Vladimir Sobolev, Anastasia Nesterova, Anna Soboleva, Evgenia Dvoriankova, Anastas Piruzyan, Dzerassa Mildzikhova, Irina Korsunskaya, Oxana Svitich
{"title":"The Model of <i>PPARγ</i>-Downregulated Signaling in Psoriasis.","authors":"Vladimir Sobolev, Anastasia Nesterova, Anna Soboleva, Evgenia Dvoriankova, Anastas Piruzyan, Dzerassa Mildzikhova, Irina Korsunskaya, Oxana Svitich","doi":"10.1155/2020/6529057","DOIUrl":null,"url":null,"abstract":"<p><p>Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (<i>PPARγ</i>) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of <i>PPARγ</i> expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of <i>PPARγ</i>-downregulated signaling in psoriasis. We hypothesize that the expression of <i>IL17</i>, <i>STAT3</i>, <i>FOXP3</i>, and <i>RORC</i> and <i>FOSL1</i> genes in psoriatic skin is correlated with the level of <i>PPARγ</i> expression, and they belong to the same signaling pathway that regulates the development of psoriasis lesion.</p>","PeriodicalId":20439,"journal":{"name":"PPAR Research","volume":"2020 ","pages":"6529057"},"PeriodicalIF":3.5000,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6529057","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PPAR Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2020/6529057","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 9
Abstract
Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of PPARγ-downregulated signaling in psoriasis. We hypothesize that the expression of IL17, STAT3, FOXP3, and RORC and FOSL1 genes in psoriatic skin is correlated with the level of PPARγ expression, and they belong to the same signaling pathway that regulates the development of psoriasis lesion.
期刊介绍:
PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.