A Review of Neuro-Ophthalmological Manifestations of Human Coronavirus Infection.

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2020-10-30 eCollection Date: 2020-01-01 DOI:10.2147/EB.S268828

Maria Elisa Luís, Diogo Hipólito-Fernandes, Catarina Mota, Diogo Maleita, Catarina Xavier, Tiago Maio, João Paulo Cunha, Joana Tavares Ferreira

{"title":"A Review of Neuro-Ophthalmological Manifestations of Human Coronavirus Infection.","authors":"Maria Elisa Luís, Diogo Hipólito-Fernandes, Catarina Mota, Diogo Maleita, Catarina Xavier, Tiago Maio, João Paulo Cunha, Joana Tavares Ferreira","doi":"10.2147/EB.S268828","DOIUrl":null,"url":null,"abstract":"Introduction: Human coronavirus (HCoVs) are a group of viruses with recognized neurotropic and neuroinvasive capabilities. The reports on the neurological and ocular findings are increasing day after day and several central and peripheral neurological manifestations are already described. However, none specifically describes the neuro-ophthalmological manifestation of HCoVs. This is the first article specifically reviewing neuro-ophthalmological manifestations of HCoVs infection.Methods: PubMed and Google Scholar databases were searched using the keywords: coronaviridae, coronavirus, COVID-19, SARS-CoV-2, SARS-CoV-1, MERS, ocular, ophthalmology, ophthalmological, neuro-ophthalmology, neurological, manifestations. A manual search through the reference lists of relevant articles was also performed. There were no restrictions concerning language or study type and publications not yet printed but available online were considered.Results: Coronavirus eye involvement is not frequent and includes mostly a typical viral follicular conjunctivitis. Recently, retinal anatomical alterations were described using optic coherence tomography. Neuro-ophthalmological symptoms and signs can appear isolated or associated with neurological syndromes. The manifestations include headache, ocular pain, visual impairment, diplopia, and cranial nerve palsies secondary to Miller Fisher syndrome, Guillain-Barré syndrome, or encephalitis, and nystagmus.Conclusion: Neurological and neuro-ophthalmological syndromes, symptoms, and signs should not be neglected and a complete ophthalmological examination of these patients should be performed to fully describe ocular manifestations related to HCoVs. We believe that major ocular and neuro-ophthalmological manifestations reports lack due to safety issues concerning detailed ophthalmological examination; on the other hand, in a large number of cases, the presence of life-threatening coronavirus disease hinders ocular examination and ophthalmologist's visit to the intensive care unit.","PeriodicalId":51844,"journal":{"name":"Eye and Brain","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/EB.S268828","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eye and Brain","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/EB.S268828","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 2

Abstract

Introduction: Human coronavirus (HCoVs) are a group of viruses with recognized neurotropic and neuroinvasive capabilities. The reports on the neurological and ocular findings are increasing day after day and several central and peripheral neurological manifestations are already described. However, none specifically describes the neuro-ophthalmological manifestation of HCoVs. This is the first article specifically reviewing neuro-ophthalmological manifestations of HCoVs infection.

Methods: PubMed and Google Scholar databases were searched using the keywords: coronaviridae, coronavirus, COVID-19, SARS-CoV-2, SARS-CoV-1, MERS, ocular, ophthalmology, ophthalmological, neuro-ophthalmology, neurological, manifestations. A manual search through the reference lists of relevant articles was also performed. There were no restrictions concerning language or study type and publications not yet printed but available online were considered.

Results: Coronavirus eye involvement is not frequent and includes mostly a typical viral follicular conjunctivitis. Recently, retinal anatomical alterations were described using optic coherence tomography. Neuro-ophthalmological symptoms and signs can appear isolated or associated with neurological syndromes. The manifestations include headache, ocular pain, visual impairment, diplopia, and cranial nerve palsies secondary to Miller Fisher syndrome, Guillain-Barré syndrome, or encephalitis, and nystagmus.

Conclusion: Neurological and neuro-ophthalmological syndromes, symptoms, and signs should not be neglected and a complete ophthalmological examination of these patients should be performed to fully describe ocular manifestations related to HCoVs. We believe that major ocular and neuro-ophthalmological manifestations reports lack due to safety issues concerning detailed ophthalmological examination; on the other hand, in a large number of cases, the presence of life-threatening coronavirus disease hinders ocular examination and ophthalmologist's visit to the intensive care unit.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

人冠状病毒感染的神经眼科表现综述

人类冠状病毒(HCoVs)是一类公认的嗜神经性和侵袭性病毒。关于神经学和眼学发现的报告日复一日地增加，并且已经描述了几种中枢和周围神经学表现。然而，没有一个专门描述hcov的神经-眼科表现。这是第一篇专门回顾hcov感染的神经-眼科表现的文章。方法:以冠状病毒科、冠状病毒、COVID-19、SARS-CoV-2、SARS-CoV-1、MERS、眼科、眼科、神经眼科、神经学、表现为关键词检索PubMed和Google Scholar数据库。还对相关文章的参考书目进行了人工检索。对语言或研究类型没有限制，并考虑了尚未印刷但可在网上获得的出版物。结果:冠状病毒累及眼部并不常见，主要包括典型的病毒性滤泡性结膜炎。最近，视网膜解剖改变被描述使用光学相干断层扫描。神经眼科症状和体征可单独出现或与神经系统综合征相关。其表现包括头痛、眼痛、视力损害、复视、继发于米勒-费雪综合征、格林-巴-罗综合征或脑炎和眼球震颤的脑神经麻痹。结论:不应忽视神经和神经眼科综合征、症状和体征，应对这些患者进行完整的眼科检查，以充分描述与hcov相关的眼部表现。我们认为，由于详细眼科检查的安全性问题，主要的眼部和神经眼科表现报告不足;另一方面，在大量病例中，危及生命的冠状病毒的存在阻碍了眼科检查和眼科医生前往重症监护病房。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Eye and Brain OPHTHALMOLOGY-

CiteScore

7.90

自引率

2.30%

发文量

审稿时长

16 weeks

期刊介绍： Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.