A case with Crohn's disease-associated spondyloarthritis exhibiting enhanced pro-inflammatory cytokine responses to Toll-like receptor ligands.

IF 2.3 4区医学 Q3 ALLERGY Asian Pacific journal of allergy and immunology Pub Date : 2024-12-01 DOI:10.12932/AP-291220-1025

Hajime Honjo, Tomohiro Watanabe, Natsuki Okai, Masashi Kono, Ken Kamata, Kosuke Minaga, Yoriaki Komeda, Shigeyoshi Tsuji, Masatoshi Kudo

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Abstract

Background: Despite the high incidence of spondyloarthritis (SpA) as an extra-intestinal manifestation of Crohn's disease (CD), the immunopathogenesis of CD-associated SpA remains largely unknown.

Objective: We tried to explore molecular mechanisms accounting for the development of CD-associated SpA in a patient successfully treated with infliximab.

Methods: Peripheral blood mononuclear cells (PBMCs) before infliximab treatment were stimulated with Toll-like receptor (TLR) ligands to measure pro-inflammatory cytokine responses. Endoscopic biopsy samples before and after infliximab treatment were subjected to quantitative polymerase chain reaction.

Results: PBMCs from this CD-associated SpA patient exhibited higher production of pro-inflammatory cytokines upon stimulation with TLR ligands than PBMCs from healthy controls. Induction of remission by infliximab was associated with the downregulation of pro-inflammatory cytokine responses in the small intestinal mucosa, which is continually exposed to TLR ligands.

Conclusions: Excessive pro-inflammatory cytokine responses to TLR ligands might underlie the immunopathogenesis of CD-associated SpA.

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一例克罗恩病相关脊柱关节炎患者对 Toll 样受体配体的促炎细胞因子反应增强。

背景：尽管脊柱关节炎（Spondyloarthritis，SpA）作为克罗恩病（Crohn's disease，CD）肠道外表现的发病率很高，但CD相关性SpA的免疫发病机制在很大程度上仍然未知：我们试图探究一名成功接受英夫利昔单抗治疗的患者发生CD相关性SpA的分子机制：方法：用Toll样受体（TLR）配体刺激英夫利西单抗治疗前的外周血单核细胞（PBMC），以测量促炎细胞因子反应。对英夫利西单抗治疗前后的内镜活检样本进行定量聚合酶链反应：结果：与健康对照组相比，CD相关性SpA患者的白细胞在TLR配体刺激下产生的促炎细胞因子更高。英夫利昔单抗诱导病情缓解与小肠粘膜的促炎细胞因子反应下调有关，而小肠粘膜持续暴露于TLR配体：结论：对 TLR 配体的过度促炎细胞因子反应可能是 CD 相关性 SpA 免疫发病机制的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific journal of allergy and immunology 医学-过敏

CiteScore

12.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.