Roya Dolatkhah, Mohammad Hossein Somi, Mohammad Asghari Jafarabadi, Mehrnaz Hosseinalifam, Sepideh Sepahi, Mina Belalzadeh, Marzieh Nezamdoust, Saeed Dastgiri
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引用次数: 28
Abstract
Methods: Data were obtained from East Azerbaijan cancer registry database for the 10-year period between 2007 and 2016. Survival analysis was performed to calculate the breast cancer-specific survival proportions and mortality rates. Joinpoint trend analysis was performed to estimate the incidence trend of the cancer.
Results: A total number of 4989 patients were recorded with primary diagnosis of breast cancer. Of them, we collected follow-up data for 1335 (1309 female and 26 male). The 10-year crude mortality rate was 3.34 (per 100,000). The one-, two-, three-, five-, and ten-year breast cancer-specific survival proportions were 0.92 (95% CI 0.91-0.93), 0.88 (95% CI 0.86-0.90), 0.84 (95% CI 0.83-0.86), 0.77 (95% CI 0.74-0.80), and 0.65 (95% CI 0.60-0.70), respectively. Over the study period, the age-standardized incidence rates increased from 21.68 to 36.99 (per 100,000) with an annual percentage change of 5.5 percent. Older individuals and males patients had significantly worse survival, and patients with high-grade tumors had significantly higher risk of mortality.
Conclusion: A relatively better survival for breast cancer in East Azerbaijan, Iran, was observed compared to the overall breast cancer-specific survival proportions and mortality rates in the country. However, it is still poor compared to the developed countries indicating that inappropriate treatment modalities might have played a role on this.
方法:数据来自2007年至2016年东阿塞拜疆癌症登记数据库。进行生存分析,计算乳腺癌特异性生存率和死亡率。采用联合点趋势分析估计肿瘤的发病趋势。结果:本组共4989例初诊乳腺癌患者。其中,我们收集了1335例(女性1309例,男性26例)的随访资料。10年粗死亡率为3.34(每10万人)。1年、2年、3年、5年和10年乳腺癌特异性生存率分别为0.92 (95% CI 0.91-0.93)、0.88 (95% CI 0.86-0.90)、0.84 (95% CI 0.83-0.86)、0.77 (95% CI 0.74-0.80)和0.65 (95% CI 0.60-0.70)。在研究期间,年龄标准化发病率从21.68上升到36.99(每10万人),年增长率为5.5%。老年人和男性患者的生存率明显较差,恶性肿瘤患者的死亡率明显较高。结论:与该国总体乳腺癌特异性生存率和死亡率相比,观察到伊朗东阿塞拜疆的乳腺癌生存率相对较高。然而,与发达国家相比,它仍然很差,这表明不适当的治疗方式可能在这方面发挥了作用。
期刊介绍:
International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.