Himali P Herath, Rasika P Herath, Rajitha Wickremasinghe
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引用次数: 0
Abstract
Background: Studies of developmental origins of health and disease have highlighted the possible role of intrauterine hyperglycaemia, increasing the future risk of obesity, diabetes, and cardiovascular diseases in the offspring. There is limited evidence from South Asian populations for risk estimates for childhood obesity that are attributable to maternal diabetes in utero.
Objective: The aim of this study was to determine the association between hyperglycaemia in pregnancy (HIP) and anthropometric parameters in the offspring at 10-11 years of age.
Methods: A community-based retrospective cohort study was conducted in Colombo district, Sri Lanka. In the first stage, children born in 2005 were identified, and the availability of antenatal records was assessed. In the second stage, the exposure status of participants was ascertained based on antenatal records and predefined criteria. In the third stage, height, weight, waist circumference, and triceps skinfold thickness (TSFT) of eligible participants were measured to ascertain the outcome status. Background characteristics were collected by interviewing mothers. A 24-hour dietary recall and a 3-day diet diary were recorded.
Results: 159 children of mothers with HIP (exposed) and 253 children of mothers with no HIP (nonexposed) participated. Mean ages (SD) of exposed and unexposed groups were 10.9 (0.3) and 10.8 (0.3) years, respectively. The median BMI (17.6 vs 16.1, p < 0.001), waist circumference (63 cm vs 59.3 cm, p < 0.001), and triceps skinfold thickness (13.7 mm vs 11.2 mm, p < 0.001) were significantly higher in the exposed group. Offspring of women with HIP were more likely to be overweight (aOR = 2.6, 95% CI 1.4-4.9) and have abdominal obesity (aOR = 2.7, 95% CI 1.1-6.5) and high TSFT (aOR = 2.2, 95% CI 1.06-4.7) at 10-11 years than children who were not exposed after adjusting for maternal BMI, maternal age at delivery, and birth order.
Conclusions: Intrauterine exposure to HIP is a significant determinant of overweight, high TSFT, and abdominal obesity in the offspring.
背景:对健康和疾病的发育起源的研究强调了宫内高血糖的可能作用，增加了后代未来肥胖、糖尿病和心血管疾病的风险。在南亚人群中，由于母体在子宫内患有糖尿病而导致儿童肥胖的风险估计证据有限。目的:本研究的目的是确定妊娠期高血糖(HIP)与后代10-11岁时人体测量参数之间的关系。方法:在斯里兰卡科伦坡地区进行以社区为基础的回顾性队列研究。在第一阶段，确定了2005年出生的儿童，并评估了产前记录的可得性。在第二阶段，根据产前记录和预先确定的标准确定参与者的暴露状况。在第三阶段，测量符合条件的参与者的身高、体重、腰围和三头肌皮褶厚度(TSFT)，以确定结果状态。通过访谈母亲收集背景特征。记录24小时饮食回忆和3天饮食日记。结果:159名患有HIP的母亲的孩子(暴露)和253名没有HIP的母亲的孩子(未暴露)参与了研究。暴露组和未暴露组的平均年龄(SD)分别为10.9(0.3)和10.8(0.3)岁。暴露组的中位BMI (17.6 vs 16.1, p < 0.001)、腰围(63 cm vs 59.3 cm, p < 0.001)和肱三头肌皮褶厚度(13.7 mm vs 11.2 mm, p < 0.001)显著高于暴露组。在调整了母亲的BMI、分娩年龄和出生顺序后，HIP妇女的后代在10-11岁时比未暴露的儿童更容易超重(aOR = 2.6, 95% CI 1.4-4.9)、腹部肥胖(aOR = 2.7, 95% CI 1.1-6.5)和高TSFT (aOR = 2.2, 95% CI 1.06-4.7)。结论:宫内暴露于HIP是后代超重、高TSFT和腹部肥胖的重要决定因素。
期刊介绍：
Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
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