The Effects of Ischemia and Hyperoxygenation on Hair Growth and Cycle.

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Organogenesis Pub Date : 2020-07-02 Epub Date: 2020-07-30 DOI:10.1080/15476278.2020.1794271

Harunosuke Kato, Kahori Kinoshita, Natsumi Saito, Koji Kanayama, Masanori Mori, Natsumi Asahi, Ataru Sunaga, Katsutoshi Yoshizato, Satoshi Itami, Kotaro Yoshimura

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引用次数: 8

Abstract

Alopecia has several causes, but its relationship with ischemia/hypoxia has not yet been investigated in detail. In this study, we studied the changes of hair follicles induced by ischemia and potential effects of normobaric hyperoxygenation (NBO) on the hair cycle and growth. We found that skin ischemia reduced hair growth rate, hair shaft size, and its pigmentation in the anagen phase of mice, which may reflect an aspect of pathophysiology of hair loss (alopecia) and depigmentation (gray/white hairs). Hyperoxygenation increased hair growth rate in organ culture of both human and murine hair follicles. Systemic NBO promoted hair growth in early anagen and mid-anagen, and delayed catagen onset in mice. However, telogen-to-anagen transition was not affected by NBO as far as non-ischemic skin is concerned. The results of this study indicated that the hair follicle is very sensitive to oxygen tension and oxygen tension affects the regulation of hair growth and cycle in vitro and in vivo. It was suggested that systemic NBO can be safely applied for a long period and can be a noninvasive therapeutic approach to alter hair growth and cycle by manipulating the microenvironment of hair follicles.

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缺血和高氧对头发生长和周期的影响。

脱发有多种原因，但其与缺血/缺氧的关系尚未详细研究。在本研究中，我们研究了缺血诱导毛囊的变化以及正压高氧(NBO)对头发周期和生长的潜在影响。我们发现，皮肤缺血降低了毛发生长速率、毛干大小及其在毛发生长初期的色素沉着，这可能反映了脱发(脱发)和色素沉着(白发)的病理生理方面。在人体和小鼠毛囊器官培养中，高氧可提高毛发生长速率。全身NBO可促进小鼠毛发生长早期和中期的生长，并可延缓毛发生长的发生。然而，就非缺血性皮肤而言，NBO不影响休止期到生长期的过渡。本研究结果表明，毛囊对氧张力非常敏感，氧张力在体外和体内影响毛发生长和周期的调节。结果表明，系统NBO可以长期安全应用，并且可以通过控制毛囊微环境来改变头发生长和周期，是一种无创治疗方法。

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.