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Introduction: Agad Tantra being the unique branch that deals with toxicology and its management enlists several antitoxic drugs used for various poisonings. Ancient texts comprise the list of a wide range of traditional medicines, but they are not explored due to lack of incomprehension.

Aims: The review has been written with the aim to dig out the hidden knowledge of Vishaghna Dravyas (alexeterics) mentioned in Kaiydeva Nighantu.

Materials and methods: This Nighantu was written in the 15^th century A. D. by Kaiydeva with the name "Pathya-Apathya-Vibodhaka" it comprising of total 514 Dravyas out of which 175 drugs possess Vishagna (anti-poisonous) property.

Results: These Vishaghna Dravyas (alexeterics) have been distributed based on various Vargas (classes) which is described as 121 belonging to Ausghada Varga (drug class) as single drugs and four as groups, total of 16 from Dhatu Varga (metal class) as single drugs and one as compound or as a group, 9 from Dhanya Varga (cereal class) as a single drug, 15 in Dravya Varga as single drugs, and 5 as compound or as a group. Two each in Kritana Varga and Vihara Varga and one in Mansa Varga as compound or as a group. Out of all the 175 Vishagna Dravayas (alexeterics), 18 Dravyas (substances) are specific indications in combating particular types of envenomation or poisoning conditions.

Conclusion: All the abovementioned drugs are screened for the purpose of revalidation to bring out their therapeutic utility.

Background: The prevalence of type 2 diabetes (T2D) has increased substantially in the past few decades throughout the world. In India, the epidemic of diabetes continues to increase irrespective of area, status, and age. Despite various scientific societies involved in the treatment of diabetes, still, the burden of diabetes keeps growing.

Aims: The aim of this work is to explore the Ayurvedic concept of a personalized diet to modulate the gut microbiota for the treatment of T2D.

Material and methods: A thorough study of literature from online scientific databases including Web of Science, PubMed, Scopus, and Google Scholar as well as from classical texts of Ayurveda was done. A careful compilation was done to extract the valuable output of the personalized diet to modulate the gut microbiota.

Results: There are various diets used to control blood glucose levels, and their effects are also being studied on the transcriptome or epigenome despite 99.9% genomic similarity among human beings. However, microbiomes have only 10% similarity. Ayurvedic diet is given on the basis of Prakriti (body constitution), therefore, it is also called personalized diet.

Conclusion: The diets prescribed for T2D in Ayurveda are high in fibers, polyphenols, and complex carbohydrates which enrich butyrate-producing bacteria and decrease lipopolysaccharide-producing bacteria. Hence, there is a need to have a personalized diet to manage the glucose level by enriching beneficial gut microbiota. The approach of a personalized diet associated with gut microbiota can be helpful in maintaining blood sugar in T2D patients.

Background: Gouania longipetala Hemsl. is a scandent shrub used in traditional medicine for the management of different ailments such as gout, female infertility, heart diseases, diabetes, and malaria. Pathophysiology of the diseases is generally associated with oxidative stress. Antioxidant properties of G. longipetala have not yet been well elucidated.

Aims: This study aimed to evaluate the antioxidant content and antioxidant activity of methanol extracts from the plant's stems and leaves.

Materials and methods: Methanol extracts from the plant stems and leaves were screened for phytochemical components with antioxidant properties (Vitamin C, total phenolics, and flavonoids). The antioxidant reducing power of the extracts as well as its effects on lipid peroxidation and catalase were also evaluated in vitro using biochemical assays.

Results: Leaf extract was richer than stem extract in different antioxidants such as Vitamin C, phenolics, and flavonoids. Both leaf and stem extracts showed similar inhibitory effect on lipid peroxidation and stimulatory effect on catalase activity, while leaf extract had higher ferric antioxidant effect than stem extract.

Conclusion: Both extracts from G. Longipetala possessed antioxidant content, though activities with leaf extract displayed higher antioxidant properties than stem extract.

Background: Water is vital for life as the body uses water in all its cells and tissues to maintain vital functions. Hence, water used for drinking should be free from all types of impurities. Acharya Sushruta has mentioned various water purification methods by keeping it in different types of vessels (silver, copper, and clay) and by adding herbs such as Kataka Beeja (seeds Strychnos potatorum Linn.). With urbanization, there are changes in the lifestyle of individuals and their food habits. Therefore, based on the ease of availability of materials, storage of water needs to be analyzed by simple parameters such as total dissolved solutes (TDS) that comprises inorganic salts such as bicarbonates, sulfates, and chlorides and a small amount of organic matter that is dissolved in water. A high level of TDS indicates water is unfit for consumption and may lead to nausea, vomiting, dizziness, etc., TDS level indicates whether water is suitable for consumption or it requires filtration.

Aim: To evaluate and compare the TDS of water kept for 24 h in different vessels made up of silver, copper, clay, plastic, and steel and further with the addition of different herbs like Kataka seeds, Tulsi leaves (Ocimum tenuiflorum Linn.), Nimba leaves (Azadirachta indica A. Juss) separately in different vessels.

Materials and methods: The effect of different materials used for storage of water was assessed by evaluating TDS in water samples with the help of a well-calibrated TDS meter, on stored water (100 ml) in different types of vessels (silver, copper, clay, plastic, and steel) and further with the addition of different herbs (10 g) Kataka seeds, Tulsi leaves and Nimba leaves individually and separately, by keeping undisturbed for 24 h.

Results: TDS values of the water samples kept for 24 h in different vessels, i.e., silver, copper, plastic, steel, and clay are 372, 429, 436, 445, 628 ppm, respectively, were found.

Conclusion: The silver vessel was found to be best in decreasing the TDS value of water among vessels. On evaluating additional effects by adding different herbs, Nimba showed its action best among the storage vessels.

Background: Various root canal filling materials are used to preserve pulp tissue involved carious the primary tooth. A single material that fulfills all the requirements of an ideal root canal filling material for primary teeth is yet unavailable. Hence, this study was initiated to evaluate clinically and radiographically, the efficacy of two obturating materials - zinc oxide eugenol (ZOE) and zinc oxide mixed with Neem oil (ZON) for 12 months.

Aims: To assess the success rate of a mixture of zinc oxide and neem oil in comparison to zinc oxide-eugenol paste, as an obturating material in primary molars. To compare the efficacy of ZON as an obturating material at the various time interval of 3, 6, 9, and 12 months postoperatively.

Materials and methods: This split-mouth, double-blind study was performed on 24 children aged 5-7 years, who presented with bilaterally infected primary molars. Total 48 infected primary molars were divided into two groups for pulpectomy followed by obturation with ZOE and ZON, respectively. Randomization with the chit-pick method, for the control and experimental drug, was performed. A follow-up for 12 months was performed. The Chi-square test was used for inter-group comparison and the Z test was used for the analysis of data over a period of time.

Results: Overall clinical findings in this study revealed 91.7% results in ZOE compared with 100% results in the ZON group. The radiographical findings revealed 91.7% results in ZOE compared with 100% success in the ZON group.

Conclusion: ZON demonstrated excellent effectiveness as an obturating material in the 12-month follow-up period as compared to ZOE in primary teeth. The efficacy elicited in this study could be a basis to recommend ZON as herbal alternative obturation material.

Hepatitis B is one of the most common causes of liver disease, and due to unawareness of the safety measures, more prone to spread. As per the World Health Organization, for the South East Asia region, its prevalence is 2%. Yellowish discoloration of the eyes, body, and urine, abdominal discomfort, and vomiting is its cardinal symptoms. In Ayurveda, this set of symptoms is known as Kamala. This case report illustrates the effectiveness of the Ayurveda treatment modality in a patient with a viral load of 3705.71 IU/ml, and the values of AST (aspartate aminotransferase) and alanine transaminase (ALT) were 140 IU/ml and 173 IU/ml, respectively. A 40-year-old female patient with a complaint of yellowish discoloration of urine, eyes, and skin with fatigue and irritability was diagnosed with Ubhayapatha Ashrita Swatantra Kamala. The patient was treated with Ayurveda drugs and Virechana Karma (therapeutic purgation). After the treatment for 13 months, the disease was cured. Improvement was observed based on hepatitis B virus deoxyribonucleic acid (DNA) polymerase chain reaction (PCR) (hepatitis B DNA PCR) (decreased from 3705.71 IU/ml to <50.0 IU/ml) and the values of AST (decreased from 140 IU/ml to 19.0 IU/ml) and ALT (decreased from 173 IU/ml to 28 IU/ml). The patient was stable and asymptomatic during the follow-up period of 4 months.