首页 > 最新文献

Archives of oral biology最新文献

英文 中文
Colorimetric and visual assessment of two-color chewing gum mixing ability test: Correlation and reference parameters in dentate subjects
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-27 DOI: 10.1016/j.archoralbio.2025.106245
Murali Srinivasan , Lisa Takeshita , Prachi Jain , Yasmin Milhomens Moreira , Martin Schimmel , Claudio R. Leles

Objective

This study assessed the chewing performance of dentate subjects, using mixing ability tests with two-colored chewing gums, and aimed to correlate the visual and optoelectronic measurement methods to provide a correspondence scale for predicting the standard deviation of hue (SD-Hue) values based on visual parameters and the number of chewing strokes.

Design

Two chewing gums were used (Hue-Check Gum® and Vivident Fruitswing®), and tests were performed with 1, 5, 10, 15, 20, 25, and 30 chewing cycles. The analysis included optoelectronic analysis to measure the level of color mixture (ViewGum software) expressed as the SD-Hue, ranging from 0 to 1, where lower values correspond to a higher level of mixture, and subjective analysis (SA) on a 5-point ordinal scale. Data analysis included bivariate correlation, definition of double-sided 90 % reference ranges, and GEE regression.

Results

There were significant correlations between SD-Hue and the number of chewing cycles and SA scores (p < 0.001), and SA score was strongly correlated with the number of chewing cycles (p < 0.001). A downward logarithmic curve for SD-Hue and SA can be observed according to the number of chewing cycles. The mixture level progressively increased by approximately 50 % for each five chewing cycles.

Conclusion

It was possible to correlate visual and optoelectronic methods and to establish a scale prediction of SD-Hue values based on SA and the number of chewing cycles. The color mixing measured by optoelectronic and visual methods was proportional to the number of chewing cycles. For every five cycles, the level of color mixture was reduced by 50 %, expressed in a downward logarithmic curve, independently from the chewing gum type.
{"title":"Colorimetric and visual assessment of two-color chewing gum mixing ability test: Correlation and reference parameters in dentate subjects","authors":"Murali Srinivasan ,&nbsp;Lisa Takeshita ,&nbsp;Prachi Jain ,&nbsp;Yasmin Milhomens Moreira ,&nbsp;Martin Schimmel ,&nbsp;Claudio R. Leles","doi":"10.1016/j.archoralbio.2025.106245","DOIUrl":"10.1016/j.archoralbio.2025.106245","url":null,"abstract":"<div><h3>Objective</h3><div>This study assessed the chewing performance of dentate subjects, using mixing ability tests with two-colored chewing gums, and aimed to correlate the visual and optoelectronic measurement methods to provide a correspondence scale for predicting the standard deviation of hue (SD-Hue) values based on visual parameters and the number of chewing strokes.</div></div><div><h3>Design</h3><div>Two chewing gums were used (Hue-Check Gum® and Vivident Fruitswing®), and tests were performed with 1, 5, 10, 15, 20, 25, and 30 chewing cycles. The analysis included optoelectronic analysis to measure the level of color mixture (ViewGum software) expressed as the SD-Hue, ranging from 0 to 1, where lower values correspond to a higher level of mixture, and subjective analysis (SA) on a 5-point ordinal scale. Data analysis included bivariate correlation, definition of double-sided 90 % reference ranges, and GEE regression.</div></div><div><h3>Results</h3><div>There were significant correlations between SD-Hue and the number of chewing cycles and SA scores (p &lt; 0.001), and SA score was strongly correlated with the number of chewing cycles (p &lt; 0.001). A downward logarithmic curve for SD-Hue and SA can be observed according to the number of chewing cycles. The mixture level progressively increased by approximately 50 % for each five chewing cycles.</div></div><div><h3>Conclusion</h3><div>It was possible to correlate visual and optoelectronic methods and to establish a scale prediction of SD-Hue values based on SA and the number of chewing cycles. The color mixing measured by optoelectronic and visual methods was proportional to the number of chewing cycles. For every five cycles, the level of color mixture was reduced by 50 %, expressed in a downward logarithmic curve, independently from the chewing gum type.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106245"},"PeriodicalIF":2.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the effect of platelet-derived growth factor-BB on the biological activity of human mandibular bone marrow-derived mesenchymal stem cells
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-26 DOI: 10.1016/j.archoralbio.2025.106244
Yurika Oura, Masakazu Ishii, Haruka Miyata, Nao Ikeda, Tomoaki Sakurai, Fumio Suehiro, Naohiro Komabashiri, Masahiro Nishimura

Objective

This study aimed to investigate the effects of platelet-derived growth factor-BB (PDGF-BB) on the biological activities of human mandibular bone marrow-derived mesenchymal stem cells (MBMSCs).

Design

PDGF-BB (20 ng/mL) was used to treat MBMSCs, and its effects on their proliferation, osteogenic differentiation, and migration were evaluated. Cell proliferation was evaluated using a WST-1 assay. Osteogenic differentiation was evaluated by measuring the mineralization potential and alkaline phosphatase activity. Cell migration was evaluated using wound healing and Transwell chamber assays. Cytoskeletal reorganization and adhesion dynamics were evaluated using immunofluorescence staining. Changes in intracellular signaling in MBMSCs induced by PDGF-BB stimulation were evaluated using western blotting. Furthermore, we investigated Girdin signaling as the molecular mechanisms underlying the regulation of PDGF-BB-induced cell migration.

Results

PDGF-BB treatment did not affect the proliferation or osteogenic differentiation of MBMSCs. PDGF-BB promoted the migration of MBMSCs. PDGF-BB treatment enhanced F-actin filament formation and paxillin localization at the leading edge of cells. PDGF-BB treatment activated Akt signaling in MBMSCs, and the inhibition of Akt signaling effectively suppressed PDGF-BB-induced Akt activation and migration. PDGF-BB promoted the phosphorylation of Girdin in MBMSCs, and the inhibition of Akt signaling attenuated PDGF-BB-induced Girdin activation.

Conclusion

This study demonstrated that PDGF-BB strongly induces the migration of MBMSCs without affecting their proliferation or osteogenic differentiation. Furthermore, PDGF-BB-induced migration of MBMSCs may be mediated through the Akt/Girdin signaling pathway. These findings provide important insight into the molecular mechanisms underlying PDGF-BB-induced periodontal tissue regeneration.
目的 本研究旨在探讨血小板衍生生长因子-BB(PDGF-BB)对人下颌骨骨髓间充质干细胞(MBMSCs)生物活性的影响。设计用血小板衍生生长因子-BB(20 ng/mL)处理MBMSCs,并评估其对细胞增殖、成骨分化和迁移的影响。细胞增殖采用 WST-1 试验进行评估。成骨分化通过测量矿化电位和碱性磷酸酶活性进行评估。细胞迁移是通过伤口愈合和 Transwell 室试验进行评估的。使用免疫荧光染色法评估细胞骨架重组和粘附动态。使用 Western 印迹法评估了 PDGF-BB 刺激诱导的 MBMSCs 细胞内信号的变化。此外,我们还研究了调节 PDGF-BB 诱导的细胞迁移的分子机制--Girdin 信号转导。PDGF-BB促进了MBMSCs的迁移。PDGF-BB处理增强了F-肌动蛋白丝的形成和paxillin在细胞前缘的定位。PDGF-BB 可激活 MBMSCs 中的 Akt 信号转导,抑制 Akt 信号转导可有效抑制 PDGF-BB 诱导的 Akt 激活和迁移。PDGF-BB 促进了 MBMSCs 中 Girdin 的磷酸化,抑制 Akt 信号转导可减轻 PDGF-BB 诱导的 Girdin 激活。此外,PDGF-BB 诱导的 MBMSCs 迁移可能是通过 Akt/Girdin 信号通路介导的。这些发现为我们深入了解 PDGF-BB 诱导牙周组织再生的分子机制提供了重要依据。
{"title":"Evaluation of the effect of platelet-derived growth factor-BB on the biological activity of human mandibular bone marrow-derived mesenchymal stem cells","authors":"Yurika Oura,&nbsp;Masakazu Ishii,&nbsp;Haruka Miyata,&nbsp;Nao Ikeda,&nbsp;Tomoaki Sakurai,&nbsp;Fumio Suehiro,&nbsp;Naohiro Komabashiri,&nbsp;Masahiro Nishimura","doi":"10.1016/j.archoralbio.2025.106244","DOIUrl":"10.1016/j.archoralbio.2025.106244","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of platelet-derived growth factor-BB (PDGF-BB) on the biological activities of human mandibular bone marrow-derived mesenchymal stem cells (MBMSCs).</div></div><div><h3>Design</h3><div>PDGF-BB (20 ng/mL) was used to treat MBMSCs, and its effects on their proliferation, osteogenic differentiation, and migration were evaluated. Cell proliferation was evaluated using a WST-1 assay. Osteogenic differentiation was evaluated by measuring the mineralization potential and alkaline phosphatase activity. Cell migration was evaluated using wound healing and Transwell chamber assays. Cytoskeletal reorganization and adhesion dynamics were evaluated using immunofluorescence staining. Changes in intracellular signaling in MBMSCs induced by PDGF-BB stimulation were evaluated using western blotting. Furthermore, we investigated Girdin signaling as the molecular mechanisms underlying the regulation of PDGF-BB-induced cell migration.</div></div><div><h3>Results</h3><div>PDGF-BB treatment did not affect the proliferation or osteogenic differentiation of MBMSCs. PDGF-BB promoted the migration of MBMSCs. PDGF-BB treatment enhanced F-actin filament formation and paxillin localization at the leading edge of cells. PDGF-BB treatment activated Akt signaling in MBMSCs, and the inhibition of Akt signaling effectively suppressed PDGF-BB-induced Akt activation and migration. PDGF-BB promoted the phosphorylation of Girdin in MBMSCs, and the inhibition of Akt signaling attenuated PDGF-BB-induced Girdin activation.</div></div><div><h3>Conclusion</h3><div>This study demonstrated that PDGF-BB strongly induces the migration of MBMSCs without affecting their proliferation or osteogenic differentiation. Furthermore, PDGF-BB-induced migration of MBMSCs may be mediated through the Akt/Girdin signaling pathway. These findings provide important insight into the molecular mechanisms underlying PDGF-BB-induced periodontal tissue regeneration.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106244"},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macronutrient consumption in adults and association with oral and systemic parameters: A cross-sectional study
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-23 DOI: 10.1016/j.archoralbio.2025.106241
Larisse Santos Mendonça Alves , Júlia Maria Munduri , Israel Lacerda , Letícia Gonçalves Reis , Joana Rodrigues da Silva , Cristine Miron Stefani , Maria do Carmo Machado Guimarães , Luana Severo Alves , Solange Baraldi , Naile Dame-Teixeira

Objective

Oral conditions, such as tooth loss and changes in taste perception, can affect the consumption of dietary macronutrients. Our aim was to study systemic and oral alterations associated with inadequate consumption of macronutrients in adults and elderly with and without type 2 diabetes mellitus (T2D).

Design

This cross-sectional study included 170 individuals. Sociodemographic variables and clinical parameters were collected, such as weight status, waist circumference risk, T2D, smoking history, presence of removable dentures, worsening taste, among others. Outcomes included intakes of carbohydrates, lipids, fibers, and proteins. Poisson regression models were used to estimate prevalence ratios (PR) and 95 % confidence intervals (CI).

Results

Individuals reporting a worsening in taste perception were nearly four times more likely to have a high carbohydrate intake (PR=3.84; 95 % CI: 1.36–10.83). Saliva flow rate was significantly associated with increased lipid intake (PR=0.21; 95 % CI: 0.05–0.89). The presence of removable dentures in both arches (PR=1.40; 95 % CI: 1.07–1.81) and high cardiovascular risk (based on waist circumference) (PR=1.86; 95 % CI: 1.06–3.26) were associated with a higher prevalence of low fiber intake. These associations with fiber were influenced by saliva flow rate. Individuals aged ≥ 60 years (PR=1.12; 95 % CI: 1.00–1.24), using removable dentures in one arch (PR=1.23; 95 % CI: 1.04–1.46) or both arches (PR=1.22; 95 % CI: 1.04–1.45) had a higher prevalence of inadequate protein intake.

Conclusions

Demographic factors, systemic and oral conditions were significantly associated with inadequate macronutrient intake, highlighting the essential contribution of dentistry to addressing broader systemic health issues.
{"title":"Macronutrient consumption in adults and association with oral and systemic parameters: A cross-sectional study","authors":"Larisse Santos Mendonça Alves ,&nbsp;Júlia Maria Munduri ,&nbsp;Israel Lacerda ,&nbsp;Letícia Gonçalves Reis ,&nbsp;Joana Rodrigues da Silva ,&nbsp;Cristine Miron Stefani ,&nbsp;Maria do Carmo Machado Guimarães ,&nbsp;Luana Severo Alves ,&nbsp;Solange Baraldi ,&nbsp;Naile Dame-Teixeira","doi":"10.1016/j.archoralbio.2025.106241","DOIUrl":"10.1016/j.archoralbio.2025.106241","url":null,"abstract":"<div><h3>Objective</h3><div>Oral conditions, such as tooth loss and changes in taste perception, can affect the consumption of dietary macronutrients. Our aim was to study systemic and oral alterations associated with inadequate consumption of macronutrients in adults and elderly with and without type 2 diabetes mellitus (T2D).</div></div><div><h3>Design</h3><div>This cross-sectional study included 170 individuals. Sociodemographic variables and clinical parameters were collected, such as weight status, waist circumference risk, T2D, smoking history, presence of removable dentures, worsening taste, among others. Outcomes included intakes of carbohydrates, lipids, fibers, and proteins. Poisson regression models were used to estimate prevalence ratios (PR) and 95 % confidence intervals (CI).</div></div><div><h3>Results</h3><div>Individuals reporting a worsening in taste perception were nearly four times more likely to have a high carbohydrate intake (PR=3.84; 95 % CI: 1.36–10.83). Saliva flow rate was significantly associated with increased lipid intake (PR=0.21; 95 % CI: 0.05–0.89). The presence of removable dentures in both arches (PR=1.40; 95 % CI: 1.07–1.81) and high cardiovascular risk (based on waist circumference) (PR=1.86; 95 % CI: 1.06–3.26) were associated with a higher prevalence of low fiber intake. These associations with fiber were influenced by saliva flow rate. Individuals aged ≥ 60 years (PR=1.12; 95 % CI: 1.00–1.24), using removable dentures in one arch (PR=1.23; 95 % CI: 1.04–1.46) or both arches (PR=1.22; 95 % CI: 1.04–1.45) had a higher prevalence of inadequate protein intake.</div></div><div><h3>Conclusions</h3><div>Demographic factors, systemic and oral conditions were significantly associated with inadequate macronutrient intake, highlighting the essential contribution of dentistry to addressing broader systemic health issues.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106241"},"PeriodicalIF":2.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Senescent vascular endothelial cells promote oral squamous cell carcinoma progression through complement C3 activation
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-23 DOI: 10.1016/j.archoralbio.2025.106242
Fangqi Jing , Jingtian Mu , Junjiang Liu , Can Hu , Fanglong Wu , Qinghong Gao

Objective

The tumour microenvironment (TME) plays a critical role in therapeutic response and clinical outcomes in cancer. Senescent stromal cells have been shown to promote tumour progression; however, the role of senescent vascular endothelial cells (VECs) in oral squamous cell carcinoma (OSCC) remains largely unknown. In this study, we aimed to explore the effects and potential mechanisms of senescent VECs in OSCC progression.

Design

Cisplatin was used to induce senescence in two endothelial cell lines. Senescence-associated β-galactosidase (SA-β-gal) staining, immunoblotting, cell cycle and proliferation assays, and migration and invasion assays were performed to access senescence development and biological behavior. Additionally, RNA sequencing analysis, multiplex immunohistochemical staining, immunoblotting, and xenograft mouse models were used to investigate the senescence-associated secretory phenotype of senescent VECs during OSCC progression and its potential molecular mechanisms.

Results

Cisplatin-induced senescent VECs exhibited senescence-related changes, including positive SA-β-gal expression and upregulation of p16, p21, and p53, along with attenuated proliferation and migration. Notably, cisplatin-induced VEC senescence promoted OSCC cell proliferation, migration, and invasion by activating complement C3. Increased gene and protein levels of C3 were observed in cisplatin-treated senescent VECs. Inhibition of C3 in vitro and in vivo reduced OSCC cell proliferation and invasion.

Conclusion

Senescent VECs induced by cisplatin promote OSCC proliferation and invasion through complement C3 activation. Targeting complement C3 in senescent VECs may offer a novel therapeutic strategy for OSCC treatment.
{"title":"Senescent vascular endothelial cells promote oral squamous cell carcinoma progression through complement C3 activation","authors":"Fangqi Jing ,&nbsp;Jingtian Mu ,&nbsp;Junjiang Liu ,&nbsp;Can Hu ,&nbsp;Fanglong Wu ,&nbsp;Qinghong Gao","doi":"10.1016/j.archoralbio.2025.106242","DOIUrl":"10.1016/j.archoralbio.2025.106242","url":null,"abstract":"<div><h3>Objective</h3><div>The tumour microenvironment (TME) plays a critical role in therapeutic response and clinical outcomes in cancer. Senescent stromal cells have been shown to promote tumour progression; however, the role of senescent vascular endothelial cells (VECs) in oral squamous cell carcinoma (OSCC) remains largely unknown. In this study, we aimed to explore the effects and potential mechanisms of senescent VECs in OSCC progression.</div></div><div><h3>Design</h3><div>Cisplatin was used to induce senescence in two endothelial cell lines. Senescence-associated β-galactosidase (SA-β-gal) staining, immunoblotting, cell cycle and proliferation assays, and migration and invasion assays were performed to access senescence development and biological behavior. Additionally, RNA sequencing analysis, multiplex immunohistochemical staining, immunoblotting, and xenograft mouse models were used to investigate the senescence-associated secretory phenotype of senescent VECs during OSCC progression and its potential molecular mechanisms.</div></div><div><h3>Results</h3><div>Cisplatin-induced senescent VECs exhibited senescence-related changes, including positive SA-β-gal expression and upregulation of p16, p21, and p53, along with attenuated proliferation and migration. Notably, cisplatin-induced VEC senescence promoted OSCC cell proliferation, migration, and invasion by activating complement C3. Increased gene and protein levels of C3 were observed in cisplatin-treated senescent VECs. Inhibition of C3 in vitro and in vivo reduced OSCC cell proliferation and invasion.</div></div><div><h3>Conclusion</h3><div>Senescent VECs induced by cisplatin promote OSCC proliferation and invasion through complement C3 activation. Targeting complement C3 in senescent VECs may offer a novel therapeutic strategy for OSCC treatment.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106242"},"PeriodicalIF":2.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Akkermansia muciniphila enhances mucosal immunity against porphyromonas gingivalis
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-23 DOI: 10.1016/j.archoralbio.2025.106240
Qin Hu , Wai Keung Leung , Aneesha Acharya , George Pelekos

Objective

This study aims to investigate the immunomodulatory potential of Akkermansia muciniphila in restoring Porphyromonas gingivalis-induced immune dysfunction.

Design

The immune response was assessed by measuring the expression of pro-inflammatory cytokines and antibacterial peptides in human gingival epithelial cells and human gingival fibroblasts treated with A. muciniphila, P. gingivalis, or a combination of both. Activation of the NF-κB pathway was analyzed using immunofluorescent staining and western blot. In vivo validation was performed using a mouse model, where A. muciniphila and P. gingivalis were administered alongside a MyD88-specific inhibitor to confirm the immunomodulatory mechanisms.

Results

A. muciniphila significantly enhanced the defensive immune response through TLR-MYD88-NF-κB pathway. In vitro and in vivo, A. muciniphila upregulated chemokine expression to recruit immune cells. A. muciniphila also reduced the adhesion and internalization of P. gingivalis and increased the expression of genes encoding antimicrobial peptides (DEFB103B and CAMP).

Conclusions

A. muciniphila demonstrates potential in combating P. gingivalis infection highlighting its role as a promising immune modulator for periodontal disease management.
{"title":"Akkermansia muciniphila enhances mucosal immunity against porphyromonas gingivalis","authors":"Qin Hu ,&nbsp;Wai Keung Leung ,&nbsp;Aneesha Acharya ,&nbsp;George Pelekos","doi":"10.1016/j.archoralbio.2025.106240","DOIUrl":"10.1016/j.archoralbio.2025.106240","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate the immunomodulatory potential of <em>Akkermansia muciniphila</em> in restoring <em>Porphyromonas gingivalis</em>-induced immune dysfunction.</div></div><div><h3>Design</h3><div>The immune response was assessed by measuring the expression of pro-inflammatory cytokines and antibacterial peptides in human gingival epithelial cells and human gingival fibroblasts treated with <em>A. muciniphila, P. gingivalis</em>, or a combination of both. Activation of the NF-κB pathway was analyzed using immunofluorescent staining and western blot. <em>In vivo</em> validation was performed using a mouse model, where <em>A. muciniphila</em> and <em>P. gingivalis</em> were administered alongside a MyD88-specific inhibitor to confirm the immunomodulatory mechanisms.</div></div><div><h3>Results</h3><div><em>A. muciniphila</em> significantly enhanced the defensive immune response through TLR-MYD88-NF-κB pathway. <em>In vitro</em> and <em>in vivo</em>, <em>A. muciniphila</em> upregulated chemokine expression to recruit immune cells. <em>A. muciniphila</em> also reduced the adhesion and internalization of <em>P. gingivalis</em> and increased the expression of genes encoding antimicrobial peptides (<em>DEFB103B</em> and <em>CAMP</em>).</div></div><div><h3>Conclusions</h3><div><em>A. muciniphila</em> demonstrates potential in combating <em>P. gingivalis</em> infection highlighting its role as a promising immune modulator for periodontal disease management.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106240"},"PeriodicalIF":2.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High prevalence of oral cavity parasites and its related risk factors in Iranian children with stomatitis; A case-control study
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-21 DOI: 10.1016/j.archoralbio.2025.106239
Behnoush Selahbarzin , Yosra Raziani , Azadeh Jafrasteh , Parastoo Baharvand , Fatemeh Doulatshah , Hossein Mahmoudvand , Fahimeh Kooshki

Objective

This study for the first time seeks to assess the prevalence, socio-economic characteristics, and risk factors associated with oral cavity parasites (Entamoeba gingivalis (Eg) and Trichomonas tenax (Tt)) in children with stomatitis in Lorestan province, Western Iran.

Design

The present case-control study encompassed a group of 215 children with stomatitis (ST) and 215 children without stomatitis (non-ST) who were referred to healthcare facilities in Lorestan province, Iran, between December 2024 and January 2025. Samples were collected from participants and were analyzed under a light microscope.

Results

The overall prevalence of oral parasites in children with ST was determined to be 59 (27.4 %) and 64 (29.8 %) using microscopic examination and PCR techniques, respectively. Among the positive cases, 48 (75.0 %) of the children were found to be positive for Eg, while 16 (25.0 %) tested positive for Tt. The likelihood of encountering oral cavity parasites among ST participants is markedly higher compared to that of the non-ST group (p < 0.001, OR=2.180; CI= 1.369–3.471). In the multivariate analysis, several factors were found to be significantly associated with parasitic infection, including male gender (p = 0.024, OR= 2.173, 95 % CI: 1.107–4.265), high parental education (p = 0.007, OR= 3.138, 95 % CI:1.373–7.170), living in urban regions (p = 0.000, OR=0.259, 95 % CI: 0.123–0.546), and the use of mouthwash (p = 0.000).

Conclusion

The research revealed a significant occurrence of oral cavity parasites among children with stomatitis in Lorestan province, Western Iran. Consequently, pediatric dental practitioners should maintain a heightened awareness of these risk factors for reducing the prevalence of oral infections in children.
{"title":"High prevalence of oral cavity parasites and its related risk factors in Iranian children with stomatitis; A case-control study","authors":"Behnoush Selahbarzin ,&nbsp;Yosra Raziani ,&nbsp;Azadeh Jafrasteh ,&nbsp;Parastoo Baharvand ,&nbsp;Fatemeh Doulatshah ,&nbsp;Hossein Mahmoudvand ,&nbsp;Fahimeh Kooshki","doi":"10.1016/j.archoralbio.2025.106239","DOIUrl":"10.1016/j.archoralbio.2025.106239","url":null,"abstract":"<div><h3>Objective</h3><div>This study for the first time seeks to assess the prevalence, socio-economic characteristics, and risk factors associated with oral cavity parasites (<em>Entamoeba gingivalis</em> (Eg) and <em>Trichomonas tenax</em> (Tt)) in children with stomatitis in Lorestan province, Western Iran.</div></div><div><h3>Design</h3><div>The present case-control study encompassed a group of 215 children with stomatitis (ST) and 215 children without stomatitis (non-ST) who were referred to healthcare facilities in Lorestan province, Iran, between December 2024 and January 2025. Samples were collected from participants and were analyzed under a light microscope.</div></div><div><h3>Results</h3><div>The overall prevalence of oral parasites in children with ST was determined to be 59 (27.4 %) and 64 (29.8 %) using microscopic examination and PCR techniques, respectively. Among the positive cases, 48 (75.0 %) of the children were found to be positive for Eg, while 16 (25.0 %) tested positive for Tt. The likelihood of encountering oral cavity parasites among ST participants is markedly higher compared to that of the non-ST group (p &lt; 0.001, OR=2.180; CI= 1.369–3.471). In the multivariate analysis, several factors were found to be significantly associated with parasitic infection, including male gender (p = 0.024, OR= 2.173, 95 % CI: 1.107–4.265), high parental education (p = 0.007, OR= 3.138, 95 % CI:1.373–7.170), living in urban regions (p = 0.000, OR=0.259, 95 % CI: 0.123–0.546), and the use of mouthwash (p = 0.000).</div></div><div><h3>Conclusion</h3><div>The research revealed a significant occurrence of oral cavity parasites among children with stomatitis in Lorestan province, Western Iran. Consequently, pediatric dental practitioners should maintain a heightened awareness of these risk factors for reducing the prevalence of oral infections in children.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106239"},"PeriodicalIF":2.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gallic acid promotes M2 macrophage polarization through mitochondrial oxidative phosphorylation in periodontitis
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-15 DOI: 10.1016/j.archoralbio.2025.106237
Ruobing Zhang , Wenjing Yang , Kai Li , Xiaolong Zhang , Jie Liu , Lin Ai

Objective

This in vitro investigation assessed the role of gallic acid in regulating macrophage polarization.

Design

In this study, RAW264.7 macrophages were treated with P. gingivalis lipopolysaccharide (LPS) to mimic inflammatory conditions in periodontitis. Immunofluorescence staining, enzyme‑linked immunosorbent (ELISA) assay, RNA sequencing, and seahorse metabolic profile assay were used to assess the effects of gallic acid on macrophage polarization, cytokine release, underlying mechanism and metabolic profile.

Results

The study demonstrated that treatment with gallic acid could induce M2 polarization of macrophages (P < 0.01) and increase the production of anti-inflammatory cytokines (P < 0.01). Analysis of RNA sequencing data showed enrichment of mitochondrial oxidative phosphorylation, regulation of metabolic processes, and the PI3K-Akt signaling pathway in LPS-treated macrophages treated with gallic acid. Furthermore, gallic acid was found to enhance mitochondrial oxidative phosphorylation activity through the PI3K-Akt signaling pathway in RAW264.7 cells.

Conclusions

Gallic acid treatment has the potential to promote M2 polarization of macrophages by modulating mitochondrial oxidative phosphorylation via the PI3K-Akt signaling pathway.
{"title":"Gallic acid promotes M2 macrophage polarization through mitochondrial oxidative phosphorylation in periodontitis","authors":"Ruobing Zhang ,&nbsp;Wenjing Yang ,&nbsp;Kai Li ,&nbsp;Xiaolong Zhang ,&nbsp;Jie Liu ,&nbsp;Lin Ai","doi":"10.1016/j.archoralbio.2025.106237","DOIUrl":"10.1016/j.archoralbio.2025.106237","url":null,"abstract":"<div><h3>Objective</h3><div>This in vitro investigation assessed the role of gallic acid in regulating macrophage polarization.</div></div><div><h3>Design</h3><div>In this study, RAW264.7 macrophages were treated with <em>P. gingivalis</em> lipopolysaccharide (LPS) to mimic inflammatory conditions in periodontitis. Immunofluorescence staining, enzyme‑linked immunosorbent (ELISA) assay, RNA sequencing, and seahorse metabolic profile assay were used to assess the effects of gallic acid on macrophage polarization, cytokine release, underlying mechanism and metabolic profile.</div></div><div><h3>Results</h3><div>The study demonstrated that treatment with gallic acid could induce M2 polarization of macrophages (<em>P</em> &lt; 0.01) and increase the production of anti-inflammatory cytokines (<em>P</em> &lt; 0.01). Analysis of RNA sequencing data showed enrichment of mitochondrial oxidative phosphorylation, regulation of metabolic processes, and the PI3K-Akt signaling pathway in LPS-treated macrophages treated with gallic acid. Furthermore, gallic acid was found to enhance mitochondrial oxidative phosphorylation activity through the PI3K-Akt signaling pathway in RAW264.7 cells.</div></div><div><h3>Conclusions</h3><div>Gallic acid treatment has the potential to promote M2 polarization of macrophages by modulating mitochondrial oxidative phosphorylation via the PI3K-Akt signaling pathway.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106237"},"PeriodicalIF":2.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advance in candidate genes in mandibular retrognathism: A systematic review
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-13 DOI: 10.1016/j.archoralbio.2025.106234
Li Yang , Weiping Yang , Yining Shen , Yu Zhou

Objective

This research aims to dissect the polygenic nature of non-syndromic mandibular retrognathism (MR) and to better understand the genetic underpinnings of MR, with a particular focus on the role of ethnic diversity in influencing genetic predispositions.

Methods

A comprehensive systematic review was conducted on MR. Electronic databases such as PubMed and Google Scholar were employed, utilizing terms like 'mandibular', 'retrognathism', 'gene', and 'genetic'. This study strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework.

Results

Ten genetic studies were identified that satisfied the eligibility criteria, involving 1010 participants. Variations in candidate genes were reported across different populations, including myosin 1 H (MYO1H), matrilin 1 (MATN1), a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9), bone morphogenetic protein 2 (BMP2), parathyroid hormone (PTH), the vitamin-D related genes: vitamin D receptor (VDR), cytochrome P450 family 24 subfamily A member 1 (CYP24A1), and cytochrome P450 family 27 subfamily B member 1 (CYP27B1), collagen type II alpha 1 chain (COL2A1), transforming growth factor-β (TGF-β), TGF-β receptor 2 (TGFBR2), epidermal growth factor (EGF), and EGF receptor gene (EGFR).

Conclusion

These findings shed light on the role of genetic factors in MR. Future studies should adopt a multicentric approach to expand sample sizes and enhance the analysis of genetic variants associated with MR.
{"title":"Advance in candidate genes in mandibular retrognathism: A systematic review","authors":"Li Yang ,&nbsp;Weiping Yang ,&nbsp;Yining Shen ,&nbsp;Yu Zhou","doi":"10.1016/j.archoralbio.2025.106234","DOIUrl":"10.1016/j.archoralbio.2025.106234","url":null,"abstract":"<div><h3>Objective</h3><div>This research aims to dissect the polygenic nature of non-syndromic mandibular retrognathism (MR) and to better understand the genetic underpinnings of MR, with a particular focus on the role of ethnic diversity in influencing genetic predispositions.</div></div><div><h3>Methods</h3><div>A comprehensive systematic review was conducted on MR. Electronic databases such as PubMed and Google Scholar were employed, utilizing terms like 'mandibular', 'retrognathism', 'gene', and 'genetic'. This study strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework.</div></div><div><h3>Results</h3><div>Ten genetic studies were identified that satisfied the eligibility criteria, involving 1010 participants. Variations in candidate genes were reported across different populations, including myosin 1 H (<em>MYO1H</em>), matrilin 1 (<em>MATN1</em>), a disintegrin and metalloproteinase with thrombospondin motifs 9 (<em>ADAMTS9</em>), bone morphogenetic protein 2 (<em>BMP2</em>), parathyroid hormone (<em>PTH</em>), the vitamin-D related genes: vitamin D receptor (<em>VDR</em>), cytochrome P450 family 24 subfamily A member 1 (<em>CYP24A1</em>), and cytochrome P450 family 27 subfamily B member 1 (<em>CYP27B1</em>), collagen type II alpha 1 chain (<em>COL2A1</em>), transforming growth factor-β (<em>TGF-β</em>), <em>TGF</em>-β receptor 2 (<em>TGFBR2</em>), epidermal growth factor (<em>EGF</em>), and EGF receptor gene (<em>EGFR</em>).</div></div><div><h3>Conclusion</h3><div>These findings shed light on the role of genetic factors in MR. Future studies should adopt a multicentric approach to expand sample sizes and enhance the analysis of genetic variants associated with MR.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106234"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single monoiodoacetic acid injection reveals toll-like receptor, oestrogen, oxidative stress, and altered energy metabolism as key drivers of temporomandibular joint osteoarthritis in female rats
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-13 DOI: 10.1016/j.archoralbio.2025.106233
Shasha Liu , Chaolun Wu , Yuan Yao , Xiongwei Dong , Lili Xu

Objectives

This study aimed to establish a reproducible and minimally invasive rat model of temporomandibular joint osteoarthritis (TMJ-OA) using intra-articular monoiodoacetic acid (MIA) injection, and to investigate the pathological mechanisms underlying TMJ-OA development, aimed at providing insights for potential clinical treatments.

Design

We compared the effects of single versus multiple MIA injections on body weight, pain behaviour, and condylar pathology in female Sprague–Dawley rats. We longitudinally assessed the progression of TMJ-OA over 5 weeks by evaluating condylar pathology and immunohistochemical staining. We investigated the potential mechanism of MIA-induced TMJ-OA through transcriptome sequencing and polymerase chain reaction validation.

Results

A single MIA injection (0.5 mg) into the joint space effectively induced TMJ-OA in rats and sustained inflammatory reactions and pain without significantly affecting weight. MIA continuously promoted the development of TMJ-OA through the activation of the toll-like receptor pathway, oestrogen metabolism promotion, oxidative stress response enhancement, and energy metabolism alteration in condylar chondrocytes.

Conclusion

We have presented a simple and minimally invasive method for modelling TMJ-OA in rats, which can be utilised in animal trials focusing on TMJ-OA treatment strategies. The study also reveals toll-like receptor, oestrogen, oxidative stress, and altered energy metabolism as key drivers of TMJ-OA in female rats.
{"title":"Single monoiodoacetic acid injection reveals toll-like receptor, oestrogen, oxidative stress, and altered energy metabolism as key drivers of temporomandibular joint osteoarthritis in female rats","authors":"Shasha Liu ,&nbsp;Chaolun Wu ,&nbsp;Yuan Yao ,&nbsp;Xiongwei Dong ,&nbsp;Lili Xu","doi":"10.1016/j.archoralbio.2025.106233","DOIUrl":"10.1016/j.archoralbio.2025.106233","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to establish a reproducible and minimally invasive rat model of temporomandibular joint osteoarthritis (TMJ-OA) using intra-articular monoiodoacetic acid (MIA) injection, and to investigate the pathological mechanisms underlying TMJ-OA development, aimed at providing insights for potential clinical treatments.</div></div><div><h3>Design</h3><div>We compared the effects of single versus multiple MIA injections on body weight, pain behaviour, and condylar pathology in female Sprague–Dawley rats. We longitudinally assessed the progression of TMJ-OA over 5 weeks by evaluating condylar pathology and immunohistochemical staining. We investigated the potential mechanism of MIA-induced TMJ-OA through transcriptome sequencing and polymerase chain reaction validation.</div></div><div><h3>Results</h3><div>A single MIA injection (0.5 mg) into the joint space effectively induced TMJ-OA in rats and sustained inflammatory reactions and pain without significantly affecting weight. MIA continuously promoted the development of TMJ-OA through the activation of the toll-like receptor pathway, oestrogen metabolism promotion, oxidative stress response enhancement, and energy metabolism alteration in condylar chondrocytes.</div></div><div><h3>Conclusion</h3><div>We have presented a simple and minimally invasive method for modelling TMJ-OA in rats, which can be utilised in animal trials focusing on TMJ-OA treatment strategies. The study also reveals toll-like receptor, oestrogen, oxidative stress, and altered energy metabolism as key drivers of TMJ-OA in female rats.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106233"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of oral conditions to explore subsistence strategies in the ecologically diverse environments of the Canary Islands during the Amazigh period (1st to 15th centuries CE) 分析口腔状况,探索阿马齐格时期(公元 1 世纪至 15 世纪)加那利群岛生态多样化环境中的生存策略
IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-12 DOI: 10.1016/j.archoralbio.2025.106236
Aarón Morquecho Izquier , Rebeca García González , Elías Sánchez Cañadillas , Jonathan Santana
Objective:
This study examines oral health conditions in the pre-European Amazigh population of the Canary Islands (1st–15th centuries) to uncover patterns linked to island-specific environments and subsistence practices. The Canary Islands offered diverse ecological settings that shaped how the Amazigh adapted their agricultural practices, creating landscapes to support settlement.
Design:
By analyzing the oral health of 615 adult individuals across seven major islands—including caries, dental wear, calculus, periodontal disease, and antemortem tooth loss—the study identifies three distinct patterns of oral health within the archipelago.
Results:
Gran Canaria exhibited the highest prevalence of dental caries, aligning with an agriculture-centered lifestyle. In contrast, La Gomera, Fuerteventura, and Lanzarote showed the lowest caries rates, suggesting less agricultural dependence. El Hierro and La Palma populations presented both high caries prevalence and extensive dental wear, likely due to a diet including famine-related foods like fern roots. The findings also indicate sex-based differences in oral health across islands but no significant distinctions by age.
Conclusions:
These patterns highlight a relationship between the diverse biogeography of the islands, subsistence strategies, and oral health in the Amazigh period. This study contributes valuable insights into how different environments and resource availability impacted the diet and health of the Canary Islands’ Amazigh populations.
目的:本研究调查了加那利群岛(1 世纪至 15 世纪)欧洲前阿马齐格人的口腔健康状况,以揭示与岛屿特定环境和生存方式相关的模式。设计:通过分析七个主要岛屿上 615 名成年人的口腔健康状况(包括龋齿、牙齿磨损、牙结石、牙周病和死前牙齿脱落),该研究确定了群岛内三种不同的口腔健康模式。结果:大加那利岛的龋齿发病率最高,这与以农业为中心的生活方式相符。相比之下,拉戈梅拉、富埃特文图拉和兰扎罗特的龋齿率最低,表明对农业的依赖程度较低。埃尔希耶罗和拉帕尔马的龋齿发病率高,牙齿磨损严重,这很可能是由于他们的饮食中含有蕨根等与饥荒有关的食物。研究结果还表明,各岛屿的口腔健康状况存在性别差异,但年龄差异并不明显。这项研究有助于深入了解不同的环境和资源供应如何影响加那利群岛阿马齐格人的饮食和健康。
{"title":"Analysis of oral conditions to explore subsistence strategies in the ecologically diverse environments of the Canary Islands during the Amazigh period (1st to 15th centuries CE)","authors":"Aarón Morquecho Izquier ,&nbsp;Rebeca García González ,&nbsp;Elías Sánchez Cañadillas ,&nbsp;Jonathan Santana","doi":"10.1016/j.archoralbio.2025.106236","DOIUrl":"10.1016/j.archoralbio.2025.106236","url":null,"abstract":"<div><div>Objective:</div><div>This study examines oral health conditions in the pre-European Amazigh population of the Canary Islands (1st–15th centuries) to uncover patterns linked to island-specific environments and subsistence practices. The Canary Islands offered diverse ecological settings that shaped how the Amazigh adapted their agricultural practices, creating landscapes to support settlement.</div><div>Design:</div><div>By analyzing the oral health of 615 adult individuals across seven major islands—including caries, dental wear, calculus, periodontal disease, and antemortem tooth loss—the study identifies three distinct patterns of oral health within the archipelago.</div><div>Results:</div><div>Gran Canaria exhibited the highest prevalence of dental caries, aligning with an agriculture-centered lifestyle. In contrast, La Gomera, Fuerteventura, and Lanzarote showed the lowest caries rates, suggesting less agricultural dependence. El Hierro and La Palma populations presented both high caries prevalence and extensive dental wear, likely due to a diet including famine-related foods like fern roots. The findings also indicate sex-based differences in oral health across islands but no significant distinctions by age.</div><div>Conclusions:</div><div>These patterns highlight a relationship between the diverse biogeography of the islands, subsistence strategies, and oral health in the Amazigh period. This study contributes valuable insights into how different environments and resource availability impacted the diet and health of the Canary Islands’ Amazigh populations.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106236"},"PeriodicalIF":2.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Archives of oral biology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1