Maie A Fadel, Nagwa A Kamel, Mirhane M Darwish, Salwa L Abd El-Messieh, Kamal N Abd-El-Nour, Wafaa A Khalil
{"title":"Dielectric properties and in vitro hemocompatibility of Nd:YAG laser-irradiated polyethylene terephthalate.","authors":"Maie A Fadel, Nagwa A Kamel, Mirhane M Darwish, Salwa L Abd El-Messieh, Kamal N Abd-El-Nour, Wafaa A Khalil","doi":"10.1007/s40204-020-00134-3","DOIUrl":null,"url":null,"abstract":"<p><p>Surface properties and morphology of the biomaterial play an essential role in the polymer-material interaction. In this work, laser surface modification of polyethylene terephthalate as a polymer with distinguished mechanical properties was carried out using (neodymium-doped yttrium aluminum garnet) Nd:YAG laser (1.064 µm) with different output power (0.3, 3, and 6 W). The structural, surface, and dielectric properties of PET before and after laser irradiation have been studied using attenuation total reflection-Fourier transform infrared (ATR-FTIR), dielectric spectroscopy (DS), scanning electron microscope (SEM), and contact angle measurements. Moreover, the anticoagulant properties of the laser-irradiated PET was determined through measuring the prothrombin time (PT), partial thromboplastin time (PTT), and international normalized ratio (INR). In vitro platelet adhesion test was used to assess the platelets adhered to the surface of the samples; in addition to hematological study. It was found that contact angle (θ) measurements of laser-irradiated PET samples decreased compared to the unirradiated PET. The irradiated samples at 0.3 W have the lowest contact angle which is a clear indication that surface treatment with Nd:YAG laser brought about improving the wettability of the polymer. From the dielectric measurements, both values of permittivity and dielectric loss decrease by increasing the laser power. The electrical conductivity decreases with increasing laser power, but still in the same order 10<sup>-14</sup> S/cm. The decrease in electrical conductivity σ may be due to the cross-linking of the polymeric matrix which led to a decrease in the total polarity and consequently decrease in electrical conductivity. The magnitude of σ obtained is highly recommended to be used for insulator purposes in addition to the main purpose that is blood contact.</p>","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":"9 3","pages":"107-114"},"PeriodicalIF":4.4000,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544811/pdf/40204_2020_Article_134.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Biomaterials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s40204-020-00134-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/7/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Surface properties and morphology of the biomaterial play an essential role in the polymer-material interaction. In this work, laser surface modification of polyethylene terephthalate as a polymer with distinguished mechanical properties was carried out using (neodymium-doped yttrium aluminum garnet) Nd:YAG laser (1.064 µm) with different output power (0.3, 3, and 6 W). The structural, surface, and dielectric properties of PET before and after laser irradiation have been studied using attenuation total reflection-Fourier transform infrared (ATR-FTIR), dielectric spectroscopy (DS), scanning electron microscope (SEM), and contact angle measurements. Moreover, the anticoagulant properties of the laser-irradiated PET was determined through measuring the prothrombin time (PT), partial thromboplastin time (PTT), and international normalized ratio (INR). In vitro platelet adhesion test was used to assess the platelets adhered to the surface of the samples; in addition to hematological study. It was found that contact angle (θ) measurements of laser-irradiated PET samples decreased compared to the unirradiated PET. The irradiated samples at 0.3 W have the lowest contact angle which is a clear indication that surface treatment with Nd:YAG laser brought about improving the wettability of the polymer. From the dielectric measurements, both values of permittivity and dielectric loss decrease by increasing the laser power. The electrical conductivity decreases with increasing laser power, but still in the same order 10-14 S/cm. The decrease in electrical conductivity σ may be due to the cross-linking of the polymeric matrix which led to a decrease in the total polarity and consequently decrease in electrical conductivity. The magnitude of σ obtained is highly recommended to be used for insulator purposes in addition to the main purpose that is blood contact.
生物材料的表面特性和形态在聚合物与材料的相互作用中起着至关重要的作用。在这项工作中,使用不同输出功率(0.3、3 和 6 W)的(掺钕钇铝石榴石)Nd:YAG 激光器(1.064 µm)对聚对苯二甲酸乙二醇酯这种具有优异机械性能的聚合物进行了激光表面改性。使用衰减全反射-傅立叶变换红外光谱(ATR-FTIR)、介电光谱(DS)、扫描电子显微镜(SEM)和接触角测量法研究了 PET 在激光照射前后的结构、表面和介电性质。此外,还通过测量凝血酶原时间(PT)、部分凝血活酶时间(PTT)和国际归一化比率(INR)确定了激光照射 PET 的抗凝特性。除血液学研究外,还使用体外血小板粘附试验来评估血小板在样品表面的粘附情况。研究发现,与未经过辐照的 PET 相比,经过激光辐照的 PET 样品的接触角(θ)测量值有所下降。0.3 W 的辐照样品接触角最小,这清楚地表明 Nd:YAG 激光的表面处理改善了聚合物的润湿性。从介电测量结果来看,随着激光功率的增加,介电常数和介电损耗值都会降低。电导率随激光功率的增加而降低,但仍保持在 10-14 S/cm 的数量级。电导率 σ 下降的原因可能是聚合物基质发生了交联,导致总极性降低,从而使电导率下降。除了血液接触这一主要用途外,还强烈建议将所获得的 σ 值用于绝缘体用途。
期刊介绍:
Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.