Intranasal Delivery of Nanotherapeutics/ Nanobiotherapeutics for the Treatment of Alzheimer's Disease: A Proficient Approach.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2019-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2018026762

Namdev L Dhas, Ritu R Kudarha, Tejal A Mehta

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引用次数: 11

Abstract

Therapeutics and biotherapeutics-based fabrication of nanoparticles has fascinated scientists since the past two decades and exciting challenges have been surmounted. Particular interest has been paid to the exploitation of functionalized nanocarriers in the treatment of Alzheimer's disease (AD) using nasal route. Development of various material-based nanocarriers is a common approach to obtain advanced drug delivery systems possessing the ability to follow intranasal (IN) route for brain targeting, which would ultimately ameliorate the effect of AD. This review highlights the various pathological theories for AD along with their controversies. This work intends to provide a thorough, up-to-date, and holistic discussion on various pathways for nose-to-brain delivery and different formulation factors impacting on nasal absorption. The various material properties and their engineered nanocarriers as a smart delivery system, including synergistic effect of therapeutic/biotherapeutic agent in IN delivery as well as in AD therapy have been discussed. This review also emphasizes toxicity, especially neurotoxicity concerns pertaining to drug delivery systems.

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鼻内给药纳米疗法/纳米生物疗法治疗阿尔茨海默病:一种熟练的方法。

在过去的二十年里，以治疗和生物治疗为基础的纳米颗粒制造一直吸引着科学家，并且已经克服了令人兴奋的挑战。特别感兴趣的是功能化纳米载体在阿尔茨海默病(AD)的鼻路治疗中的开发。开发各种基于材料的纳米载体是获得先进的药物递送系统的一种常见方法，该系统具有沿鼻内(IN)途径靶向大脑的能力，最终将改善AD的效果。本文综述了阿尔茨海默病的各种病理理论及其争议。这项工作旨在提供一个全面的，最新的，全面的讨论鼻到脑的各种途径和不同的配方因素影响鼻腔吸收。本文讨论了作为智能递送系统的各种材料特性及其工程纳米载体，包括治疗/生物治疗剂在in递送和AD治疗中的协同效应。本综述还强调毒性，特别是与药物传递系统有关的神经毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.