Estrogen effects on orthodontic tooth movement and orthodontically-induced root resorption

IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Archives of oral biology Pub Date : 2020-10-01 DOI:10.1016/j.archoralbio.2020.104840
Lanzhi Deng , Yongwen Guo
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引用次数: 6

Abstract

Estrogen is an essential regulator of the bone tissue. The remodeling of the alveolar bone and periodontal ligament is the basis of orthodontic tooth movement (OTM). There is a negative coregulation between physiological estrogen levels and the rate of OTM. As a possible inhibitory factor of OTM, estrogen suppresses bone resorption by inhibiting osteoclastic differentiation and restraining osteoclast lifespan though multiple pathways and cytokines, leading to the suppression of the initiation step of bone remodeling. On the other hand, estrogen stimulates osteoblastic differentiation and function. Estrogen receptor-α (ERα) involves in the osteogenic responses to mechanical stimulation, and the ERα expression is regulated positively by the levels of circulatory estrogen. Orthodontically induced root resorption (OIRR) is a common side-effect of orthodontic treatment. Estrogen may have some inhibitory effects on OIRR, but more studies are needed to get an effective conclusion.

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雌激素对正畸牙齿运动和正畸诱导牙根吸收的影响
雌激素是骨组织的重要调节剂。牙槽骨和牙周韧带的重塑是正畸牙齿运动的基础。生理雌激素水平与OTM率呈负相关。雌激素作为OTM可能的抑制因子,通过多种途径和细胞因子抑制破骨细胞分化和抑制破骨细胞寿命,从而抑制骨吸收,从而抑制骨重塑的起始步骤。另一方面,雌激素刺激成骨细胞分化和功能。雌激素受体α (Estrogen receptor-α, ERα)参与机械刺激下的成骨反应,其表达受循环雌激素水平的正向调节。正畸诱导牙根吸收(OIRR)是正畸治疗中常见的副作用。雌激素可能对OIRR有一定的抑制作用,但需要更多的研究才能得出有效的结论。
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来源期刊
Archives of oral biology
Archives of oral biology 医学-牙科与口腔外科
CiteScore
5.10
自引率
3.30%
发文量
177
审稿时长
26 days
期刊介绍: Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry
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