Central Serous Chorioretinopathy Analyzed by Multimodal Imaging.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY Translational Vision Science & Technology Pub Date : 2021-01-08 eCollection Date: 2021-01-01 DOI:10.1167/tvst.10.1.15

Liang Han, Jose Ronaldo Lima de Carvalho, Rait Parmann, Tongalp H Tezel, Stanley Chang, Tarun Sharma, Janet R Sparrow

{"title":"Central Serous Chorioretinopathy Analyzed by Multimodal Imaging.","authors":"Liang Han, Jose Ronaldo Lima de Carvalho, Rait Parmann, Tongalp H Tezel, Stanley Chang, Tarun Sharma, Janet R Sparrow","doi":"10.1167/tvst.10.1.15","DOIUrl":null,"url":null,"abstract":"Purpose: We correlated quantitative fundus autofluorescence (qAF) with other fundus features in patients exhibiting central serous chorioretinopathy (CSC).Methods: Short wavelength fundus autofluorescence (SW-AF, 488 nm excitation) was measured by qAF. Using nonnormalized images qAF values were calculated within eight concentric segments (qAF8) located at an eccentricity of 7° to 9°. Horizontal spectral domain optical coherence tomography (SD-OCT) scans and near-infrared fundus autofluorescence images (NIR-AF) were studied.Results: Thirty-six eyes of 20 patients (mean age 48.7± 8.5 years) diagnosed with CSC were studied. Thirteen patients had bilateral disease; four patients were female. In 22 eyes CSC was present in the macula; in one eye the lesion was in a peripapillary location, 10 involved both locations, and three were unaffected. Serous retinal detachment, retinal pigmented epithelial detachment (PED), outer retinal atrophy and subRPE hypertransmission were all features identifiable by SD-OCT. NIR-AF images were helpful in detecting foveal and parafoveal lesions. Sampling for retina-wide elevations in SW-AF intensity by measuring qAF8 did not indicate a generalizable relationship amongst CSC-diagnosed eyes. However, color-coded qAF images revealed alterations in SW-AF topography and intensity relative to healthy eyes at the same locations. Thus zones of higher than normal qAF intensity were found in association with SD-OCT detectable PED; loss of ellipsoid zone and interdigitation zone; and hyperreflectivity in outer retina. Pronounced decreases in qAF colocalized with serous retinal detachment and with outer retinal degeneration that included hypertransmission of SD-OCT signal into the choroid.Conclusions: Localized elevations in qAF reflect increased bisretinoid in association with CSC lesions.Translational relevance: Foci of elevated qAF at some stages of CSC contribute to the natural history of the disease.","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":" ","pages":"15"},"PeriodicalIF":2.6000,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/f9/tvst-10-1-15.PMC7804571.pdf","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Vision Science & Technology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/tvst.10.1.15","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 6

Abstract

Purpose: We correlated quantitative fundus autofluorescence (qAF) with other fundus features in patients exhibiting central serous chorioretinopathy (CSC).

Methods: Short wavelength fundus autofluorescence (SW-AF, 488 nm excitation) was measured by qAF. Using nonnormalized images qAF values were calculated within eight concentric segments (qAF₈) located at an eccentricity of 7° to 9°. Horizontal spectral domain optical coherence tomography (SD-OCT) scans and near-infrared fundus autofluorescence images (NIR-AF) were studied.

Results: Thirty-six eyes of 20 patients (mean age 48.7± 8.5 years) diagnosed with CSC were studied. Thirteen patients had bilateral disease; four patients were female. In 22 eyes CSC was present in the macula; in one eye the lesion was in a peripapillary location, 10 involved both locations, and three were unaffected. Serous retinal detachment, retinal pigmented epithelial detachment (PED), outer retinal atrophy and subRPE hypertransmission were all features identifiable by SD-OCT. NIR-AF images were helpful in detecting foveal and parafoveal lesions. Sampling for retina-wide elevations in SW-AF intensity by measuring qAF₈ did not indicate a generalizable relationship amongst CSC-diagnosed eyes. However, color-coded qAF images revealed alterations in SW-AF topography and intensity relative to healthy eyes at the same locations. Thus zones of higher than normal qAF intensity were found in association with SD-OCT detectable PED; loss of ellipsoid zone and interdigitation zone; and hyperreflectivity in outer retina. Pronounced decreases in qAF colocalized with serous retinal detachment and with outer retinal degeneration that included hypertransmission of SD-OCT signal into the choroid.

Conclusions: Localized elevations in qAF reflect increased bisretinoid in association with CSC lesions.

Translational relevance: Foci of elevated qAF at some stages of CSC contribute to the natural history of the disease.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

中枢性浆液性脉络膜视网膜病变的多模态影像学分析。

目的:我们将定量眼底自身荧光(qAF)与中枢性浆液性脉络膜视网膜病变(CSC)患者的其他眼底特征联系起来。方法:用qAF法测定短波眼底自体荧光(SW-AF，激发488nm)。利用非归一化图像计算偏心距为7°~ 9°的8个同心段(qAF8)内的qAF值。研究了水平光谱域光学相干断层扫描(SD-OCT)和近红外眼底自体荧光成像(NIR-AF)。结果:对20例确诊为CSC的患者36只眼(平均年龄48.7±8.5岁)进行了研究。双侧病变13例;4例为女性。22只眼黄斑存在CSC;1只眼睛病变位于乳头周围，10只同时累及两个位置，3只未受影响。浆液性视网膜脱离、视网膜色素上皮脱离(PED)、视网膜外萎缩和subpe超透射均为SD-OCT可识别的特征。NIR-AF图像有助于检测中央凹和中央凹旁病变。通过测量qAF8进行全视网膜范围内SW-AF强度升高的采样，并不能表明csc诊断的眼睛之间存在普遍的关系。然而，彩色编码的qAF图像显示，在相同的位置，相对于健康的眼睛，SW-AF的形貌和强度发生了变化。因此，高于正常qAF强度的区域与SD-OCT可检测到的PED相关;椭球带和指间带的损失;外视网膜的高反射率。qAF的明显下降与浆液性视网膜脱离和视网膜外变性(包括SD-OCT信号超传递到脉络膜)同时发生。结论:qAF的局部升高反映了类双维甲酸增加与CSC病变相关。翻译相关性:在CSC的某些阶段qAF升高的焦点有助于疾病的自然史。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.