Neutrophil-Lymphocyte Ratio as a Prognostic Marker in Adrenocortical Carcinoma.

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine Research Pub Date : 2021-02-01 Epub Date: 2021-01-08 DOI:10.1080/07435800.2020.1870234

Mirsala Solak, Ivana Kraljević, Karin Zibar Tomšić, Marko Kaštelan, Luka Kakarigi, Darko Kaštelan

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引用次数: 6

Abstract

Purpose: The purpose of the present study was to analyze the impact of the neutrophil-lymphocyte ratio (NLR) on the long-term outcomes of patients with adrenocortical carcinoma (ACC).

Methods: This retrospective, single-institution study included 48 patients with the diagnosis of ACC. The primary outcomes of the study were differences in overall survival (OS) and disease-specific survival (DSS) with respect to the NLR level.

Results: Patients with ENSAT stage IV had higher levels of NLR compared to those with ENSAT stage I-III (5.7 (1.6-12.5) vs 3.3 (1.3-11); p = .01). A higher NLR was also observed among patients with cortisol-secreting tumors (4.6 (1.7-12.5) vs 2.8 (1.3-10.3); p = .003) and those with Ki-67 index >10% (4.3 (1.3-12.5) vs 2.6 (1.6-11.0); p = .005). With respect to survival, the univariate analysis revealed worse ACC-related survival (p = .02) and OS (p = .004) in patients with NLR >3.9 than in those with NLR ≤3.9. In addition, patients with NLR >3.9 had a higher Weiss score (p = .046), a higher Ki-67 index (p = .006) and a higher disease stage (p = .01) compared to patients with NLR ≤3.9. No differences between the groups were observed regarding excess glucocorticoid secretion.

Conclusion: The study demonstrated that a higher NLR level in ACC patients was associated with unfavorable outcomes in terms of DSS and OS. These results indicate that NLR might be used as an additional marker in ACC risk stratification and identification of patients with the most adverse prognosis.

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中性粒细胞-淋巴细胞比值作为肾上腺皮质癌的预后指标。

目的:本研究的目的是分析中性粒细胞-淋巴细胞比率(NLR)对肾上腺皮质癌(ACC)患者长期预后的影响。方法:本回顾性、单机构研究纳入48例诊断为ACC的患者。研究的主要结果是总生存期(OS)和疾病特异性生存期(DSS)相对于NLR水平的差异。结果:IV期患者的NLR水平高于I-III期患者(5.7 (1.6-12.5)vs 3.3 (1.3-11);P = 0.01)。皮质醇分泌肿瘤患者的NLR也较高(4.6 (1.7-12.5)vs 2.8 (1.3-10.3);p = 0.003)和Ki-67指数>10%的患者(4.3 (1.3-12.5)vs 2.6 (1.6-11.0);P = .005)。在生存方面，单因素分析显示，NLR >3.9的患者比NLR≤3.9的患者acc相关生存(p = 0.02)和OS (p = 0.004)更差。此外，NLR >3.9的患者比NLR≤3.9的患者有更高的Weiss评分(p = 0.046)、Ki-67指数(p = 0.006)和更高的疾病分期(p = 0.01)。两组之间在糖皮质激素分泌过量方面没有差异。结论:本研究表明ACC患者NLR水平升高与DSS和OS的不良结局相关。这些结果表明，NLR可作为ACC风险分层和鉴别预后最不良患者的附加标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.

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