Nonadherence to Antiepileptic Medications and Its Determinants among Epileptic Patients at the University of Gondar Referral Hospital, Gondar, Ethiopia, 2019: An Institutional-Based Cross-Sectional Study.

IF 1.7 Q4 NEUROSCIENCES Neurology Research International Pub Date : 2020-10-28 eCollection Date: 2020-01-01 DOI:10.1155/2020/8886828

Misganaw Tilahun, Netsanet Habte, Kenean Mekonnen, Mengesha Srahbzu, Daniel Ayelegne

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引用次数: 10

Abstract

Introduction: Nonadherence to antiepileptic medication is the extent of a patient's passive failure to follow the prescribed therapeutic regimen. The prevalence and impact of nonadherence to antiepileptic medication are high globally. The main purpose of this study was to assess nonadherence to antiepileptic medications and its associated factors among epileptic patients at the University of Gondar Referral Hospital, Gondar, Ethiopia, 2019.

Methods: An institutional-based cross-sectional study was conducted among 365 epileptic patients at the University of Gondar Referral Hospital, who were selected by a systematic random sampling technique. Data were collected by face to face interviews using a structured pretested questionnaire. Data were entered into EPI Info version 7 and then exported to SPSS version 22 for analysis. The data were described by descriptive statistics. Binary logistic regression analysis was used as a model, and variables with a p value of less than 0.05 were considered as statistically significant with nonadherence to antiepileptic medications.

Results: A total of 356 epileptic patients participated in the study yielding a response rate of 97.5%. The overall prevalence of nonadherence to antiepileptic medications among epileptic patients attending at the University of Gondar Referral Hospital was 38.5% (95% CI: 33.1-43.8). Divorced and/or widowed marital status (AOR: 3.38 (95% CI: 1.54, 7.44)), treatment duration of 3-5 years (AOR = 3.58 (95% CI: 1.38, 9.29)), treatment duration of 5 and above years (AOR: 3.49 (95% CI: 1.53, 7.95)), comorbidity (AOR: 2.42 (95% CI: 1.08, 5.43)), side effects of antiepileptic medications (AOR: 3.36 (95% CI: 1.67, 6.74)), absence of health information (AOR: 1.98 (95% CI: 1.11, 3.52)), epilepsy-related stigma (AOR: 2.81 (95% CI: 1.57, 5.02)), and negative attitude towards antiepileptic medications (AOR: 2.46 (95% CI: 1.36, 4.45)) were significantly associated with nonadherence to antiepileptic medications.

Conclusions: Prevalence of nonadherence to antiepileptic medications among epileptic patients at the University of Gondar Referral Hospital was found to be high. Hence, giving health information about epilepsy and its management will help to reduce antiepileptic medications' nonadherence.

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2019年埃塞俄比亚贡达尔大学转诊医院癫痫患者抗癫痫药物不依从及其决定因素:一项基于机构的横断面研究

简介:抗癫痫药物的不依从性是指患者被动失败的程度，不能遵循规定的治疗方案。抗癫痫药物不依从性的患病率和影响在全球都很高。本研究的主要目的是评估2019年埃塞俄比亚贡达尔大学转诊医院癫痫患者抗癫痫药物依从性及其相关因素。方法:采用系统随机抽样方法，对贡达尔大学转诊医院365例癫痫患者进行机构横断面研究。数据通过面对面访谈收集，采用结构化的预测问卷。数据输入EPI Info version 7，然后导出到SPSS version 22进行分析。数据用描述性统计进行描述。采用二元logistic回归分析作为模型，p值小于0.05的变量认为抗癫痫药物不依从具有统计学意义。结果:共有356例癫痫患者参与研究，有效率为97.5%。在贡达尔大学转诊医院就诊的癫痫患者中，抗癫痫药物不依从的总体患病率为38.5% (95% CI: 33.1-43.8)。离婚和/或丧偶的婚姻状况(AOR: 3.38 (95% CI: 1.54, 7.44))，治疗时间3-5年(AOR = 3.58 (95% CI: 1.38, 9.29))，治疗时间5年及以上(AOR: 3.49 (95% CI: 1.53, 7.95))，共病(AOR: 2.42 (95% CI: 1.08, 5.43))，抗癫痫药物的副作用(AOR: 3.36 (95% CI: 1.67, 6.74))，缺乏健康信息(AOR: 1.98 (95% CI: 1.11, 3.52))，癫痫相关的病耻感(AOR: 2.81 (95% CI: 2.81):1.57, 5.02))，以及对抗癫痫药物的消极态度(AOR: 2.46 (95% CI: 1.36, 4.45))与抗癫痫药物不依从性显著相关。结论:冈达尔大学转诊医院癫痫患者抗癫痫药物不依从率较高。因此，提供有关癫痫及其管理的健康信息将有助于减少抗癫痫药物的不依从性。

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来源期刊

Neurology Research International NEUROSCIENCES-

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Neurology Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on diseases of the nervous system, as well as normal neurological functioning. The journal will consider basic, translational, and clinical research, including animal models and clinical trials.