More severe hypercoagulable state in acute COVID-19 pneumonia as compared to other pneumonia.

Mayo Clinic Proceedings: Innovations, Quality & Outcomes Pub Date : 2021-04-12 DOI:10.1016/j.mayocpiqo.2020.08.014

Luca Spiezia, Elena Campello, Marco Cola, Francesco Poletto, Lorenzo Cerruti, Anna Poretto, Chiara Simion, Annamaria Cattelan, Roberto Vettor, Paolo Simioni

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Abstract

Objective: To conduct a comprehensive evaluation of coagulation profiles - via traditional and whole blood thromboelastometry tests - in COVID-19 positive vs. COVID-19 negative patients admitted to medical wards for acute pneumonia.

Patients and methods: We enrolled all consecutive patients admitted to Internal Medicine wards of Padova University Hospital between 7 March and 30 April 2020 for COVID-19-related pneumonia (cases) vs. non-COVID-19 pneumonia (controls). A group of healthy subjects acted as baseline for thromboelastometry parameters.

Results: Fifty-six cases (mean age 64±15 yrs, M/F 37/19) and 56 controls (mean age 76±11 yrs, M/F 35/21) were enrolled. Cases and controls showed markedly hypercoagulable thromboelastometry profiles vs. healthy subjects, mainly characterized by a significantly shorter propagation phase of coagulation (Clot Formation Time, CFT) and significantly increased maximum clot firmness (MCF) (p <0.001 in all comparisons). COVID-19 patients with pneumonia had significantly shorter CFT and higher MCF (p <0.01 and <0.05, respectively in all comparisons) vs. controls.

Conclusion: Patients admitted to internal medicine wards for COVID-19 pneumonia presented a markedly prothrombotic state, which seems peculiar to COVID-19 rather than pneumonia itself.

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与其他肺炎相比，COVID-19 急性肺炎的高凝状态更为严重。

目的对因急性肺炎入住内科病房的COVID-19阳性与COVID-19阴性患者的凝血功能进行全面评估（通过传统和全血血栓弹力检测）：我们招募了 2020 年 3 月 7 日至 4 月 30 日期间因 COVID-19 相关肺炎（病例）与非 COVID-19 肺炎（对照）入住帕多瓦大学医院内科病房的所有连续患者。一组健康受试者作为血栓弹性测量参数的基线：56例病例（平均年龄64±15岁，男/女37/19）和56例对照组（平均年龄76±11岁，男/女35/21）。与健康受试者相比，病例和对照组的血栓弹性测定均显示出明显的高凝状态，主要特征是凝血的传播阶段（凝血形成时间，CFT）明显缩短，最大凝块坚固度（MCF）明显增加（p 结论：血栓弹性测定显示出的高凝状态与健康受试者相比，主要特征是凝血的传播阶段（凝血形成时间，CFT）明显缩短，最大凝块坚固度（MCF）明显增加：因 COVID-19 肺炎入住内科病房的患者出现了明显的血栓前状态，这似乎是 COVID-19 而非肺炎本身所特有的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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