Symposium summary: Epigenetic inheritance-impact for biology and society 26-28 August 2019, Zurich, Switzerland.

IF 4.8 Q1 GENETICS & HEREDITY Environmental Epigenetics Pub Date : 2020-05-06 eCollection Date: 2020-01-01 DOI:10.1093/eep/dvaa004
Irina Lazar-Contes, Martin Roszkowski, Deepak K Tanwar, Isabelle M Mansuy
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引用次数: 2

Abstract

The concept of epigenetic inheritance proposes a new and unconventional way to think about heredity in health and disease, at the interface between genetics and the environment. Epigenetic inheritance is a form of biological inheritance not encoded in the DNA sequence itself but mediated by epigenetic factors. Because epigenetic factors can be modulated by the environment, they can relay this information to the genome and modify its activity consequentially. If epigenetic changes induced by environmental exposure are present in the germline and persist in germ cells during development until conception, they have the potential to transfer the traces of ancestral exposure to the progeny. This form of heredity relates to the extremely important question of nature versus nurture and how much of our own make-up is genetically or epigenetically determined, a question that remains largely unresolved. Because it questions the dominant dogma of genetics and brings a paradigm shift in sciences, it has to creating strong bridges between disciplines and provide solid causal evidence to be firmly established. The second edition of a conference fully dedicated to epigenetic inheritance was held in August 2019 in Zurich, Switzerland. This symposium titled 'Epigenetic inheritance: impact for biology and society' (http://www.epigenetic-inheritance-zurich.ethz.ch), gathered experts in the field of epigenetic inheritance to discuss the concept and pertinent findings, exchange views and expertise about models and methods, and address challenges raised by this new discipline. The symposium offered a mix of invited lectures and short talks selected from abstracts, poster sessions and a workshop 'Meet the experts: Q&A'. A tour of a local omics facility the Functional Genomics Center Zurich was also offered to interested participants. Additional comments and impressions were shared by attendees on Twitter #eisz19 during and after the symposium. This summary provides an overview of the different sessions and talks and describes the main findings presented.

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2019年8月26-28日,瑞士苏黎世,表观遗传对生物学和社会的影响
表观遗传的概念提出了一种新的和非传统的方式来思考健康和疾病中的遗传,在遗传学和环境之间的接口。表观遗传是一种不以DNA序列本身编码,而是由表观遗传因子介导的生物遗传形式。由于表观遗传因素可以被环境调节,它们可以将这些信息传递给基因组并相应地改变其活性。如果由环境暴露引起的表观遗传变化存在于生殖细胞中,并在发育过程中持续存在于生殖细胞中直至受孕,则它们有可能将祖先暴露的痕迹转移给后代。这种形式的遗传关系到一个极其重要的问题,即先天与后天,以及我们自身的构成有多少是由遗传或表观遗传决定的,这个问题在很大程度上仍未得到解决。因为它质疑了遗传学的主导教条,并带来了科学范式的转变,它必须在学科之间建立牢固的桥梁,并提供坚实的因果证据,才能牢固地建立起来。2019年8月,第二届专门讨论表观遗传的会议在瑞士苏黎世举行。本次研讨会题为“表观遗传:对生物学和社会的影响”(http://www.epigenetic-inheritance-zurich.ethz.ch),聚集了表观遗传领域的专家,讨论了表观遗传的概念和相关发现,交流了关于模型和方法的观点和专业知识,并解决了这一新学科提出的挑战。研讨会提供了邀请讲座和从摘要中挑选的简短演讲,海报会议和“与专家会面:问答”研讨会。有兴趣的参与者还可以参观苏黎世功能基因组学中心的当地组学设施。在研讨会期间和之后,与会者在Twitter #eisz19上分享了其他评论和印象。本摘要提供了不同会议和演讲的概述,并描述了提出的主要发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Environmental Epigenetics
Environmental Epigenetics GENETICS & HEREDITY-
CiteScore
6.50
自引率
5.30%
发文量
0
审稿时长
17 weeks
期刊最新文献
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