COVID 19 with neurological symptoms, rhabdomyolysis and brain death: a case report.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2020-12-15 eCollection Date: 2020-01-01
Amir Aria, Khatereh Forouharnejad, Mozhgan Mortazavi, Ashkan Omidi, Mozhde Askari, Keyvan Ghadimi, Nazlisadat Mashinchi-Asl
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Abstract

Background: In the worldwide, there are the pandemic of the virus coronavirus disease 2019 (COVID-19) and there is no approved treatment for this disease.

Case presentation: This study reported a new case with COVID 19 with neurological symptoms such as headache and loss of consciousness without any symptoms and imaging of COVID 19 in admission but RT-PCR COVID 19 of patient was positive and during hospitalization patient had increasing cerebrospinal fluid (CSF) volume in sub-arachnoid space, micro-hemorrhaging in basal ganglia and down ward cerebellar tonsile herniation in the brain imaging, also there were rhabdomyolysis and thrombotic thrombocytopenic purpura in the lab data. Finally, based on abnormal electroencephalogram (EEG), brain death was diagnosed for patient in end of hospitalization. In the 8th of admission day, the patients died after cardiovascular arrest.

Conclusion: The COVID 19 can be associated with different symptoms such as neurological complication and brain death was unusual complication in COVID19.

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新冠肺炎合并神经系统症状、横纹肌溶解和脑死亡1例报告
背景:在全球范围内,新型冠状病毒病2019 (COVID-19)正在大流行,目前尚无批准的治疗方法。案例介绍:本研究报告1例新发COVID - 19患者,入院时无新冠肺炎症状和影像学,但患者RT-PCR检测COVID - 19阳性,住院期间脑影像学显示蛛网膜下腔脑脊液体积增加,基底节区微出血,小脑扁桃体向下突出。在实验室数据中也有横纹肌溶解和血栓性血小板减少性紫癜。最后根据异常脑电图(EEG)诊断患者在住院末期脑死亡。入院第8天,患者因心血管骤停死亡。结论:新冠肺炎可伴有不同症状,如神经系统并发症,脑死亡是新冠肺炎的罕见并发症。
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