Eating behavior disinhibition predicts insulin resistance in the Old Order Amish.

Journal of human nutrition and food science Pub Date : 2017-01-01 Epub Date: 2017-06-30

Sara Schwab, Timothy Xu, Kathleen Ryan, Nanette Steinle

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Abstract

Background: Eating behavior is influenced by genetics and environment, and is associated with many obesity related conditions.

Objective: We assessed the relationship between self-reported disinhibition scores and insulin resistance assessed during an oral glucose tolerance test (OGTT).

Design: The study included 779 volunteers from the Amish Family Diabetes Study; 77 with Type 2 Diabetes Mellitus, 133 with Impaired Glucose Tolerance (IGT) and 569 with Normal Glucose Tolerance (NGT). All patients with IGT and NGT completed oral glucose tolerance tests (OGTT), and had insulin levels measured during the OGTT. Volunteers completed the Three-Factor Eating Questionnaire to quantify self-perceived disinhibition.

Conclusions: Higher disinhibition scores are associated with higher fasting insulin levels and insulin area under the curve during an OGTT. These results suggest a highly significant, positive correlation between the eating behavior disinhibition and insulin insensitivity. Treatments aimed at modifying eating behavior may be helpful in mitigating insulin resistance.

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饮食行为去抑制预示着旧秩序阿米什人的胰岛素抵抗。

背景:饮食行为受遗传和环境的影响，并与许多肥胖相关疾病有关。目的:评估口服葡萄糖耐量试验(OGTT)中自我报告的去抑制评分与胰岛素抵抗之间的关系。设计:该研究包括来自阿米什家庭糖尿病研究的779名志愿者;2型糖尿病77例，糖耐量受损133例，糖耐量正常569例。所有IGT和NGT患者都完成了口服葡萄糖耐量试验(OGTT)，并在OGTT期间测量胰岛素水平。志愿者完成了三因素进食问卷来量化自我感知的解除抑制。结论:在OGTT期间，较高的去抑制评分与较高的空腹胰岛素水平和胰岛素曲线下面积相关。这些结果表明，饮食行为去抑制与胰岛素不敏感之间存在高度显著的正相关。旨在改变饮食行为的治疗可能有助于减轻胰岛素抵抗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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