Brian Lenhart, Xiaojun Wei, Zehui Zhang, Xiaoqin Wang, Qian Wang, Chang Liu
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引用次数: 5
Abstract
Since its conception as an applied biomedical technology nearly 30 years ago, nanopore is emerging as a promising, high-throughput, biomarker-targeted diagnostic tool for clinicians. The attraction of a nanopore-based detection system is its simple, inexpensive, robust, user-friendly, high-throughput blueprint with minimal sample preparation needed prior to analysis. The goal of clinical-based nanopore biosensing is to go from sample acquisition to a meaningful readout quickly. The most extensive work in nanopore applications has been targeted at DNA, RNA, and peptide identification. Although, biosensing of pathological biomarkers, which is covered in this review, is on the rise. This review is broken into two major sections: (i) the current state of existing biological, solid state, and hybrid nanopore systems and (ii) the applications of nanopore biosensors toward detecting neurodegenerative biomarkers.
期刊介绍：
Biomedical engineering has been characterized as the application of concepts drawn from engineering, computing, communications, mathematics, and the physical sciences to scientific and applied problems in the field of medicine and biology. Concepts and methodologies in biomedical engineering extend throughout the medical and biological sciences. This journal attempts to critically review a wide range of research and applied activities in the field. More often than not, topics chosen for inclusion are concerned with research and practice issues of current interest. Experts writing each review bring together current knowledge and historical information that has led to the current state-of-the-art.
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