Loss of Annexin A10 Expression Is Associated with Poor Prognosis in Early Gastric Cancer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2020-10-29 Epub Date: 2020-09-24 DOI:10.1267/ahc.20-00014

Akira Ishikawa, Kazuya Kuraoka, Junichi Zaitsu, Akihisa Saito, Toshio Kuwai, Takahisa Suzuki, Hirotaka Tashiro, Kiyomi Taniyama, Wataru Yasui

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Abstract

Gastric cancer (GC) is the third most common cause of cancer-related mortality. The diagnosis and treatment of early GC is a crucial strategy for prognostic improvement of GC. Annexin A10 (ANXA10), a calcium-/phospholipid-binding protein, is a member of the annexin family. The significance of ANXA10 expression in early GC remains unclear. This is the first report to investigate ANXA10 expression in early GC. We performed immunohistochemistry to evaluate ANXA10 expression in early GC, and the correlation between ANXA10 and clinicopathological factors. The loss of ANXA10 expression was detected in 63 (61.2%) of 103 early GC cases and significantly correlated with poor overall survival in patients. Sex, pT stage, pN stage, histology, and ANXA10 expression were associated with poor survival. Sex, histology, and ANXA10 expression were determined as independent predictors of survival in early GC patients. ANXA10 immunostaining could be a new decision-making biomarker in GC.

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早期胃癌患者Annexin A10表达缺失与预后不良有关

胃癌（GC）是导致癌症相关死亡的第三大常见病因。早期胃癌的诊断和治疗是改善胃癌预后的关键策略。附件蛋白 A10（ANXA10）是一种钙/磷脂结合蛋白，是附件蛋白家族的成员。ANXA10的表达在早期GC中的意义尚不清楚。这是第一份研究 ANXA10 在早期 GC 中表达的报告。我们采用免疫组化方法评估了ANXA10在早期GC中的表达，以及ANXA10与临床病理因素之间的相关性。在103例早期GC病例中，有63例（61.2%）检测到ANXA10表达缺失，且ANXA10表达缺失与患者的总生存率显著相关。性别、pT分期、pN分期、组织学和ANXA10表达与生存率低有关。性别、组织学和ANXA10表达被确定为早期GC患者生存率的独立预测因素。ANXA10免疫染色可能是GC新的决策生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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