The Efficacy of Amniotic Membrane Stem Cell (AMSC) Metabolite Product and Vitamin E for Wrinkles, Spots, and Pores in Photoaging.

IF 1.5 Q3 DERMATOLOGY Dermatology Research and Practice Pub Date : 2020-08-26 eCollection Date: 2020-01-01 DOI:10.1155/2020/1584541

Rahmadewi Rahmadewi, Retha Retha, Dyah Ayu Pitasari, Vidyani Adiningtyas Kusumastanto, Agatha Anindita Ayu Ardhaninggar, Irmadita Citrashanty, Maylita Sari, Menul Ayu Umborowati, Cita Rosita Sigit Prakoeswa

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引用次数: 5

Abstract

Background: It is expected that a combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO₂ laser as laser-assisted drug delivery (LADD) will provide better effects in photoaging treatment as the combination reaches the target. This promises an option for photoaging therapy in the future.

Materials and methods: Sixty women with photoaged skins were involved in this experimental study. They were then divided into two groups. The treatment group received a topical combination of AMSC-MP and vitamin E, and the control group received AMSC-MP alone after fractional CO₂ laser. The treatment was repeated three times.

Result: The Janus assessment results showed a significant difference in pores in the third observation, and the average pore improvements in the treatment group were better than the control group. Wrinkle, UV spot, and polar spot did not show any significant difference.

Conclusion: A combination of the amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO₂ laser as LADD only improves pores in photoaged skins.

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羊膜干细胞(AMSC)代谢物和维生素E对光老化中皱纹、斑点和毛孔的作用。

背景:期望将羊膜干细胞代谢物(AMSC-MP)与维生素E联合作为激光辅助给药(LADD)，当联合达到靶点时，在光老化治疗中提供更好的效果。这有望成为未来光老化疗法的一种选择。材料与方法:选取60例皮肤光老化女性为实验对象。然后他们被分成两组。治疗组给予AMSC-MP联合维生素E局部治疗，对照组在CO2分次激光治疗后单独给予AMSC-MP治疗。治疗重复三次。结果:Janus评估结果显示，第三次观察时毛孔有显著差异，治疗组平均毛孔改善优于对照组。皱纹、紫外线斑和极斑无显著性差异。结论:分数CO2激光后羊膜干细胞代谢物(AMSC-MP)与维生素E联合作为LADD仅能改善光老化皮肤的毛孔。

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