Tongue lesion due to Cryptococcus neoformans as the first finding in an HIV-positive patient

IF 1.5 4区生物学 Q4 MYCOLOGY Revista Iberoamericana De Micologia Pub Date : 2021-01-01 DOI:10.1016/j.riam.2020.10.003

Gabriela María Santiso , Fernando Messina , Andrea Gallo , Emmanuel Marín , Roxana Depardo , Alicia Arechavala , Laura Walker , Ricardo Negroni , María Mercedes Romero

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引用次数: 3

Abstract

Background

Cryptococcosis is a severe universally distributed mycosis which mainly affects immunocompromised hosts. This mycosis is caused by yeasts of two species complex of the genus Cryptococcus: Cryptococcus neoformans and Cryptococcus gattii. Meningeal cryptococcosis is the most frequent clinical presentation of this disseminated mycosis. The oral mucosa involvement is extremely unusual.

Case report

We present a case of cryptococcosis with an unusual clinical form. The patient was assisted because she had an ulcerated lesion on the lingual mucosa. Encapsulated yeasts compatible with Cryptococcus were found in microscopic exams of wet preparations from lingual ulcer clinical samples obtained for cytodiagnosis and mycological studies. Cryptococcus neoformans (C. neoformans var. grubii VNI) was isolated in culture. This patient did not know her condition of HIV seropositive before the appearance of the tongue lesion.

Conclusions

The involvement of the oral mucosa is uncommon in this fungal infection, but is important to include it in the differential diagnosis in HIV positive patients.

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在hiv阳性患者中首次发现由新型隐球菌引起的舌损

隐球菌病是一种严重的普遍分布的真菌病，主要影响免疫功能低下的宿主。这种真菌病是由两种复杂的隐球菌属酵母引起的:新生隐球菌和加蒂隐球菌。脑膜隐球菌病是这种弥散性真菌病最常见的临床表现。口腔黏膜受累是非常罕见的。病例报告我们报告一例隐球菌病与一个不寻常的临床形式。该病人因舌黏膜溃疡而接受辅助治疗。在用于细胞诊断和真菌学研究的舌溃疡临床样本的湿制剂的显微镜检查中发现了与隐球菌相容的封装酵母。培养分离到新生隐球菌(C. neoformans var. grubii VNI)。该患者在舌头出现病变前并不知道自己的HIV血清阳性情况。结论累及口腔黏膜的真菌感染在HIV阳性患者中并不常见，但在鉴别诊断中应将其纳入考虑范围。

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来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.