Impact of comorbid asthma on severity of coronavirus disease (COVID-19).

IF 4.7 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2020-12-11 DOI:10.1038/s41598-020-77791-8

Sang Chul Lee, Kang Ju Son, Chang Hoon Han, Ji Ye Jung, Seon Cheol Park

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Abstract

The severity of the coronavirus disease (COVID-19) is associated with various comorbidities. However, no studies have yet demonstrated the potential risk of respiratory failure and mortality in COVID-19 patients with pre-existing asthma. We selected 7272 adult COVID-19 patients from the Korean Health Insurance Review and Assessment COVID-19 database for this nationwide retrospective cohort study. Among these, 686 patients with asthma were assessed by their severities and evaluated by the clinical outcome of COVID-19 compared to patients without asthma. Of 7272 adult COVID-19 patients, 686 with asthma and 6586 without asthma were compared. Asthma was not a significant risk factor for respiratory failure or mortality among all COVID-19 patients (odds ratio [OR] = 0.99, P = 0.997 and OR = 1.06, P = 0.759) after adjusting for age, sex, and the Charlson comorbidity score. However, a history of acute exacerbation (OR = 2.63, P = 0.043) was significant risk factors for death among COVID-19 patients with asthma. Asthma is not a risk factor for poor prognosis of COVID-19. However, asthma patients who had any experience of acute exacerbation in the previous year before COVID-19 showed higher COVID-19-related mortality, especially in case of old age and male sex.

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合并哮喘对冠状病毒疾病（COVID-19）严重程度的影响。

冠状病毒疾病（COVID-19）的严重程度与各种合并症有关。然而，尚未有研究证明 COVID-19 患者在原有哮喘的情况下可能存在呼吸衰竭和死亡的风险。我们从韩国健康保险审查和评估 COVID-19 数据库中选取了 7272 名 COVID-19 成年患者，进行了这项全国性的回顾性队列研究。其中，686 名哮喘患者接受了严重程度评估，并通过 COVID-19 的临床结果与非哮喘患者进行了比较。在 7272 名 COVID-19 成人患者中，有 686 名哮喘患者和 6586 名无哮喘患者进行了比较。在对年龄、性别和 Charlson 合并症评分进行调整后，哮喘并不是所有 COVID-19 患者呼吸衰竭或死亡的重要风险因素（几率比 [OR] = 0.99，P = 0.997 和 OR = 1.06，P = 0.759）。然而，急性加重病史（OR = 2.63，P = 0.043）是 COVID-19 哮喘患者死亡的重要风险因素。哮喘并不是 COVID-19 预后不良的危险因素。然而，在 COVID-19 之前一年曾经历过急性加重的哮喘患者与 COVID-19 相关的死亡率较高，尤其是老年和男性患者。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico

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