-04-01 DOI:10.1016/j.riam.2020.02.004

Belén Fernández-Caso , Arturo Manuel Fraile , Marta Soledad Rodríguez , Inmaculada Fernández , Buenaventura Buendía

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Abstract

Background

Schizophyllum commune is a basidiomycete fungus which is widely distributed in nature. Its role as responsible for disease in humans is not well known, partly due to its difficult identification. The incorporation of mass spectrometry techniques (MALDI-TOF) and molecular biology to the laboratories has allowed the description of a greater number of cases.

Case report

In this paper, we present two cases in which S. commune was identified as the causative agent of disease: in the first case an immunocompetent patient suffered from chronic rhinosinusitis, and in the second one a sphenoid sinus infection was diagnosed in an immunocompromised patient. In both cases, S. commune was isolated. Its identification was possible by means of MALDI-TOF and this was confirmed in both patients by amplification and sequencing of the ITS region.

Conclusions

In conclusion, S. commune should be considered a potential causative agent of fungal disease. Currently, MALDI-TOF and sequencing techniques are necessary for its identification.

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常见裂叶菌鼻窦真菌感染:两例临床病例的综述

裂叶菌(schizophyllum commune)是一种广泛分布于自然界的担子真菌。它在人类疾病中的作用尚不清楚，部分原因是它难以识别。将质谱分析技术(MALDI-TOF)和分子生物学结合到实验室，可以对更多的病例进行描述。在这篇论文中，我们提出了两例被确定为疾病病原体的S. commune:在第一例中，一名免疫功能正常的患者患有慢性鼻窦炎，在第二例中，一名免疫功能低下的患者被诊断为蝶窦感染。在这两种情况下，S. commune都被隔离。可以通过MALDI-TOF进行鉴定，并通过Its区域的扩增和测序在两例患者中得到证实。结论:该菌为真菌病的潜在病原。目前，需要利用MALDI-TOF和测序技术进行鉴定。

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来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.