{"title":"Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review.","authors":"Eleonora Nucera, Riccardo Inchingolo, Manuela Ferraironi, Arianna Aruanno, Raffaella Chini, Angela Rizzi","doi":"10.12932/AP-250320-0793","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.</p><p><strong>Objective: </strong>To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.</p><p><strong>Methods: </strong>Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.</p><p><strong>Results: </strong>We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.</p><p><strong>Conclusions: </strong>BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"171-175"},"PeriodicalIF":2.3000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific journal of allergy and immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12932/AP-250320-0793","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.
Objective: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.
Methods: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.
Results: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.
Conclusions: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.
期刊介绍：
The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747
APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume.
APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand.
The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.
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