PPARα Agonist WY-14643 Relieves Neuropathic Pain through SIRT1-Mediated Deacetylation of NF-κB.

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL PPAR Research Pub Date : 2020-12-14 eCollection Date: 2020-01-01 DOI:10.1155/2020/6661642
Wanshun Wen, Jinlin Wang, Biyu Zhang, Jun Wang
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引用次数: 5

Abstract

Inflammation caused by neuropathy contributes to the development of neuropathic pain (NP), but the exact mechanism still needs to be understood. Peroxisome proliferator-activated receptor α (PPARα), an important inflammation regulator, might participate in the inflammation in NP. To explore the role of PPARα in NP, the effects of PPARα agonist WY-14643 on chronic constriction injury (CCI) rats were evaluated. The results showed that WY-14643 stimulation could decrease inflammation and relieve neuropathic pain, which was relative with the activation of PPARα. In addition, we also found that the SIRT1/NF-κB pathway was involved in the WY-14643-induced anti-inflammation in NP, and activation of PPARα increased SIRT1 expression, thus reducing the proinflammatory function of NF-κB. These data suggested that WY-14643 might serve as an inflammation mediator, which may be a potential therapy option for NP.

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PPARα激动剂WY-14643通过sirt1介导的NF-κB去乙酰化缓解神经性疼痛。
神经病变引起的炎症有助于神经性疼痛(NP)的发展,但其确切机制尚不清楚。过氧化物酶体增殖物激活受体α (PPARα)是一种重要的炎症调节剂,可能参与NP的炎症反应。为了探讨ppara α在NP中的作用,我们观察了ppara α激动剂WY-14643对慢性收缩性损伤(CCI)大鼠的作用。结果表明,WY-14643刺激能减轻炎症反应,减轻神经性疼痛,其作用与PPARα的激活有关。此外,我们还发现SIRT1/NF-κB通路参与wy -14643诱导的NP抗炎,激活PPARα增加SIRT1表达,从而降低NF-κB的促炎功能。这些数据提示WY-14643可能作为炎症介质,可能是NP的潜在治疗选择。
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来源期刊
PPAR Research
PPAR Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.20
自引率
3.40%
发文量
17
审稿时长
12 months
期刊介绍: PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.
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