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Predictive markers associated to fibrotic evolution in hypersensitivity pneumonitis: a single institution's analysis. 与超敏性肺炎纤维化演变相关的预测标志物:单一机构的分析。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2025-02-01 Epub Date: 2023-09-15 DOI: 10.23736/S0026-4806.23.08823-7
Francesco R Bertuccio, Valerio Partenope, Davide Piloni, Simone Montini, Nicola Baio, Chandra Bortolotto, Adele Valentini, Angelo G Corsico, Giulia M Stella
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引用次数: 0
Analysis of the effect of targeted nursing in patients with endocrine disorders and obesity. 对内分泌失调和肥胖症患者进行针对性护理的效果分析。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2025-02-01 Epub Date: 2020-07-28 DOI: 10.23736/S0026-4806.20.06844-5
Hong Xin, Hongxia Shao, Hongyan Deng
{"title":"Analysis of the effect of targeted nursing in patients with endocrine disorders and obesity.","authors":"Hong Xin, Hongxia Shao, Hongyan Deng","doi":"10.23736/S0026-4806.20.06844-5","DOIUrl":"10.23736/S0026-4806.20.06844-5","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"84-86"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38207329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed treatment with endostatin displays a protective role against pulmonary hypertension by targeting VEGF pathway. 通过靶向血管内皮生长因子通路，内司他丁延迟治疗对肺动脉高压具有保护作用。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2025-02-01 Epub Date: 2021-04-29 DOI: 10.23736/S0026-4806.21.07145-7
Shuai Huang, Nannan Li, Dong Yan

Background: Endostatin (ES) is an endogenous angiogenesis inhibitor. It is confirmed that ES has antitumor effects and plays a crucial part in regulating vascular smooth cells' proliferation. However, ES's effect on pulmonary hypertension (PH) is unclear. The aim of this study was to determine the effect of ES on PH's pathogenesis.

Methods: PH was induced by pneumonectomy plus monocrotaline (MCT) injection, as indicated with significantly increased pulmonary arterial pressure and vascular wall thickness.

Results: Immunohistochemical analysis showed that under physiological conditions, ES localized in endothelial cells (ECs) and spread to the muscular vascular layers in PH rats. ES was transfected into the lungs of rats intratracheally 2 weeks after MCT injection. Consequently, ES not only reduced elevated VEGF's expression but also reversed pulmonary artery remodeling. Eventually, ES improved elevated right ventricular (RV) mean pressure and RV hypertrophy.

Conclusions: The administration of ES may be a new treatment for PH and PA remodeling, associating with the downregulation of VEGF production.

背景：内ostatin（ES）是一种内源性血管生成抑制剂。已证实 ES 具有抗肿瘤作用，并在调节血管平滑细胞增殖方面发挥重要作用。然而，ES对肺动脉高压（PH）的影响尚不明确。我们的目的是确定 ES 对 PH 发病机制的影响：方法：通过肺切除术加注射单克隆肾上腺素（MCT）诱发肺动脉高压，肺动脉压和血管壁厚度明显增加：免疫组化分析表明，在生理条件下，ES定位于PH大鼠的内皮细胞（EC），并扩散到肌肉血管层。在注射 MCT 2 周后，将 ES 经气管内转染至大鼠肺部。结果，ES 不仅降低了血管内皮生长因子的表达，还逆转了肺动脉重塑。最终，ES 改善了右心室（RV）平均压升高和 RV 肥厚：结论：服用 ES 可能是治疗 PH 和 PA 重塑的一种新方法，它与血管内皮生长因子分泌的下调有关。
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引用次数: 0
Efficacy and safety of pars plana vitrectomy combined with internal limiting membrane peeling for macular hollow retinal detachment. 玻璃体旁切除术联合内缘膜剥离治疗黄斑空洞性视网膜脱离的有效性和安全性。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2025-02-01 Epub Date: 2020-09-03 DOI: 10.23736/S0026-4806.20.06841-X
Jinwei Ren, Min Liu, Linlin Wang, Mingtao Zhao
{"title":"Efficacy and safety of pars plana vitrectomy combined with internal limiting membrane peeling for macular hollow retinal detachment.","authors":"Jinwei Ren, Min Liu, Linlin Wang, Mingtao Zhao","doi":"10.23736/S0026-4806.20.06841-X","DOIUrl":"10.23736/S0026-4806.20.06841-X","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"83-84"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38339859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-dose corticosteroids adjusted to oxygen requirement and monitoring of serum C-reactive protein to improve outcome of non-critically ill COVID-19 patients: the CocAA-CoLa Plus Study. 根据需氧量调整大剂量皮质类固醇并监测血清c反应蛋白以改善非危重症COVID-19患者的预后:可口可乐+研究
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2025-02-01 Epub Date: 2023-05-11 DOI: 10.23736/S0026-4806.22.08326-4
Jean-Philippe Kevorkian, Claire Vandiedonck, Jean Laganier, Amanda Lopes, Ruxandra Burlacu, Florine Feron, Marie-Laure Chai X, Damien Sene, Jean-Pierre Riveline, Jean-François Gautier, Bruno Megarbane
{"title":"High-dose corticosteroids adjusted to oxygen requirement and monitoring of serum C-reactive protein to improve outcome of non-critically ill COVID-19 patients: the CocAA-CoLa Plus Study.","authors":"Jean-Philippe Kevorkian, Claire Vandiedonck, Jean Laganier, Amanda Lopes, Ruxandra Burlacu, Florine Feron, Marie-Laure Chai X, Damien Sene, Jean-Pierre Riveline, Jean-François Gautier, Bruno Megarbane","doi":"10.23736/S0026-4806.22.08326-4","DOIUrl":"10.23736/S0026-4806.22.08326-4","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"75-79"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of targeted nursing intervention on negative mental status and quality of life of elderly patients with coronary heart disease. 针对性护理干预对老年冠心病患者负面精神状态和生活质量的影响。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-12-01 Epub Date: 2020-06-22 DOI: 10.23736/S0026-4806.20.06759-2
Xiwei Chen, Ying Tian, Jing Qin, Jing Liu
{"title":"Effect of targeted nursing intervention on negative mental status and quality of life of elderly patients with coronary heart disease.","authors":"Xiwei Chen, Ying Tian, Jing Qin, Jing Liu","doi":"10.23736/S0026-4806.20.06759-2","DOIUrl":"10.23736/S0026-4806.20.06759-2","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"690-692"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38074566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circular RNA circFANCL motivates the glioma progression via the action on the miR-337-3p/HMGB1 signal axis. 环状 RNA circFANCL 通过对 miR-337-3p/HMGB1 信号轴的作用推动胶质瘤的发展。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-12-01 Epub Date: 2020-07-17 DOI: 10.23736/S0026-4806.20.06639-2
Tao Wang, Jia Zhou, Mengshi Wu, Wei Luo, Feng Liang

Background: Circular RNAs (circRNAs) are significant modulatory molecules in the developing process of glioma. Our study will emphasize on exploring the function of circRNA Fanconi anemia group L protein (circFANCL) and the specific mechanism in glioma.

Methods: The quantitative real-time polymerase chain reaction (qRT-PCR) was implemented for detecting circFANCL, microRNA-337-3p (miR-337-3p) and high-mobility group box-1 (HMGB1). Cell proliferation analysis was assessed using cell counting kit-8 (CCK-8) and colony formation assays. Flow cytometry was applied to determine cell cycle and apoptosis. All protein detection was completed by western blot. Animal experiment was performed to investigate the role of circFANCL in vivo. Dual-luciferase reporter, RNA immunoprecipitation (RIP) and RNA pull-down assays were collectively conducted for analyzing the targeted combination.

Results: CircFANCL was signally increased in glioma tissues and cells, and the up-regulated circFANCL could predict poor prognosis in clinical glioma patients. Down-regulated circFANCL induced the proliferation inhibition, cell cycle arrest and apoptosis promotion of glioma cells in vitro, and inhibited tumor growth in vivo. Regarding the mechanism, circFANCL served as a sponge of miR-337-3p that was a tumor suppressor in glioma and circFANCL targeted miR-337-3p to regulate HMGB1 that was a target gene of miR-337-3p. Furthermore, HMGB1 down-regulation was responsible for the repression of glioma progression caused by knockdown of circFANCL.

Conclusions: Through the illustration of oncogenic function of circFANCL in glioma by the miR-337-3p/HMGB1 axis, we believed that circFANCL might be a great target in the early diagnosis and late treatment of glioma.

背景：环状RNA（circRNA）是胶质瘤发展过程中的重要调节分子。我们的研究将重点探讨循环RNA范可尼贫血L组蛋白（circFANCL）在胶质瘤中的功能及其具体机制：方法：采用实时定量聚合酶链反应（qRT-PCR）检测circFANCL、microRNA-337-3p（miR-337-3p）和高迁移率基团框-1（HMGB1）。细胞增殖分析采用细胞计数试剂盒-8（CCK-8）和集落形成试验进行评估。流式细胞术用于确定细胞周期和细胞凋亡。所有蛋白质检测均通过 Western 印迹法完成。为研究 circFANCL 在体内的作用，进行了动物实验。双荧光素酶报告、RNA免疫沉淀（RIP）和RNA下拉实验共同分析了靶向组合：结果：circFANCL在胶质瘤组织和细胞中明显增高，上调的circFANCL可预测临床胶质瘤患者的不良预后。下调的circFANCL在体外诱导胶质瘤细胞增殖抑制、细胞周期停滞和凋亡，在体内抑制肿瘤生长。在机制方面，circFANCL是胶质瘤抑癌基因miR-337-3p的海绵，circFANCL靶向miR-337-3p调控miR-337-3p的靶基因HMGB1。此外，HMGB1的下调是敲除circFANCL抑制胶质瘤进展的原因：通过miR-337-3p/HMGB1轴对circFANCL在胶质瘤中致癌功能的说明，我们认为circFANCL可能是胶质瘤早期诊断和晚期治疗的一个重要靶点。
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引用次数: 0
Reference value of magnetic resonance imaging and echocardiography in the diagnosis of pulmonary hypertension at high altitude. 磁共振成像和超声心动图在高海拔地区肺动脉高压诊断中的参考价值。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-12-01 Epub Date: 2020-07-21 DOI: 10.23736/S0026-4806.20.06760-9
Caiying Pei, Qianqian Cui, Qinghua Zhao, Yilin Liu, Chunxia Wang, Lihua Jing
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引用次数: 0
Platelet prothrombotic activity in COVID-19 survivors with persisting respiratory symptoms after 2 years from hospital discharge. COVID-19 存活者出院 2 年后仍有呼吸道症状的血小板促血栓形成活性。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-12-01 Epub Date: 2023-05-19 DOI: 10.23736/S0026-4806.23.08661-5
Filippo Consolo, Marilena Marmiere, Giuseppe A Ramirez, Alessandro Marinosci, Moreno Tresoldi, Giovanni Landoni, Alberto Zangrillo
{"title":"Platelet prothrombotic activity in COVID-19 survivors with persisting respiratory symptoms after 2 years from hospital discharge.","authors":"Filippo Consolo, Marilena Marmiere, Giuseppe A Ramirez, Alessandro Marinosci, Moreno Tresoldi, Giovanni Landoni, Alberto Zangrillo","doi":"10.23736/S0026-4806.23.08661-5","DOIUrl":"10.23736/S0026-4806.23.08661-5","url":null,"abstract":"","PeriodicalId":18671,"journal":{"name":"Minerva medica","volume":" ","pages":"695-697"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9480690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the effect of improved emergency nursing process on the treatment of patients with acute chest pain. 分析改进急诊护理流程对急性胸痛患者治疗的影响。
IF 4.7 4区 医学 0 MEDICINE, GENERAL & INTERNAL
Minerva medica
Pub Date : 2024-12-01 Epub Date: 2020-06-22 DOI: 10.23736/S0026-4806.20.06755-5
Jing Song, Jun Li, Xingzhen Wang, Li Liu
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引用次数: 0
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