Nail Psoriasis Treatment: Insights into Current Progress and Future Trends.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2020-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2020029259

Pradip Nirbhavane, Gajanand Sharma, Supriya Verma, Rajesh Singh Jadon, Bhupinder Singh, Om Parkash Katare

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引用次数: 3

Abstract

Nail psoriasis is a chronic condition which causes pain and functional impairment; thus, it restricts the activities of daily living and worsens the quality of life. Different chemotherapeutic options are available for treating nail psoriasis such as systemic, intralesional, and topical therapies. However, current chemotherapy suffers from several limitations and to overcome them, new advancements are being made worldwide. Various reports have been published on current progress in the treatment of nail psoriasis such as clinical efficacy studies of novel antipsoriatic agents and novel formulation strategies for current chemotherapy. There are several novel nail formulations for the treatment of nail disorders, particularly onychomycosis, such as vesicular colloidal structure (liposomes, niosomes, transfersomes, ethosomes, etc.) and nonvesicular colloidal structures (nano-emulgel, nanocapsules, thermosensitive gel, etc.) These formulations can also prove beneficial for the treatment of nail psoriasis, and will be heavily explored in the near future. This review provides a brief introduction to the disease, its pathogenesis, and its treatment modalities. The review also throws light onto progress and future perspectives in nail psoriasis treatment.

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指甲牛皮癣治疗:洞察当前进展和未来趋势。

指甲牛皮癣是一种慢性疾病，会导致疼痛和功能损害;因此，它限制了日常生活活动，降低了生活质量。不同的化疗方案可用于治疗指甲银屑病，如全身、局部和局部治疗。然而，目前的化疗有一些局限性，为了克服这些局限性，世界范围内正在取得新的进展。关于甲银屑病治疗的最新进展，如新型抗银屑病药物的临床疗效研究和当前化疗的新配方策略等，已经发表了各种各样的报道。目前有几种新型的指甲制剂用于治疗指甲疾病，特别是甲真菌病，如水疱状胶体结构(脂质体、乳质体、转移体、脂质体等)和非水疱状胶体结构(纳米乳液、纳米胶囊、热敏凝胶等)，这些制剂也可以证明对甲牛皮癣的治疗有益，并将在不久的将来进行大量探索。本文简要介绍了该病的发病机制和治疗方法。本文还对甲癣治疗的进展和未来前景进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.