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Treatment of Melasma With Q-Switched Laser in Combination With Tranexamic Acid.
IF 1.5 Q3 DERMATOLOGY Pub Date : 2025-02-05 eCollection Date: 2025-01-01 DOI: 10.1155/drp/1883760
Zirui Liu

Melasma, a pigmentary disorder that particularly affects Asian women, has been clinically proven to respond effectively to combination therapy of Q-switched lasers and tranexamic acid (TXA), especially with the advancements in laser aesthetics in recent years. However, treatment outcomes can be influenced by factors such as the wavelength and spot size of the Q-switched laser, the route of administration for TXA (including injectable, oral, or topical), as well as the dosage and duration of treatment. This article presents 13 different combination approaches from six randomized controlled trials, indicating that oral administration of TXA in combination with a 1064 nm Q-switched laser is currently the most widely used and effective treatment approach.

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引用次数: 0
Acrocyanosis: The Least Known Acrosyndrome Revisited With a Dermatologic Perspective.
IF 1.5 Q3 DERMATOLOGY Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.1155/drp/2904301
Deniz Demircioğlu, Emel Öztürk Durmaz

Background: Acrocyanosis is a functional peripheral vascular disorder, currently categorized under the canopy of acrosyndromes, i.e., a group of clinically similar and significantly overlapping vascular disorders involving the acral skin. The disorder might be primary or secondary, depending on the cause. Recently, there has been a remarkable surge in acrocyanosis prevalence along with the COVID-19 pandemic. Both COVID-19 infection and vaccines for COVID-19 have been affixed to the list of disorders instigating acrocyanosis. Objectives: The goal of this narrative review was to evaluate the existing literature, project acrocyanosis from the viewpoint of dermatologists in the face of the COVID-19 pandemic, and assess the need for targeted research, education, and/or clinical practice. Methods: An English literature search was conducted using PubMed and Google. All abstracts on acrocyanosis, irrespective of the article type and publication date, were retrieved and reviewed and those most relevant for the focus of this article were selected and summarized. Discussion/Results: A narrative review was carried out. There is paucity of randomized, double-blind, placebo-controlled studies on acrocyanosis in the English literature, implicating the need for targeted research. Pertinent information still relies on anecdotal observations, case reports, case series, or scarce reviews, which are dated rather old and published in vascular-oriented journals. The scarcity of published literature on acrocyanosis in dermatology-oriented journals points to the necessity of professional education and improvement of clinical diagnostic skills for dermatologists. Conclusions: Although acrocyanosis is the least known and the least studied acrosyndrome, it is increasingly more commonly confronted in the COVID-19 era. The diagnosis still largely relies on clinical findings. Accordingly, it has become a growing necessity for a dermatologist to remain updated on this peculiar disorder and be able to differentiate acrocyanosis from clinically similar cold-induced or cold-exacerbated acrosyndromes. Acrocyanosis is still misdiagnosed, underdiagnosed, underreported, and undertreated by the dermatology community.

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引用次数: 0
Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis. 儿童特应性皮炎患者角质层水化和经皮失水的区域特异性评估。
IF 1.5 Q3 DERMATOLOGY Pub Date : 2025-01-13 eCollection Date: 2025-01-01 DOI: 10.1155/drp/2376970
Bo Yeon Kwon, Dohyeong Kim, Kyungmin Shim, Cindy Nguyen, Hee Chul Lee, Daeshik Kang, Hohyun Kim, SungChul Seo

SCORring atopic dermatitis (SCORAD) is widely used to assess the severity of atopic eczema, but score systems based on the entire body may be limited in effective monitoring and intervention. It is crucial to monitor moisture levels in each affected body part, but empirical research is still lacking. The objective of this study was to analyze the levels of stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in atopic dermatitis (AD) patients, focusing on the presence and location of atopic lesions at different body sites. The levels of TEWL and SCH were measured using the AF200 AquaFlux and the Corneometer, respectively, at 15 body sites. 98 children under the age of 10 were measured, including 83 AD patients and 15 in the control group. Patients were also assessed with SCORAD and for the presence of atopic lesions at each body site. 58.7% of AD patients had lesions in the antecubital fossa and popliteal fossa, with corresponding low SCH levels and high TEWL in the upper body. The differences in TEWL between the control group and AD patients were confirmed significant in the neck and antecubital fossa regions, while differences in SCH were identified in the face, antecubital fossa, and popliteal fossa regions. A higher TEWL was found among AD patients with atopic lesions in the face and ankle. This study suggests that continuous monitoring of SCH and TEWL levels at specific body sites can provide insights into identifying vulnerable body areas to AD and supplement the SCORAD system for more effective clinical intervention and prevention strategies.

特应性皮炎评分(SCORAD)被广泛用于评估特应性湿疹的严重程度,但基于全身的评分系统在有效监测和干预方面可能受到限制。监测每个受影响身体部位的水分水平是至关重要的,但实证研究仍然缺乏。本研究的目的是分析特应性皮炎(AD)患者角质层水化(SCH)和经皮失水(TEWL)水平,重点研究特应性皮炎在不同身体部位的存在和位置。分别使用AF200 AquaFlux和Corneometer在15个身体部位测量TEWL和SCH水平。对98名10岁以下儿童进行了测量,其中AD患者83例,对照组15例。还对患者进行了SCORAD评估,并评估了每个身体部位是否存在特应性病变。58.7%的AD患者病变位于肘前窝和腘窝,相应的上半身SCH水平低,TEWL高。对照组与AD患者TEWL在颈部和枕前窝区域差异显著,而SCH在面部、枕前窝和腘窝区域差异显著。面部和踝关节有特应性病变的AD患者TEWL较高。该研究表明,持续监测特定身体部位的SCH和TEWL水平可以帮助我们识别AD的易感身体部位,并补充SCORAD系统,为更有效的临床干预和预防策略提供帮助。
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引用次数: 0
The Role of Moisturizer Containing Anti-inflammatory on Skin Hydration in Mild-Moderate Atopic Dermatitis Patients. 含抗炎保湿剂对轻、中度特应性皮炎患者皮肤水合作用的研究。
IF 1.5 Q3 DERMATOLOGY Pub Date : 2024-12-23 eCollection Date: 2024-01-01 DOI: 10.1155/drp/3586393
Cita Rosita Sigit Prakoeswa, Damayanti, Sylvia Anggraeni, Menul Ayu Umborowati, Maylita Sari, Made Putri Hendaria, Tanziela Firdausi Thahir

Atopic dermatitis (AD) is a chronic, inflammatory skin condition characterized by eczema lesions and dry, itchy skin. Recent guidelines for the management of AD emphasize the importance of using moisturizers in the management of AD. This study is a double-blind clinical trial to determine the effectiveness of moisturizers containing anti-inflammatory ingredients compared with moisturizers without anti-inflammatory ingredients for skin hydration in mild to moderate adult AD patients for 14 days at the Dermatology and Venereology Outpatient Clinic at Dr. Soetomo General Academic Hospital. There was a significant difference (p < 0.05) at the baseline and day 14 skin hydration values in the experiment group with anti-inflammatory ingredients (35.97 ± 6.04-66.06 ± 15.84) and the control group without anti-inflammatory ingredients (40.74 ± 10.94-56.12 ± 8.34). After comparison, there was a significant difference (p < 0.05) in the skin hydration value between the experiment group and the control group on the 14th day. There was also a significant difference in the improvement of skin hydration outcomes between both groups (p < 0.05). The severity of the disease using Scoring Atopic Dermatitis (SCORAD) showed a significant difference (p < 0.05) between the experiment group and the control group after 2 weeks of intervention. The addition of anti-inflammatory ingredients in the moisturizer, namely, shea butter, bacterial lysate, allantoin, bisabolol, Phragmites kharka extract, Poria cocos, and Mirabilis jalapa in a moisturizer containing occlusive (dimethicone), humectants (glycerin, saccharide, butylene glycol, and hyaluronic acid), and emollient (shea butter and squalane) was shown to be significantly better in improving skin hydration in patients with mild to moderate AD.

特应性皮炎(AD)是一种慢性炎症性皮肤病,其特征是湿疹病变和皮肤干燥、发痒。最近的AD管理指南强调了在AD管理中使用保湿剂的重要性。本研究是一项双盲临床试验,旨在确定含有抗炎成分的保湿剂与不含抗炎成分的保湿剂对轻度至中度成年AD患者皮肤水合作用的有效性,该试验在Dr. Soetomo综合学术医院皮肤科和性病门诊进行,为期14天。试验组在基线和第14天皮肤水合值(35.97±6.04-66.06±15.84)与对照组(40.74±10.94-56.12±8.34)差异有统计学意义(p < 0.05)。经比较,第14天试验组与对照组的皮肤水合值差异有统计学意义(p < 0.05)。两组患者皮肤水合效果的改善也有显著差异(p < 0.05)。干预2周后,试验组与对照组对特应性皮炎(scoad)评分的疾病严重程度差异有统计学意义(p < 0.05)。在含有封闭剂(二甲硅氧烷)、保湿剂(甘油、糖、丁二甘醇和透明质酸)和润肤剂(乳木果油和角鲨烷)的保湿霜中添加抗炎成分,即乳木果油、细菌溶出物、尿囊素、bisabolol、芦苇提取液、茯苓和Mirabilis jalapa,可以显著改善轻度至中度AD患者的皮肤水合性。
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引用次数: 0
Assessment of Depressive and Anxiety Symptoms and Health-Related Quality of Life in Rosacea Patients: A Case-Control Study. 酒渣鼻患者抑郁、焦虑症状与健康相关生活质量的评估:一项病例对照研究
IF 1.5 Q3 DERMATOLOGY Pub Date : 2024-12-07 eCollection Date: 2024-01-01 DOI: 10.1155/drp/5532532
Khaled Seetan, Mohammad Gablan, Mohammad Alnaimi, Daleen Alhazaimeh, Mohammad Bani Younes, Ahmad Alnaimi, Almutazballlah Qablan

Background: Rosacea, a chronic facial dermatosis, poses a substantial global prevalence burden. Its impact extends beyond physical symptoms, affecting patient quality of life, self-esteem, and psychosocial functioning. This study aims to assess the health-related quality of life and emotional well-being in Jordanian rosacea patients in comparison to healthy controls. Methods: A case-control study, matching for age and sex, was conducted among rosacea patients attending the outpatient department at a governmental secondary hospital in the north of Jordan between September 2022 and November 2023. Adult patients with a confirmed rosacea diagnosis for a duration of ≥ 3 months were paired with healthy controls. Health-related quality of life, anxiety, and depression were evaluated using the Dermatology Life Quality Index (DLQI) and the Hospital Anxiety and Depression Scale (HADS), respectively. Disease severity was assessed using the Clinician's Erythema Assessment (CEA) grading system. Results: The study included 198 rosacea patients and 198 healthy controls. Rosacea patients exhibited significantly higher DLQI scores (mean 11.32 ± 5.4) compared to controls (mean 4.28 ± 2.3), indicating diminished quality of life. Subscale analysis revealed prominent differences in symptoms/feelings and daily activities. Additionally, rosacea patients reported elevated scores on the HADS anxiety (mean 9.38 ± 3.2) and depression (mean 8.19 ± 4.3) subscales in contrast to controls (mean 3.88 ± 2.18 and mean 3.41 ± 1.87, respectively). More than half (57%) of rosacea patients experienced moderate or severe anxiety, and nearly a third (31%) reported moderate or severe depression. Regression analyses revealed that higher disease severity significantly predicted worse quality of life (β = 0.384), anxiety (β = 0.352), and depression (β = 0.312). Conclusion: The study demonstrated that rosacea patients in Jordan experience significantly diminished quality of life and higher rates of anxiety and depression compared to healthy controls. Disease severity and multiple facial lesions emerged as strong predictors of poor psychological outcomes, while female gender increased vulnerability and longer disease duration showed a protective effect. These findings emphasize the need for routine psychological screening and a holistic treatment approach, particularly for newly diagnosed patients with severe disease manifestations.

背景:酒渣鼻是一种慢性面部皮肤病,是一种全球性的流行疾病。它的影响超出了身体症状,影响患者的生活质量、自尊和社会心理功能。本研究旨在评估约旦酒渣鼻患者的健康相关生活质量和情绪健康状况,并与健康对照组进行比较。方法:对2022年9月至2023年11月在约旦北部一家政府二级医院门诊部就诊的酒渣鼻患者进行年龄和性别匹配的病例对照研究。确诊酒渣鼻≥3个月的成年患者与健康对照者配对。分别使用皮肤科生活质量指数(DLQI)和医院焦虑抑郁量表(HADS)评估与健康相关的生活质量、焦虑和抑郁。使用临床医生红斑评估(CEA)分级系统评估疾病严重程度。结果:本研究纳入198例酒渣鼻患者和198例健康对照。酒渣鼻患者DLQI评分(平均11.32±5.4)明显高于对照组(平均4.28±2.3),表明生活质量下降。分量表分析显示在症状/感觉和日常活动方面存在显著差异。此外,酒渣鼻患者在HADS焦虑(平均9.38±3.2)和抑郁(平均8.19±4.3)亚量表上的得分高于对照组(平均3.88±2.18和3.41±1.87)。超过一半(57%)的酒渣鼻患者经历中度或重度焦虑,近三分之一(31%)的患者报告中度或重度抑郁。回归分析显示,疾病严重程度越高,生活质量(β = 0.384)、焦虑(β = 0.352)和抑郁(β = 0.312)越差。结论:研究表明,约旦的酒渣鼻患者的生活质量明显下降,焦虑和抑郁的发生率高于健康对照组。疾病严重程度和多发性面部病变是不良心理结果的有力预测因素,而女性的脆弱性增加和疾病持续时间延长显示出保护作用。这些发现强调了常规心理筛查和整体治疗方法的必要性,特别是对新诊断的有严重疾病表现的患者。
{"title":"Assessment of Depressive and Anxiety Symptoms and Health-Related Quality of Life in Rosacea Patients: A Case-Control Study.","authors":"Khaled Seetan, Mohammad Gablan, Mohammad Alnaimi, Daleen Alhazaimeh, Mohammad Bani Younes, Ahmad Alnaimi, Almutazballlah Qablan","doi":"10.1155/drp/5532532","DOIUrl":"10.1155/drp/5532532","url":null,"abstract":"<p><p><b>Background:</b> Rosacea, a chronic facial dermatosis, poses a substantial global prevalence burden. Its impact extends beyond physical symptoms, affecting patient quality of life, self-esteem, and psychosocial functioning. This study aims to assess the health-related quality of life and emotional well-being in Jordanian rosacea patients in comparison to healthy controls. <b>Methods:</b> A case-control study, matching for age and sex, was conducted among rosacea patients attending the outpatient department at a governmental secondary hospital in the north of Jordan between September 2022 and November 2023. Adult patients with a confirmed rosacea diagnosis for a duration of ≥ 3 months were paired with healthy controls. Health-related quality of life, anxiety, and depression were evaluated using the Dermatology Life Quality Index (DLQI) and the Hospital Anxiety and Depression Scale (HADS), respectively. Disease severity was assessed using the Clinician's Erythema Assessment (CEA) grading system. <b>Results:</b> The study included 198 rosacea patients and 198 healthy controls. Rosacea patients exhibited significantly higher DLQI scores (mean 11.32 ± 5.4) compared to controls (mean 4.28 ± 2.3), indicating diminished quality of life. Subscale analysis revealed prominent differences in symptoms/feelings and daily activities. Additionally, rosacea patients reported elevated scores on the HADS anxiety (mean 9.38 ± 3.2) and depression (mean 8.19 ± 4.3) subscales in contrast to controls (mean 3.88 ± 2.18 and mean 3.41 ± 1.87, respectively). More than half (57%) of rosacea patients experienced moderate or severe anxiety, and nearly a third (31%) reported moderate or severe depression. Regression analyses revealed that higher disease severity significantly predicted worse quality of life (<i>β</i> = 0.384), anxiety (<i>β</i> = 0.352), and depression (<i>β</i> = 0.312). <b>Conclusion:</b> The study demonstrated that rosacea patients in Jordan experience significantly diminished quality of life and higher rates of anxiety and depression compared to healthy controls. Disease severity and multiple facial lesions emerged as strong predictors of poor psychological outcomes, while female gender increased vulnerability and longer disease duration showed a protective effect. These findings emphasize the need for routine psychological screening and a holistic treatment approach, particularly for newly diagnosed patients with severe disease manifestations.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"5532532"},"PeriodicalIF":1.5,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological Patterns of Cutaneous and Mucocutaneous Leishmaniasis Due to L. aethiopica. 由衣索比亚乳杆菌引起的皮肤和粘膜利什曼病的组织病理学模式。
IF 1.5 Q3 DERMATOLOGY Pub Date : 2024-11-29 eCollection Date: 2024-01-01 DOI: 10.1155/drp/5267606
Abay Atnafu, Zewditu Chanyalew, Sofia Yimam, Meaza Zeleke, Shimelis Negussie, Selfu Girma, Aklilu Melaku, Menberework Chanyalew

Background: Cutaneous leishmaniasis (CL) is an endemic disease in Ethiopia, mainly caused by L. aethiopica. Limited reports are available related to histopathological features of the skin lesion caused by L. aethiopica. This study aimed to analyze the histopathological features of CL due to L. aethiopica. Materials and Methods: A similar cohort polymerase chain reaction (PCR) confirmed CL patients from a previous own study, who were prospectively enrolled from All Africa Leprosy, Tuberculosis and Rehabilitation Training (ALERT) Hospital Addis Ababa, Kela Health Center in Gurage Zone, Siliti Health Center in Silit zone of southern nations and nationalities, as well as Ankober Health Center in Amhara region was used for data analysis. The histopathology was analyzed by performing hematoxylin and eosin (H&E) staining to look for the presence of general and specific histopathology patterns of the disease. Descriptive statistics was utilized using SPSS version 26.0 (SPSS, Inc., Chicago, United States of America). Results: Amastigotes were observed in skin biopsies of 29% (n = 2) mucocutaneous leishmaniasis (MCL) and 58% (n = 6) localized cutaneous leishmaniasis (LCL) patients. Diffused inflammatory cell infiltrate was observed in the dermal compartment of 77% (n = 20) samples while the remaining 23% (n = 6) had patchy or nodular inflammatory cell infiltrate. The dominant type of inflammatory cell infiltrate in the dermal compartments is macrophages and lymphocytes with a similar proportion, 23/26 (88.5%), followed by plasma cells, 21/26 (80.8%). Among all cases, 38.5% (n = 10) of them were categorized under the Type I pattern while Types IV and V patterns were reported in 26.9% (n = 7) and 34.6% (n = 9) of the remaining samples, respectively. The study found statistically significant correlations between necrosis and MCL (p=0.01), unorganized granulomas and LCL (p=0.04), and the presence of eosinophils and giant cell Langerhans with MCL (p=0.002 and p < 0.001, respectively). Conclusion: In our study, the histopathological patterns of the CL caused by L. aethiopica were shown to have a dermal change that was characterized by a domination of diffused inflammatory cell infiltrate. Most of the cell types in the infiltrate were macrophages and lymphocytes. In addition, amastigote resided in the histiocyte with a varying degree of intensity, and both the organized and unorganized granulomas were shown with a considerable proportion.

背景:皮肤利什曼病是埃塞俄比亚的一种地方病,主要由埃塞俄比亚利什曼杆菌引起。有限的报告是可用的有关组织病理学特征的皮肤病变引起的乳杆菌。本研究旨在分析埃塞俄比亚乳杆菌引起的CL的组织病理学特征。材料和方法:采用类似的队列聚合酶链反应(PCR)证实了先前自己的一项研究中的CL患者,这些患者来自亚的斯亚贝巴的全非洲麻风、结核病和康复培训(ALERT)医院、古拉格地区的Kela卫生中心、南部国家和民族Silit地区的Siliti卫生中心以及阿姆哈拉地区的Ankober卫生中心。通过苏木精和伊红(H&E)染色分析组织病理学,以寻找疾病的一般和特定组织病理学模式的存在。描述性统计使用SPSS 26.0版本(SPSS, Inc., Chicago, United States)。结果:29% (n = 2)皮肤粘膜利什曼病(MCL)患者和58% (n = 6)局部皮肤利什曼病(LCL)患者的皮肤活检中检出无毛线虫。77% (n = 20)的样本在真皮间室可见弥漫性炎症细胞浸润,其余23% (n = 6)的样本可见斑片状或结节性炎症细胞浸润。真皮间室炎症细胞浸润的主要类型是巨噬细胞和淋巴细胞,比例相似,为23/26(88.5%),其次是浆细胞,为21/26(80.8%)。在所有病例中,38.5% (n = 10)的病例属于I型,其余样本中分别有26.9% (n = 7)和34.6% (n = 9)属于IV型和V型。研究发现,坏死与MCL (p=0.01)、无组织肉芽肿与LCL (p=0.04)、嗜酸性粒细胞和巨细胞朗格汉斯与MCL (p=0.002和p < 0.001)存在统计学意义上的相关性。结论:在我们的研究中,由埃塞俄比亚乳杆菌引起的CL的组织病理学模式显示出以弥漫性炎症细胞浸润为主的皮肤变化。浸润细胞以巨噬细胞和淋巴细胞为主。此外,无梭体以不同程度的强度驻留在组织细胞中,有组织和无组织肉芽肿均占相当比例。
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引用次数: 0
The Efficacy of Sample Storage Envelopes in Collecting Scales From the Skin and Nails for Mycology Laboratory Diagnosis of Superficial Fungal Infection. 样本存储信封在采集皮肤和指甲鳞片用于真菌学实验室诊断浅部真菌感染中的功效
IF 1.5 Q3 DERMATOLOGY Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI: 10.1155/2024/6325772
Lalita Matthapan, Sumanas Bunyaratavej, Charussri Leeyaphan, Pantaree Kobkurkul, Thrit Hutachoke, Supisara Wongdama, Suthasanee Prasertsook, Bawonpak Pongkittilar, Chatisa Panyawong, Waranyoo Prasong, Akkarapong Plengpanich

Background: Fungal cultures are unavailable in many hospitals. The development of an effective sample storage solution for timely transportation would improve management of patients with superficial fungal skin and nail infections. Objectives: This study aimed to evaluate the efficacy of sample storage envelopes to preserve skin and nail samples for timely microscopic examination and culture for superficial fungal infections. Methods: Patients aged 18 years and above with suspected superficial fungal infections were enrolled. The samples were divided into four envelopes. The baseline 20% potassium hydroxide (KOH) examination and fungal culture served as reference points. The stored samples were reexamined on Days 3, 7, 14, and 28. Results: The study included 90 patients with suspected superficial fungal infections (45 skin and 45 nail lesions). Reference KOH examinations showed branching septate hyphae in 36 (80.0%) for skin and 35 (77.8%) for nail infections. Reference fungal cultures were positive for the growth of dermatophyte and nondermatophyte molds in 34 (75.6%) and 28 (62.2%) in skin and nail infections, respectively. Sample storage envelopes maintained 100% sensitivity and specificity for up to 28 days with KOH examination for both skin and nail samples. On Day 28, the fungal culture sensitivity was 70.6% for the skin and 64.3% for the nail samples, with specificities of 100.0% and 88.2%, respectively. Conclusions: Sample storage envelopes effectively maintained diagnostic accuracy for up to 28 days with KOH examination for both skin and nail samples. Given the high specificity even on Day 28 for fungal culture, transferring samples within 28 days remains a reliable practice.

背景:许多医院无法提供真菌培养物。开发一种有效的样本储存解决方案,以便及时运送样本,将改善对皮肤和指甲浅表真菌感染患者的管理。研究目的本研究旨在评估样本存储信封在保存皮肤和指甲样本以便及时进行显微镜检查和培养以治疗浅表真菌感染方面的功效。研究方法招募 18 岁及以上疑似浅表真菌感染患者。样本分为四个信封。20%氢氧化钾(KOH)基线检查和真菌培养作为参考点。在第 3、7、14 和 28 天对保存的样本进行复检。研究结果该研究包括 90 名疑似浅表真菌感染患者(45 名皮肤病患者和 45 名指甲病变患者)。参考 KOH 检验结果显示,36 例(80.0%)皮肤感染和 35 例(77.8%)指甲感染患者的真菌菌丝呈分枝状隔膜。参考真菌培养结果显示,皮肤和指甲感染中分别有 34 例(75.6%)和 28 例(62.2%)皮肤癣菌和非皮肤癣菌霉菌生长呈阳性。在对皮肤和指甲样本进行长达 28 天的 KOH 检验后,样本保存信封仍能保持 100% 的灵敏度和特异性。在第 28 天,皮肤和指甲样本的真菌培养敏感性分别为 70.6%和 64.3%,特异性分别为 100.0% 和 88.2%。结论在对皮肤和指甲样本进行 KOH 检验时,样本保存信封可有效保持诊断准确性长达 28 天。鉴于即使在第 28 天进行真菌培养也有很高的特异性,因此在 28 天内转移样本仍然是一种可靠的做法。
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引用次数: 0
Topical Vitamin D3 Derivative (Calcipotriol) Versus Intralesional Vitamin D3 in the Treatment of Cutaneous Warts: A Clinical Therapeutic Comparative Trial. 治疗皮肤疣的外用维生素 D3 衍生物(钙泊三醇)与内服维生素 D3:临床治疗比较试验》。
IF 1.5 Q3 DERMATOLOGY Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5236290
Rand A Almuhyi, Khalil I Alhamdi, Dooha K Alhamdi

Background: Cutaneous warts are epidermal proliferations caused by human papillomavirus. There are a variety of treatment options for warts with different success rates. Intralesional vitamin D3 injection is an innovative treatment option for warts, and several studies have examined its efficacy. To the best of our knowledge, this is the first study to compare the two modalities of vitamin D3 in wart treatment. Objective: To evaluate and compare the efficacy of topical vitamin D3 derivative (calcipotriol) and intralesional vitamin D3 in the treatment of warts. Patients and Methods: This is an open-label, therapeutic, comparative, clinical study involving 56 patients with warts. The patients were randomly divided into two equal groups (n = 28). Group A was treated with topical calcipotriol ointment (0.005%) twice daily for a period of 8 weeks, while Group B was treated with intralesional injection of 0.2-0.3 mL of vitamin D3 (300,000 I.U. per ampule) for 4 sessions (2 weeks apart). The patients were followed every 2 weeks during treatment and then 3 months after the last visit. Results: The percentage of patients who showed a complete response in Group A was higher than that of Group B (95% vs. 59%). Furthermore, 9 patients out of 13 (69.2%) who showed a complete response in Group B required a period of 8 weeks, while only 2 patients out of 21 (9.5%) in Group A required the same period. In addition, side effects were more in Group B. Moreover, no recurrence was observed in Group A, while in Group B, it was seen in 2 (11%) patients. Conclusions: Both topical and intralesional vitamin D3 are effective in the treatment of warts, with topical vitamin D3 having better efficacy, faster, less side effects, and less risk of recurrence.

背景:皮肤疣是由人类乳头瘤病毒引起的表皮增生。治疗尖锐湿疣的方法多种多样,成功率也各不相同。鞘内注射维生素 D3 是治疗尖锐湿疣的一种创新疗法,已有多项研究探讨了其疗效。据我们所知,这是第一项比较两种维生素 D3 治疗尖锐湿疣方法的研究。研究目的评估并比较外用维生素 D3 衍生物(钙泊三醇)和鞘内维生素 D3 治疗尖锐湿疣的疗效。患者和方法:这是一项涉及 56 名尖锐湿疣患者的开放标签、治疗、比较临床研究。患者被随机分为两组(28 人)。A 组接受外用钙泊三醇软膏(0.005%)治疗,每天两次,为期 8 周;B 组接受维生素 D3(每安瓿 30 万 I.U.)鞘内注射治疗,每次 0.2-0.3 毫升,共 4 次(每次间隔 2 周)。治疗期间每两周对患者进行一次随访,最后一次随访后 3 个月进行随访。结果显示A 组患者完全应答的比例高于 B 组(95% 对 59%)。此外,B 组 13 名患者中有 9 名(69.2%)完全康复,需要 8 周时间,而 A 组 21 名患者中只有 2 名(9.5%)需要 8 周时间。此外,B 组的副作用更大。此外,A 组没有发现复发,而 B 组有 2 名患者(11%)复发。结论外用和鞘内注射维生素 D3 对治疗尖锐湿疣都有效,其中外用维生素 D3 的疗效更好、更快、副作用更少、复发风险更低。
{"title":"Topical Vitamin D<sub>3</sub> Derivative (Calcipotriol) Versus Intralesional Vitamin D<sub>3</sub> in the Treatment of Cutaneous Warts: A Clinical Therapeutic Comparative Trial.","authors":"Rand A Almuhyi, Khalil I Alhamdi, Dooha K Alhamdi","doi":"10.1155/2024/5236290","DOIUrl":"https://doi.org/10.1155/2024/5236290","url":null,"abstract":"<p><p><b>Background:</b> Cutaneous warts are epidermal proliferations caused by human papillomavirus. There are a variety of treatment options for warts with different success rates. Intralesional vitamin D<sub>3</sub> injection is an innovative treatment option for warts, and several studies have examined its efficacy. To the best of our knowledge, this is the first study to compare the two modalities of vitamin D<sub>3</sub> in wart treatment. <b>Objective:</b> To evaluate and compare the efficacy of topical vitamin D<sub>3</sub> derivative (calcipotriol) and intralesional vitamin D<sub>3</sub> in the treatment of warts. <b>Patients and Methods:</b> This is an open-label, therapeutic, comparative, clinical study involving 56 patients with warts. The patients were randomly divided into two equal groups (<i>n</i> = 28). Group A was treated with topical calcipotriol ointment (0.005%) twice daily for a period of 8 weeks, while Group B was treated with intralesional injection of 0.2-0.3 mL of vitamin D<sub>3</sub> (300,000 I.U. per ampule) for 4 sessions (2 weeks apart). The patients were followed every 2 weeks during treatment and then 3 months after the last visit. <b>Results:</b> The percentage of patients who showed a complete response in Group A was higher than that of Group B (95% vs. 59%). Furthermore, 9 patients out of 13 (69.2%) who showed a complete response in Group B required a period of 8 weeks, while only 2 patients out of 21 (9.5%) in Group A required the same period. In addition, side effects were more in Group B. Moreover, no recurrence was observed in Group A, while in Group B, it was seen in 2 (11%) patients. <b>Conclusions:</b> Both topical and intralesional vitamin D<sub>3</sub> are effective in the treatment of warts, with topical vitamin D<sub>3</sub> having better efficacy, faster, less side effects, and less risk of recurrence.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"5236290"},"PeriodicalIF":1.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Study of Demographic and Clinical Criteria Between Male and Female Patients With Pemphigus Referred to a Referral Hospital in Iran. 伊朗一家转诊医院转诊的丘疹性荨麻疹男女患者人口统计学和临床标准比较研究。
IF 1.5 Q3 DERMATOLOGY Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9572303
Zeinab Aryanian, Kamran Balighi, Nafiseh Esmaeli, Maryam Daneshpazhooh, Nasim Mazloomi Tootoonchi, Zahra Razavi, Fereshteh Beigmohammadi, Umamah Gul, Azadeh Khayyat, Parvaneh Hatami

Background: Pemphigus is a rare autoimmune disease characterized by the formation of blisters on the skin and mucous membranes, caused by autoantibodies against desmoglein, a key protein in cell adhesion. This study aims to compare demographic and clinical criteria between male and female patients with pemphigus referred to a referral hospital, utilizing data from the pemphigus diseases registry. Method: This retrospective cross-sectional analysis focused on several key aspects age at disease onset, severity (measured by the Pemphigus Disease Area Index [PDAI]), types of pemphigus, duration of disease, and diagnostic criteria including the presence of antidesmoglein antibodies and findings from direct immunofluorescence (DIF). By examining these variables among a cohort selected based on their diagnosis of pemphigus, the study aimed to identify significant gender differences in disease manifestation, diagnosis, and progression. This approach is crucial for tailoring more effective gender-specific management and treatment strategies for this rare autoimmune condition. Results: In a comprehensive analysis of 1218 pemphigus patients in the year 2021 from the hospital's registry, comprising 543 males (44.6%) and 675 females (55.4%), significant gender differences were identified in 9 out of 44 variables examined. The study revealed that males had a higher age at disease onset, more frequent clinical manifestations in the head, neck, and trunk areas, and greater severity of disease as measured by the PDAI score compared to females. Conversely, females exhibited higher instances of mucosal manifestations and a higher PDAI score for mucosal erosion blister of the lower gingiva. No significant gender differences were found in 21 variables, including the overall age of patients, specific clinical manifestations across various mucous membranes, types of pemphigus, and PDAI scores for mucosal erosions in particular locations, indicating a nuanced gender impact on the presentation and severity of pemphigus that necessitates tailored clinical approaches. Conclusion: The study highlights significant gender differences in the presentation and severity of pemphigus, underscoring the importance of gender-specific approaches in the diagnosis and management of this condition. The findings contribute valuable insights into the complex nature of pemphigus and underline the necessity for further research to understand the underlying mechanisms driving these differences.

背景:丘疹性荨麻疹是一种罕见的自身免疫性疾病,其特征是在皮肤和粘膜上形成水疱,由针对去疱疹素(一种细胞粘附的关键蛋白)的自身抗体引起。本研究旨在利用丘疹性荨麻疹疾病登记数据,比较转诊到一家医院的丘疹性荨麻疹男女患者的人口统计学和临床标准。方法:这项回顾性横断面分析主要关注几个关键方面:发病年龄、严重程度(以丘疹性荨麻疹疾病面积指数[PDAI]衡量)、丘疹性荨麻疹类型、病程以及诊断标准,包括是否存在抗蝶形花序蛋白抗体和直接免疫荧光(DIF)结果。通过对根据丘疹性荨麻疹诊断结果选出的人群中的这些变量进行检查,该研究旨在确定在疾病表现、诊断和进展方面存在的显著性别差异。这种方法对于针对这种罕见的自身免疫性疾病制定更有效的性别管理和治疗策略至关重要。研究结果在对医院登记的 2021 年 1218 名丘疹性荨麻疹患者(包括 543 名男性(44.6%)和 675 名女性(55.4%))进行的全面分析中,在 44 个变量中的 9 个变量中发现了显著的性别差异。研究显示,与女性相比,男性的发病年龄更高,头颈部和躯干部位的临床表现更频繁,以 PDAI 评分衡量的疾病严重程度更高。相反,女性出现粘膜表现的次数更多,下牙龈粘膜糜烂水疱的 PDAI 得分更高。在患者的总体年龄、各种粘膜的具体临床表现、丘疹性荨麻疹的类型以及特定部位粘膜糜烂的 PDAI 评分等 21 个变量中,均未发现明显的性别差异。结论本研究强调了在丘疹性荨麻疹的表现形式和严重程度方面存在的显著性别差异,强调了在诊断和管理这种疾病时采取有性别针对性的方法的重要性。研究结果有助于深入了解丘疹性荨麻疹的复杂性,并强调有必要开展进一步研究,以了解导致这些差异的潜在机制。
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引用次数: 0
Morphological and Prognostic Values of Skin Lesions in Patients with COVID-19. COVID-19 患者皮肤病变的形态学和预后价值。
IF 1.5 Q3 DERMATOLOGY Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4975523
Mahmoud A Rageh, Ibrahim H E Yousef, Yaser Hosny Ali Elewa, Mofreh Mansour, Omar AbdelHady Omar Ahmed, Sameh Fawzy Fahmy, Ahmad Saeed Aladl, Mohamed Amer, Emad El Rewiny, Manar Elsayed Sallam, Amr Mohammad Ammar, Salma S Mohammed, Ahmed Shawky

The dermatological manifestations of the coronavirus cause severe acute respiratory syndrome. The current study investigates the morphological and histopathological relationship between the emergence of skin lesions and the severity of COVID-19 across the course of the disease via a cross-sectional study. There were skin lesions (maculopapular rash, vesiculobullous lesions, urticarial lesions, cutaneous thromboembolic "CT," and erythema multiforme-like lesions "EM-like") in confirmed COVID-19 instances. A total of 150 patients of both sexes were evaluated morphologically and were classified as early (44% of the total) or late based on the emergence of respiratory symptoms (one week before or two weeks after, respectively). The early and late diagnostic groups represented 44% and 56% of the total patients, respectively. Patients with no skin lesion and one skin lesion showed a significant correlation with disease timeline early and late stages (X2 = 22.38, P < 0.001; X2 = 4.432, P < 0.001, respectively). CT and EM-like were correlated with the disease severity, X2 = 50.51, P < 0.001; X2 = 19.186, P ≤ 0.001, respectively. In conclusion, our data suggested that the onset of dermatological lesions that developed during the COVID-19 pandemic may be a useful diagnostic and prognostic tool for COVID-19 severity. Therefore, a thorough examination of the skin may save time and bring physicians to an accurate diagnosis and, as a result, prompt treatment.

冠状病毒的皮肤表现会导致严重急性呼吸综合征。本研究通过横断面研究,探讨了整个病程中皮损出现与 COVID-19 严重程度之间的形态学和组织病理学关系。COVID-19确诊病例中存在皮肤病变(斑丘疹、疱疹、荨麻疹、皮肤血栓栓塞 "CT "和多形红斑样病变 "EM样")。共对 150 名男女患者进行了形态学评估,并根据呼吸道症状出现的时间(分别为一周前或两周后)分为早期(占总数的 44%)和晚期。早期和晚期诊断组分别占患者总数的 44% 和 56%。无皮损和有皮损的患者与疾病时间线早期和晚期有显著相关性(X2 = 22.38,P < 0.001;X2 = 4.432,P < 0.001)。CT 和 EM-like 与疾病严重程度相关,分别为 X2 = 50.51,P < 0.001;X2 = 19.186,P ≤ 0.001。总之,我们的数据表明,在 COVID-19 大流行期间出现的皮肤病变可能是 COVID-19 严重程度的有用诊断和预后工具。因此,对皮肤进行彻底检查可以节省时间,使医生做出准确诊断,从而及时治疗。
{"title":"Morphological and Prognostic Values of Skin Lesions in Patients with COVID-19.","authors":"Mahmoud A Rageh, Ibrahim H E Yousef, Yaser Hosny Ali Elewa, Mofreh Mansour, Omar AbdelHady Omar Ahmed, Sameh Fawzy Fahmy, Ahmad Saeed Aladl, Mohamed Amer, Emad El Rewiny, Manar Elsayed Sallam, Amr Mohammad Ammar, Salma S Mohammed, Ahmed Shawky","doi":"10.1155/2024/4975523","DOIUrl":"https://doi.org/10.1155/2024/4975523","url":null,"abstract":"<p><p>The dermatological manifestations of the coronavirus cause severe acute respiratory syndrome. The current study investigates the morphological and histopathological relationship between the emergence of skin lesions and the severity of COVID-19 across the course of the disease via a cross-sectional study. There were skin lesions (maculopapular rash, vesiculobullous lesions, urticarial lesions, cutaneous thromboembolic \"CT,\" and erythema multiforme-like lesions \"EM-like\") in confirmed COVID-19 instances. A total of 150 patients of both sexes were evaluated morphologically and were classified as early (44% of the total) or late based on the emergence of respiratory symptoms (one week before or two weeks after, respectively). The early and late diagnostic groups represented 44% and 56% of the total patients, respectively. Patients with no skin lesion and one skin lesion showed a significant correlation with disease timeline early and late stages (<i>X</i>2 = 22.38, <i>P</i> < 0.001; <i>X2</i> = 4.432, <i>P</i> < 0.001, respectively). CT and EM-like were correlated with the disease severity, <i>X</i>2 = 50.51, <i>P</i> < 0.001; <i>X</i>2 = 19.186, <i>P</i> ≤ 0.001, respectively. In conclusion, our data suggested that the onset of dermatological lesions that developed during the COVID-19 pandemic may be a useful diagnostic and prognostic tool for COVID-19 severity. Therefore, a thorough examination of the skin may save time and bring physicians to an accurate diagnosis and, as a result, prompt treatment.</p>","PeriodicalId":11338,"journal":{"name":"Dermatology Research and Practice","volume":"2024 ","pages":"4975523"},"PeriodicalIF":1.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Dermatology Research and Practice
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