{"title":"[Molecular mechanisms of entry and egress of herpes simplex virus 1].","authors":"Jun Arii","doi":"10.2222/jsv.69.73","DOIUrl":null,"url":null,"abstract":"Herpes simplex virus (HSV) is a common pathogenic agent causing a variety of diseases in humans such as mucocutaneous and skin diseases, keratitis, and encephalitis. Although antivirals have been developed against HSV, they cannot eradicate the diseases caused by this virus. Thus, to control HSV infection, it is important to elucidate the underlying mechanism of its replication and pathogenesis. HSV encodes more than ten membrane proteins which play important roles in viral entry and egress. This review summarizes the interactions of HSV membrane proteins with the cellular membranes during viral replication.","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"69 1","pages":"73-82"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Uirusu","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2222/jsv.69.73","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Herpes simplex virus (HSV) is a common pathogenic agent causing a variety of diseases in humans such as mucocutaneous and skin diseases, keratitis, and encephalitis. Although antivirals have been developed against HSV, they cannot eradicate the diseases caused by this virus. Thus, to control HSV infection, it is important to elucidate the underlying mechanism of its replication and pathogenesis. HSV encodes more than ten membrane proteins which play important roles in viral entry and egress. This review summarizes the interactions of HSV membrane proteins with the cellular membranes during viral replication.
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