Sliding mode control for a fractional-order non-linear glucose-insulin system

IF 1.9 4区 生物学 Q4 CELL BIOLOGY IET Systems Biology Pub Date : 2020-09-15 DOI:10.1049/iet-syb.2020.0030
Muhammad Waleed Khan, Muhammad Abid, Abdul Qayyum Khan, Ghulam Mustafa, Muzamil Ali, Asifullah Khan
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引用次数: 10

Abstract

By providing the generalisation of integration and differentiation, and incorporating the memory and hereditary effects, fractional-order modelling has gotten significant attention in the past few years. One of the extensively studied and utilised models to describe the glucose–insulin system of a human body is Bergman's minimal model. This non-linear model comprises of integer-order differential equations. However, comparison with the experimental data shows that the fractional-order version of Bergman's minimal model is a better representative of the glucose–insulin system than its original integer-order model. To design a control law for an artificial pancreas for a diabetic patient using a fractional-order model, different techniques, including feedback linearisation, have been applied in the literature. The authors’ previous work shows that the fractional-order version of Bergman's model describes the glucose–insulin system in a better way than the integer-order model. This study applies the sliding mode control technique and then compares the obtained simulation results with the ones obtained using feedback linearisation.

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分数阶非线性葡萄糖-胰岛素系统的滑模控制
分数阶模型由于具有积分和微分的通用性,并结合了记忆和遗传效应,近年来得到了广泛的关注。一个被广泛研究和使用的模型来描述人体的葡萄糖-胰岛素系统是伯格曼最小模型。该非线性模型由整阶微分方程组成。然而,与实验数据的比较表明,分数阶版本的Bergman最小模型比原来的整数阶模型更能代表葡萄糖-胰岛素系统。为了使用分数阶模型设计糖尿病患者人工胰腺的控制律,文献中应用了不同的技术,包括反馈线性化。作者先前的工作表明,伯格曼模型的分数阶版本比整数阶模型更好地描述了葡萄糖-胰岛素系统。本研究采用滑模控制技术,然后将得到的仿真结果与使用反馈线性化得到的仿真结果进行比较。
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来源期刊
IET Systems Biology
IET Systems Biology 生物-数学与计算生物学
CiteScore
4.20
自引率
4.30%
发文量
17
审稿时长
>12 weeks
期刊介绍: IET Systems Biology covers intra- and inter-cellular dynamics, using systems- and signal-oriented approaches. Papers that analyse genomic data in order to identify variables and basic relationships between them are considered if the results provide a basis for mathematical modelling and simulation of cellular dynamics. Manuscripts on molecular and cell biological studies are encouraged if the aim is a systems approach to dynamic interactions within and between cells. The scope includes the following topics: Genomics, transcriptomics, proteomics, metabolomics, cells, tissue and the physiome; molecular and cellular interaction, gene, cell and protein function; networks and pathways; metabolism and cell signalling; dynamics, regulation and control; systems, signals, and information; experimental data analysis; mathematical modelling, simulation and theoretical analysis; biological modelling, simulation, prediction and control; methodologies, databases, tools and algorithms for modelling and simulation; modelling, analysis and control of biological networks; synthetic biology and bioengineering based on systems biology.
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