Cell fusion and fusogens - an interview with Benjamin Podbilewicz.

IF 1 4区 生物学 Q4 DEVELOPMENTAL BIOLOGY International Journal of Developmental Biology Pub Date : 2021-01-01 DOI:10.1387/ijdb.200220jc
Jesús Chimal-Monroy, Diana Escalante-Alcalde
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Abstract

Cell fusion is a process in which cells unite their membranes and cytoplasm. It is fundamental for sexual reproduction and embryonic development. Among the best-known cell fusion processes during animal development are fertilization, myoblast fusion, osteoclast generation, and vulva formation in Caenorhabditis elegans. Although it is involved in many other functions in unicellular and multicellular organisms, little is known about the mechanisms of cell fusion and the genes that code for the proteins participating in this process. Benjamin Podbilewicz has dedicated many years to understanding the processes and mechanisms of cell fusion. In this interview, he spoke to us about how he began his studies of this process, his contributions to this exciting field, his scientific ties with Ibero-America and his strategies for a well-balanced scientific/personal life.

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细胞融合和融合原——采访本杰明·波德比莱维奇。
细胞融合是细胞结合细胞膜和细胞质的过程。它是有性生殖和胚胎发育的基础。在动物发育过程中,最著名的细胞融合过程包括受精、成肌细胞融合、破骨细胞的产生和秀丽隐杆线虫的外阴形成。虽然它在单细胞和多细胞生物中参与许多其他功能,但对细胞融合的机制和参与这一过程的蛋白质编码基因知之甚少。Benjamin Podbilewicz多年来一直致力于理解细胞融合的过程和机制。在这次采访中,他向我们讲述了他是如何开始研究这一过程的,他对这一令人兴奋的领域的贡献,他与伊比利亚美洲的科学联系,以及他平衡科学与个人生活的策略。
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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
16
审稿时长
2 months
期刊介绍: The International Journal of Developmental Biology (ISSN: 0214- 6282) is an independent, not for profit scholarly journal, published by scientists, for scientists. The journal publishes papers which throw light on our understanding of animal and plant developmental mechanisms in health and disease and, in particular, research which elucidates the developmental principles underlying stem cell properties and cancer. Technical, historical or theoretical approaches also fall within the scope of the journal. Criteria for acceptance include scientific excellence, novelty and quality of presentation of data and illustrations. Advantages of publishing in the journal include: rapid publication; free unlimited color reproduction; no page charges; free publication of online supplementary material; free publication of audio files (MP3 type); one-to-one personalized attention at all stages during the editorial process. An easy online submission facility and an open online access option, by means of which papers can be published without any access restrictions. In keeping with its mission, the journal offers free online subscriptions to academic institutions in developing countries.
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