Diagnostic Role of Mean-Platelet Volume in Acute Pulmonary Embolism: A Meta-analysis and Systematic Review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2020-10-09 eCollection Date: 2020-01-01 DOI:10.1177/1179548420956365

Cláudia Febra, Ana Macedo

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引用次数: 8

Abstract

Background: Acute pulmonary embolism (PE) is the third most fatal cardiovascular disease. PE is frequently misdiagnosed due to its clinical presentation's heterogeneity and the inexistence of biomarkers for its immediate diagnosis. Mean platelet volume (MPV) has shown a potential role as a biomarker in acute PE. In this analysis, we aimed to systematically compare the MPV in patients with and without definite diagnosis of PE, in emergency departments.

Methods: Embase, PubMed and Medline were searched for relevant publications, in English. The main inclusion criteria were studies which compared MPV in patients with acute PEA versus a control group.

Results: Thirteen studies consisting of a total number of 2428 participants were included. Of the participants included, 1316 were patients with confirmed acute PE, and 1112 were assigned to the control group. MPV was significantly higher in patients with acute PE than in controls (RR: 0.84, 95% CI: 0.76 - 0.92; P < .00001). There was a significant heterogeneity in the data.

Conclusions: This analysis showed higher MPV to be associated with acute PE immediate diagnosis. These data show promise for the use of MPV as a readily available biomarker for the diagnosis of acute PE at the emergency department.

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平均血小板体积在急性肺栓塞中的诊断作用:荟萃分析和系统评价。

背景:急性肺栓塞(PE)是第三大致命性心血管疾病。由于其临床表现的异质性和缺乏可立即诊断的生物标志物，PE经常被误诊。平均血小板体积(MPV)已显示出作为急性PE生物标志物的潜在作用。在本分析中，我们旨在系统地比较急诊科确诊和未确诊PE患者的MPV。方法:检索Embase、PubMed和Medline相关英文文献。主要纳入标准是比较急性PEA患者与对照组的MPV的研究。结果:纳入13项研究，共纳入2428名受试者。在纳入的参与者中，1316名确诊为急性PE的患者，1112名被分配到对照组。急性PE患者的MPV明显高于对照组(RR: 0.84, 95% CI: 0.76 - 0.92;P < 0.001)。数据中存在显著的异质性。结论:该分析显示较高的MPV与急性PE的即时诊断相关。这些数据表明，MPV有望成为急诊科诊断急性PE的一种现成的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.