Astaxanthin protects cognitive function of vascular dementia.

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES Behavioral and Brain Functions Pub Date : 2020-11-18 DOI:10.1186/s12993-020-00172-8
Ningwei Zhu, Xiao Liang, Ming Zhang, Xiaolan Yin, Hui Yang, Yajun Zhi, Guizhen Ying, Jialing Zou, Lei Chen, Xiaokun Yao, Hongwei Li
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引用次数: 12

Abstract

Objective: The purpose of this study was to evaluate the effect of astaxanthin (AST) on cognition function, inflammatory response and oxidative stress in vascular dementia (VD) mice.

Method: VD mice model was established by left unilateral common carotid arteries occlusion (LUCCAO). Following LUCCAO, AST was intragastrically administered for 30 days. Object recognition test and morris water maze test were used to evaluate cognitive function. Hematoxylin and eosin staining was performed to observe the hippocampal neuron structure. Enzyme-linked immunosorbent assay kit and bicinchoninic acid kit were respectively adopted to measure IL-1β and IL-4 protein expression and superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in hippocampus and prefrontal cortex.

Results: AST improved the discrimination ability of VD mice. The escape latency and path length of VD mice treated with AST were dramatically reduced. Besides, AST 200 mg/kg enhanced crossing platform time and the number of times crossing the platform quadrant, and alleviated the morphological impairment in VD mice. Moreover, we found that AST inhibited IL-1β expression and MDA content, whereas promoted IL-4 expression and SOD activity in a dose-dependent manner.

Conclusion: AST could improve cognitive impairment and hippocampal neurons in VD mice, which may be related to suppression of inflammatory response and oxidative stress.

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虾青素保护血管性痴呆的认知功能。
目的:探讨虾青素(AST)对血管性痴呆(VD)小鼠认知功能、炎症反应和氧化应激的影响。方法:建立左单侧颈总动脉闭塞(LUCCAO)小鼠VD模型。LUCCAO后,AST灌胃30 d。采用物体识别测验和morris水迷宫测验评价认知功能。采用苏木精和伊红染色观察海马神经元结构。采用酶联免疫吸附测定试剂盒和比辛胆酸测定试剂盒分别测定海马和前额叶皮层组织中IL-1β、IL-4蛋白表达及超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果:AST提高了VD小鼠的识别能力。AST治疗后VD小鼠的逃逸潜伏期和路径长度明显缩短。此外,AST 200 mg/kg可增加VD小鼠穿越平台的时间和穿越平台象限的次数,并可减轻形态学损伤。此外,我们发现AST抑制IL-1β表达和MDA含量,而促进IL-4表达和SOD活性呈剂量依赖性。结论:AST可改善VD小鼠的认知功能障碍和海马神经元,其机制可能与抑制炎症反应和氧化应激有关。
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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