Common Issues Among Asthma, Epilepsy, and Schizophrenia: From Inflammation to Ca²⁺/cAMP Signalling.

Q2 Medicine Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2021-01-01 DOI:10.2174/1871523019999201110192029

Leandro Bueno Bergantin

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引用次数: 1

Abstract

Background: A large amount of evidence has described that asthma may be associated with a high epilepsy risk, and epilepsy may be linked with high asthma risk, especially among children and individuals in their 30s. Curiously, asthma has also been associated with an increased risk for schizophrenia. Most interestingly, a bidirectional link between schizophrenia and epilepsy has also been established and has been of interest for many years.

Objective: Bearing in mind the experience of our group in the field of Ca²⁺/cAMP signalling pathways, this article discussed, beyond inflammation, the role of these signalling pathways in this link among epilepsy, asthma, and schizophrenia.

Methods: Publications involving these signalling pathways, asthma, epilepsy, and schizophrenia (alone or combined) were collected by searching PubMed and EMBASE.

Results and conclusion: There is a clear relationship between Ca²⁺ signalling, e.g. increased Ca²⁺ signals and inflammatory responses. In addition to Ca²⁺, cAMP regulates pro- and anti-inflammatory responses. Then, beyond inflammation, the comprehension of the link among epilepsy, asthma, and schizophrenia could improve the drug therapy.

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哮喘、癫痫和精神分裂症的共同问题:从炎症到Ca2+/cAMP信号传导。

背景:大量证据表明，哮喘可能与高癫痫风险相关，癫痫可能与高哮喘风险相关，特别是在儿童和30多岁的个体中。奇怪的是，哮喘还与精神分裂症的风险增加有关。最有趣的是，精神分裂症和癫痫之间的双向联系也已确立，并已引起人们多年的兴趣。目的:考虑到我们小组在Ca2+/cAMP信号通路领域的经验，本文讨论了除炎症外，这些信号通路在癫痫、哮喘和精神分裂症之间的联系中的作用。方法:通过检索PubMed和EMBASE收集涉及这些信号通路、哮喘、癫痫和精神分裂症(单独或联合)的出版物。结果和结论:Ca2+信号与炎症反应之间存在明显的关系，如Ca2+信号的增加。除Ca2+外，cAMP还调节促炎和抗炎反应。然后，除了炎症之外，对癫痫、哮喘和精神分裂症之间联系的理解可以改善药物治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

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期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.