The Effects of Sensory Enrichment After a Laboratory Stressor on Human Skin Barrier Recovery in a Randomized Trial.

IF 2.9 3区医学 Q2 PSYCHIATRY Psychosomatic Medicine Pub Date : 2020-11-01 DOI:10.1097/PSY.0000000000000858

Mikaela Law, Paul Jarrett, Urs M Nater, Nadine Skoluda, Elizabeth Broadbent

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引用次数: 2

Abstract

Objective: Environmental enrichment (EE) can reduce stress, alter immunity, and speed wound healing in animals. However, it is not known whether these effects translate to humans. This study aimed to investigate whether sensory EE could improve wound healing after a stressor in humans.

Methods: A total of 105 participants underwent a tape-stripping procedure and were then stressed using a laboratory stress paradigm. After this, they were randomized to interact for 30 minutes with one of two possible sensory EE interventions (music as auditory enrichment or a Paro robot as multisensory enrichment) or to a control condition. Skin barrier recovery was measured using transepidermal water loss at baseline, after the stressor, and after the intervention. Stress was measured using self-report, heart rate, blood pressure, and salivary stress-related biological measures. Enjoyment during the intervention was measured by self-report as a possible mediator.

Results: The Paro condition had significantly improved skin barrier recovery (mean [M] = 44%, standard error [SE] = 1.92) compared with the control condition (M = 37% SE = 2.01, F(2,88) = 3.25, p = .043), both with and without controlling for covariates. The music condition did not significantly differ from the other conditions (M = 42%, SE = 1.95, p values > .05). Both objective and subjective stress measures did not significantly differ between conditions. Mediational analysis showed that enjoyment levels during the intervention period significantly mediated the relationship between condition and skin barrier recovery (z = 2.00, p = .046).

Conclusions: Paro, or other companion robots, may be an effective form of enrichment to improve skin barrier recovery in humans after a laboratory stressor, and this effect may be due to enjoyment. Further research with patient groups is required to investigate whether Paro can help heal clinical wounds.

Trial registration: ACTRN12618000953235, registered at https://anzctr.org.au.

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实验室应激源后感觉增强对人体皮肤屏障恢复的影响:一项随机试验。

目的:环境富集(EE)能减轻动物应激，改变机体免疫力，加速伤口愈合。然而，目前尚不清楚这些影响是否会转化为人类。本研究旨在探讨感觉情感表达是否可以改善人类应激源后的伤口愈合。方法:共有105名参与者进行了胶带剥离程序，然后使用实验室应激范式进行应激。在此之后，他们被随机分配到两种可能的感官情感表达干预(音乐作为听觉增强或帕罗机器人作为多感官增强)中的一种或控制条件下进行30分钟的互动。在基线、应激源后和干预后，使用经皮失水测量皮肤屏障恢复情况。通过自我报告、心率、血压和唾液压力相关的生物测量来测量压力。干预期间的快乐是通过自我报告作为可能的中介来衡量的。结果:与对照组(M = 37% SE = 2.01, F(2,88) = 3.25, p = 0.043)相比，无论是否控制协变量，Paro条件均显著改善了皮肤屏障恢复(平均[M] = 44%，标准误差[SE] = 1.92)。音乐组与其他组差异无统计学意义(M = 42%， SE = 1.95, p值> 0.05)。客观和主观压力测量在不同条件下均无显著差异。中介分析显示，干预期间的享受水平显著中介了状态与皮肤屏障恢复之间的关系(z = 2.00, p = 0.046)。结论:Paro或其他伴侣机器人可能是一种有效的强化形式，可以改善人类在实验室应激后皮肤屏障的恢复，这种效果可能是由于享受。需要对患者群体进行进一步的研究，以调查Paro是否有助于临床伤口的愈合。试验注册:ACTRN12618000953235，注册网址:https://anzctr.org.au。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychosomatic Medicine 医学-精神病学

CiteScore

5.10

自引率

0.00%

发文量

258

审稿时长

4-8 weeks

期刊介绍： Psychosomatic Medicine is the official peer-reviewed journal of the American Psychosomatic Society. The journal publishes experimental, clinical, and epidemiological studies on the role of psychological and social factors in the biological and behavioral processes relevant to health and disease. Psychosomatic Medicine is an interdisciplinary peer-reviewed journal devoted to high-quality science on biobehavioral mechanisms, brain-behavior interactions relevant to physical and mental disorders, as well as interventions in clinical and public health settings. Psychosomatic Medicine was founded in 1939 and publishes interdisciplinary research articles relevant to medicine, psychiatry, psychology, and other health-related disciplines. The print journal is published nine times a year; most articles are published online ahead of print. Supplementary issues may contain reports of conferences at which original research was presented in areas relevant to the psychosomatic and behavioral medicine.