The Model of PPARγ-Downregulated Signaling in Psoriasis.

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL PPAR Research Pub Date : 2020-10-09 eCollection Date: 2020-01-01 DOI:10.1155/2020/6529057
Vladimir Sobolev, Anastasia Nesterova, Anna Soboleva, Evgenia Dvoriankova, Anastas Piruzyan, Dzerassa Mildzikhova, Irina Korsunskaya, Oxana Svitich
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引用次数: 9

Abstract

Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of PPARγ-downregulated signaling in psoriasis. We hypothesize that the expression of IL17, STAT3, FOXP3, and RORC and FOSL1 genes in psoriatic skin is correlated with the level of PPARγ expression, and they belong to the same signaling pathway that regulates the development of psoriasis lesion.

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银屑病ppar γ-下调信号通路模型的研究。
交叉信号通路中基因的相互作用,以及环境的影响,是银屑病发展所必需的。过氧化物酶体增殖物激活受体γ (PPARγ)是一种核受体和转录因子,可抑制许多促炎基因的表达。我们验证了低水平PPARγ表达促进银屑病病变发展的假设。我们将实验结果与网络功能分析相结合,重建银屑病中ppar γ下调信号通路的模型。我们推测银屑病皮肤中IL17、STAT3、FOXP3、RORC和FOSL1基因的表达与PPARγ表达水平相关,它们属于调节银屑病病变发展的同一信号通路。
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来源期刊
PPAR Research
PPAR Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.20
自引率
3.40%
发文量
17
审稿时长
12 months
期刊介绍: PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.
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