PEGylated curcumin-loaded nanofibrous mats with controlled burst release through bead knot-on-spring design.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2020-12-01 Epub Date: 2020-10-18 DOI:10.1007/s40204-020-00140-5
Mahdi Saeed, Hamid Mirzadeh, Mojgan Zandi, Jalal Barzin
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引用次数: 3

Abstract

APEGylatedcurcumin (PCU) loaded electrospuns based on poly(ε-caprolactone) (PCL) andpolyvinyl alcohol (PVA) were fabricated for wound dressing applications. The main reason for this wound dressing design is antibacterialactivity enhancement, and wound exudates management. PEGylation increases curcuminsantibacterial properties and PVA can help exudates management. For optimal wound dressing, first, response surface methodology (RSM) was applied to optimize the electrospinning parameters to achieve appropriate nanofibrous mats. Then a three-layer electrospun was designed by considering the water absorbability, PCU release profile as well as antibacterial and biocompatibility of the final wound dressing. The burst release in controlled release systems could be evaluated for prevention of the higher initial drug release and control the effective life time. The PCU release results illustrated that the bead knot plays a positive role in controlling the release profile andby increase in the number of beads per unit area from 3000 to 9000 mm-2,the PCU burst release will be reduced; Also in vitro studies show that optimized three-layer dressing based on PCL/PVA/PCU can support water vapour transmission rate in optimal range and also absorb more than three times exudates in comparison with mono-layerdressing. Antibacterial tests show that the electrospun wound dressing containing 5% PCU exhibits100% antibacterial activityas well as cell viability level within an acceptable range.

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聚乙二醇姜黄素负载的纳米纤维垫与控制爆发释放通过头结弹簧设计。
制备了以聚ε-己内酯(PCL)和聚乙烯醇(PVA)为原料的apeglatedcurcumin (PCU)负载电纺丝用于伤口敷料。这种创面敷料设计的主要原因是抗菌活性的增强和创面渗出物的管理。聚乙二醇化增加了姜黄素的抗菌性能,聚乙烯醇可以帮助管理渗出物。为了优化伤口敷料,首先采用响应面法(RSM)优化静电纺丝参数,以获得合适的纳米纤维垫;然后综合考虑最终创面敷料的吸水性能、PCU释放特性以及抗菌性和生物相容性,设计了三层静电纺材料。控释系统的爆发释放可用于预防药物初始释放过高和控制有效寿命。PCU的释放结果表明,珠结对PCU的释放有积极的控制作用,单位面积珠数从3000 mm-2增加到9000 mm-2, PCU的爆发释放会减少;体外实验也表明,优化后的PCL/PVA/PCU三层敷料能够将水蒸气透过率维持在最佳范围内,并且吸收的渗出物是单层敷料的三倍以上。抗菌测试表明,含有5% PCU的静电纺伤口敷料具有100%的抗菌活性,并且细胞活力水平在可接受的范围内。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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