Cannabis and Vulvodynia Symptoms: A Preliminary Report.

Eliza Barach, Melissa N Slavin, Mitch Earleywine
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引用次数: 8

Abstract

Medical marijuana has a long history of use as an analgesic for chronic pain disorders, including dyspareunia (pain during intercourse), a hallmark of the rare chronic pain disorder vulvodynia. Many women's health topics remain under investigated. Few studies address cannabis's potential to treat vulvodynia symptoms despite their dramatic impact on quality of life. Women who had used cannabis and who reported experiencing vulvodynia symptoms (N = 38) completed an online survey assessing symptoms, expectancies regarding cannabis-associated relief from vulvodynia symptoms, cannabis use, and cannabis-related problems. Generally, women expected cannabis to have moderate to large effects on vulvodynia symptoms (d = .63-1.19). Nevertheless, women expected greater relief for burning/stabbing pain than for itching and pain associated with tampon insertion, as well greater relief for dyspareunia than for pain associated with tampon insertion. Those whose symptoms were worse expected more relief from cannabis treatment. Expectations of cannabis-induced relief did not increase frequency of use or problems. These data support the idea that further work is warranted, including placebo-controlled randomized clinical trials to rule out any placebo effects and identify potential adverse side effects from a cannabis treatment for vulvodynia.

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大麻和外阴痛症状:初步报告。
医用大麻作为慢性疼痛障碍的镇痛药有很长的历史,包括性交困难(性交痛),这是一种罕见的慢性疼痛障碍外阴痛的标志。许多妇女健康问题仍在调查之中。很少有研究涉及大麻治疗外阴痛症状的潜力,尽管它们对生活质量产生了巨大影响。使用过大麻并报告有外阴痛症状的妇女(N = 38)完成了一项在线调查,评估症状、大麻相关的外阴痛症状缓解预期、大麻使用和大麻相关问题。一般来说,妇女期望大麻对外阴痛症状有中等到较大的影响(d = 0.63 -1.19)。然而,与插入卫生棉条相关的瘙痒和疼痛相比,女性期望对灼烧/刺痛的缓解更大,对性交困难的缓解也比插入卫生棉条相关的疼痛更大。那些症状更严重的人期望从大麻治疗中得到更多的缓解。期望大麻引起的缓解并没有增加使用频率或问题。这些数据支持进一步研究的观点,包括安慰剂对照随机临床试验,以排除任何安慰剂效应,并确定大麻治疗外阴痛的潜在不良副作用。
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