Dosimetric comparison of Gamma Knife® Icon^TM and linear accelerator-based fractionated stereotactic radiotherapy (FSRT) plans for the re-irradiation of large (>14 cm³) recurrent glioblastomas.

IF 0.8 Q4 SURGERY Journal of radiosurgery and SBRT Pub Date : 2021-01-01

Matthew E Schelin, Haisong Liu, Ayesha Ali, Wenyin Shi, Yan Yu, Karen E Mooney

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引用次数: 0

Abstract

Our objective is to investigate dosimetric differences between clinically deliverable Gamma Knife^® (GK) Icon™ and linac-based FSRT plans on the basis of normal brain dose sparing for large (>14 cm³) recurrent glioblastomas (GBM). Sixteen patients with large, recurrent GBM were treated using re-irradiation via linac-based FSRT, 35 Gy in 10 fractions. For each patient, a new GK FSRT plan was created in Leksell GammaPlan^® V11 (LGP). To maintain clinical deliverability, the LGP optimization included a planning goal of treatment time <20 minutes per fraction. Dosimetric comparison of coverage and normal brain dose between the linac and GK treatment plans was performed in MIM. The GK FSRT plans had significantly (p < 0.05) lower mean normal brain dose values (-8.85%), mean values of normal brain V20 (-32.4%) and V12 (-25.9%), and a lower mean V4 (-10.0%). GK FSRT plans have the potential to reduce the risk of radiation-related toxicities.

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伽玛刀®IconTM和基于线性加速器的分割立体定向放疗(FSRT)计划对大(>14 cm3)复发性胶质母细胞瘤再照射的剂量学比较

我们的目的是研究临床可交付的伽玛刀(GK) Icon™和基于linac的FSRT计划在正常脑剂量节约的基础上对大(>14 cm3)复发性胶质母细胞瘤(GBM)的剂量差异。16例复发性大GBM患者采用基于linacs的FSRT再照射治疗，每次35 Gy，分10次。对于每位患者，在Leksell GammaPlan®V11 (LGP)中创建了新的GK FSRT计划。为了保持临床可交付性，LGP优化包括治疗时间的计划目标

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of radiosurgery and SBRT SURGERY-

CiteScore

1.40

自引率

8.30%

发文量