The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of silver nanoparticles against Staphylococcus aureus.

Biomaterial investigations in dentistry Pub Date : 2020-07-23 DOI:10.1080/26415275.2020.1796674

Prashik Parvekar, Jayant Palaskar, Sandeep Metgud, Rahul Maria, Smita Dutta

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Abstract

Aim: To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of silver nanoparticles against Staphylococcus aureus (S. aureus).Methodology: The antimicrobial efficacy of the silver nanoparticles was determined by the standard methods of Clinical and Laboratory Standards Institute (CLSI). Different concentrations of silver nanoparticles were prepared, and MIC was calculated by tube macro-dilution method. The MBC was determined by the lowest concentration that kills 99.9% of the initial bacterial population. The data were analyzed by ANOVA and Tukey's post hoc test using SPSS software.

Results: The MIC and MBC of silver nanoparticles against S. aureus was found to be 0.625 mg/ml.

Conclusion: The result obtained from this study shows that silver nanoparticles have potential bactericidal effects against S. aureus at a concentration of 0.625 mg/ml. Silver nanoparticles can be incorporated in the root canal medicaments, sealers and irrigants as it possess potent antimicrobial efficacy against S. aureus.

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银纳米粒子对金黄色葡萄球菌的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。

目的：确定纳米银颗粒对金黄色葡萄球菌（S. aureus）的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）：纳米银粒子的抗菌效力是按照临床和实验室标准研究所（CLSI）的标准方法测定的。制备不同浓度的纳米银颗粒，用试管大稀释法计算 MIC。MBC 由杀死 99.9% 初始细菌种群的最低浓度确定。数据采用 SPSS 软件进行方差分析和 Tukey 后检验：结果：银纳米粒子对金黄色葡萄球菌的 MIC 和 MBC 均为 0.625 mg/ml：本研究的结果表明，银纳米粒子在 0.625 毫克/毫升的浓度下对金黄色葡萄球菌具有潜在的杀菌作用。银纳米粒子可用于根管药物、封闭剂和冲洗剂中，因为它对金黄色葡萄球菌具有强大的抗菌功效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomaterial investigations in dentistry

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14 weeks