Discovery, bioactivity and biosynthesis of fungal piperazines

IF 10.2 1区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2023-01-01 DOI:10.1039/d2np00070a
Rui Wang , Andrew M. Piggott , Yit-Heng Chooi , Hang Li
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Abstract

Covering: up to the end of July, 2022

Fungi are prolific producers of piperazine alkaloids, which have been shown to exhibit an array of remarkable biological activities. Since the first fungal piperazine, herquline A, was reported from Penicillium herquei Fg-372 in 1979, a plethora of structurally diverse piperazines have been isolated and characterised from various fungal strains. Significant advancements have been made in recent years towards unravelling the biosynthesis of fungal piperazines and numerous synthetic routes have been proposed. This review provides a comprehensive summary of the current knowledge of the discovery, classification, bioactivity and biosynthesis of piperazine alkaloids reported from fungi, and discusses the perspectives for exploring the structural diversity of fungal piperazines via genome mining of the untapped piperazine biosynthetic pathways.

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真菌哌嗪类化合物的发现、生物活性及生物合成
报道:截至2022年7月底,丰吉是哌嗪生物碱的多产生产商,这些生物碱已被证明具有一系列显著的生物活性。自1979年从青霉菌(Penicillium herquei Fg-372)中报道第一种真菌哌嗪(herquline A)以来,已经从各种真菌菌株中分离并鉴定了大量结构多样的哌嗪。近年来,在解开真菌哌嗪的生物合成方面取得了重大进展,并提出了许多合成路线。这篇综述全面总结了真菌中哌嗪生物碱的发现、分类、生物活性和生物合成的最新知识,并讨论了通过基因组挖掘尚未开发的哌嗪生物合成途径来探索真菌哌嗪结构多样性的前景。
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来源期刊
Natural Product Reports
Natural Product Reports 化学-生化与分子生物学
CiteScore
21.20
自引率
3.40%
发文量
127
审稿时长
1.7 months
期刊介绍: Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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