The expression and prognostic significance of Topo-II and c-erbB-2 in breast cancer.

IF 4.7 4区医学 0 MEDICINE, GENERAL & INTERNAL Minerva medica Pub Date : 2024-08-01 Epub Date: 2020-07-17 DOI:10.23736/S0026-4806.20.06637-9

Hua Shao, Chuanbo Feng, Zhonglin Wang, Shuangjiu Zhu, Xinwen Zheng

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Abstract

Background: This study aimed to investigate the expression and prognostic significance of topoisomeraseII (Topo-II) and c-erbB-2.

Methods: A total of 92 cases of patients with breast cancer who came to our hospital for treatment from November 2013 to January 2016 were included as the experimental group, and 90 healthy subjects who came to our hospital for physical examination during the same period were selected as the control group. ELISA was used to detect the expression levels of Topo-II and c-erbB-2 in serum of each group. The correlation among expression levels, degree of tumor differentiation and pathological types of Topo-II and c-erbB-2 in serum of patients with breast cancer were observed.

Results: The expression levels of Topo-II and c-erbB-2 in the experimental group were higher than those in the control group (P<0.05). The expression levels of Topo-II and c-erbB-2 in serum of patients with different stages increased with the clinical stages. The survival rate of patients with different expression levels of Topo-II and c-erbB-2 was compared, it was found that the survival rate of the low-expression group (80.49%) was significantly higher than that of the high-expression group (50.98%). The ROC curve was used to analyze Topo-II and c-erbB-2, the result showed that the sensitivity, specificity and AUC of Topo-II in the diagnosis of breast cancer was 72.22%, 94.56% and 0.8641, respectively. The sensitivity, specificity, and AUC of c-erbB-2 in the diagnosis of breast cancer were 94.45%, 66.30% and 0.8379, respectively.

Conclusions: In conclusion, Topo-II and c-erbB-2 are highly expressed in breast cancer and are closely related to breast cancer. Moreover, the detection of Topo-II and c-erbB-2 in serum can help diagnose gestational diabetes mellitus quickly and effectively.

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Topo-II和c-erbB-2在乳腺癌中的表达及其预后意义。

背景：本研究旨在探讨拓扑异构酶II（Topo-II）和c-erbB-2的表达及预后意义：本研究旨在探讨拓扑异构酶II（Topo-II）和c-erbB-2的表达及预后意义：选取2013年11月至2016年1月来我院就诊的92例乳腺癌患者为实验组，选取同期来我院体检的90例健康人为对照组。采用 ELISA 法检测各组血清中 Topo-II 和 c-erbB-2 的表达水平。观察Topo-II和c-erbB-2在乳腺癌患者血清中的表达水平、肿瘤分化程度和病理类型之间的相关性：结果：实验组 Topo-II 和 c-erbB-2 的表达水平高于对照组（PC）：总之，Topo-II和c-erbB-2在乳腺癌中高表达，与乳腺癌密切相关。此外，血清中 Topo-II 和 c-erbB-2 的检测有助于快速有效地诊断妊娠糖尿病。

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来源期刊

Minerva medica 医学-医学：内科

CiteScore

6.40

自引率

6.40%

发文量

358

审稿时长

>12 weeks

期刊介绍： Minerva Medica publishes scientific papers on internal medicine. Manuscripts may be submitted in the form of editorials, original articles, review articles, case reports, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work. Duties and responsibilities of all the subjects involved in the editorial process are summarized at Publication ethics.