A retrospective analysis of the effect of the intervention of Arogya Kashayam in COVID-19 positive cases in Madhya Pradesh.

Ayu Pub Date : 2019-10-01 Epub Date: 2021-01-14 DOI:10.4103/ayu.ayu_365_20
Umesh Shukla, Sanjay Srivastava, Pankaj Gupta, Nitin Ujjaliya
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引用次数: 3

Abstract

Introduction: Coronavirus disease (COVID-19) is a newly identified strain of corona virus that causes illness ranging from the clinical features similar to the common cold to a fatal condition due to severe respiratory failure. According to the WHO, there have been more than 26.3 million confirmed COVID-19 cases in more than 190 countries to date. In light of the outbreak, various treatment modalities have been considered, including traditional medicine, which has been widely used in the pandemic of severe acute respiratory syndrome (SARS) and H1N1 influenza. Ayurveda contributes a measurable ratio in the world's traditional practices. As per the guideline of directorate of AYUSH, Government of Madhya Pradesh, cases of COVID-19 were intervened with Arogya Kashayam (AK-20), a decoction prepared from the herbs at 88 COVID Care Centers (CCC) across the state.

Aim: To evaluate retrospectively, the effect of the intervention of AK-20 in COVID-19 positive cases as stand alone or in combination with hydroxychloroquine (HCQ) administered at CCC in Madhya Pradesh.

Materials and methods: It is a retrospective study with 4432 COVID-19 reverse transcription-polymerase chain reaction (RTPCR) tested positive cases including 2750 males and 1682 females between 5 and 80 years of age. All the cases were intervened with AK-20 as stand alone or in combination with HCQ. Moreover, these patients were also given Zinc and Vitamin C simultaneously. The intervention of AK-20 was made through the district level government AYUSH machinery, and the related data were collected in specially designed case report form. The data were analyzed retrospectively, and outcomes included the RTPCR testing or asymptomatic discharge from the CCC as per the prevailing ICMR guidelines.

Results: The present study reveals that out of 4432 COVID-19 RTPCR-positive cases, 2817 (63.56%) received HCQ with AK-20 and 1615 cases (36.43%) received AK-20 as a stand alone treatment. Among the cases that received HCQ and AK-20, 2681 cases (94.17%) recovered completely in an average of 6.8 days and among those who were on standalone AK-20, 1502 cases (93.00%) recovered completely in the same average days. The Chi-square test showed that both the groups were equally effective (P < 0.01; F = 0.3764).

Conclusion: The retrospective analysis showed that the treatment practices of AK-20 standalone or in combination with HCQ applied in COVID-19 positive cases at CCC in Madhya Pradesh were effective against SARS coronavirus 2 disease. A significant number of cases was tested negative or asymptomatically discharged from both the groups of interventions. Moreover, AK-20 alone has shown statistically equal results to that when used in combination with HCQ therapy.

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Arogya Kashayam对中央邦COVID-19阳性病例干预效果的回顾性分析
简介:冠状病毒病(COVID-19)是一种新发现的冠状病毒毒株,可引起各种疾病,从类似普通感冒的临床特征到严重呼吸衰竭导致的致命疾病。据世界卫生组织统计,迄今为止,在190多个国家已有2630多万例新冠肺炎确诊病例。鉴于疫情的爆发,考虑了各种治疗方式,包括在严重急性呼吸系统综合症(萨斯)和H1N1流感大流行中广泛使用的传统医学。阿育吠陀在世界传统实践中占有可衡量的比例。根据中央邦政府AYUSH局的指导方针,用Arogya Kashayam (AK-20)干预COVID-19病例,这是一种在全州88个COVID-19护理中心(CCC)用草药制备的煎剂。目的:回顾性评价AK-20单独或联合羟氯喹(HCQ)干预中央邦CCC COVID-19阳性病例的效果。材料与方法:对4432例新冠肺炎RTPCR检测阳性病例进行回顾性研究,其中男性2750例,女性1682例,年龄在5 ~ 80岁之间。所有病例均单独或联合使用AK-20进行干预。同时给予锌和维生素C。通过区级政府AYUSH机构对AK-20进行干预,并以专门设计的病例报告表收集相关数据。回顾性分析数据,结果包括RTPCR检测或根据现行ICMR指南从CCC无症状出院。结果:在4432例COVID-19 rtpcr阳性病例中,2817例(63.56%)采用HCQ联合AK-20治疗,1615例(36.43%)单独使用AK-20治疗。在服用HCQ和AK-20的病例中,2681例(94.17%)在平均6.8 d内完全康复;在单独服用AK-20的病例中,1502例(93.00%)在相同的平均6.8 d内完全康复。卡方检验显示两组疗效相当(P < 0.01;F = 0.3764)。结论:回顾性分析表明,中央邦CCC对COVID-19阳性病例单独使用AK-20或联合使用HCQ治疗SARS冠状病毒2型疾病是有效的。两组干预措施中均有相当数量的病例检测呈阴性或无症状出院。此外,AK-20单独使用与HCQ联合使用的结果在统计上是相等的。
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