Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems.

IF 3.6 3区 化学 Q2 CHEMISTRY, ANALYTICAL Reviews in Analytical Chemistry Pub Date : 2020-01-01 Epub Date: 2020-12-31 DOI:10.1515/revac-2020-0117
Juan M Rojas Cabrera, J Blair Price, Aaron E Rusheen, Abhinav Goyal, Danielle Jondal, Abhijeet S Barath, Hojin Shin, Su-Youne Chang, Kevin E Bennet, Charles D Blaha, Kendall H Lee, Yoonbae Oh
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Abstract

Neurochemical recording techniques have expanded our understanding of the pathophysiology of neurological disorders, as well as the mechanisms of action of treatment modalities like deep brain stimulation (DBS). DBS is used to treat diseases such as Parkinson's disease, Tourette syndrome, and obsessive-compulsive disorder, among others. Although DBS is effective at alleviating symptoms related to these diseases and improving the quality of life of these patients, the mechanism of action of DBS is currently not fully understood. A leading hypothesis is that DBS modulates the electrical field potential by modifying neuronal firing frequencies to non-pathological rates thus providing therapeutic relief. To address this gap in knowledge, recent advances in electrochemical sensing techniques have given insight into the importance of neurotransmitters, such as dopamine, serotonin, glutamate, and adenosine, in disease pathophysiology. These studies have also highlighted their potential use in tandem with electrophysiology to serve as biomarkers in disease diagnosis and progression monitoring, as well as characterize response to treatment. Here, we provide an overview of disease-relevant neurotransmitters and their roles and implications as biomarkers, as well as innovations to the biosensors used to record these biomarkers. Furthermore, we discuss currently available neurochemical and electrophysiological recording devices, and discuss their viability to be implemented into the development of a closed-loop DBS system.

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神经化学测量的进展:用于开发闭环深部脑刺激系统的生物标记物和设备综述。
神经化学记录技术拓展了我们对神经系统疾病的病理生理学以及脑深部刺激(DBS)等治疗方式的作用机制的了解。DBS 用于治疗帕金森病、抽动秽语综合征和强迫症等疾病。虽然 DBS 能有效缓解这些疾病的相关症状并改善患者的生活质量,但目前人们对 DBS 的作用机制还不完全清楚。一个主要的假设是,DBS 通过将神经元的发射频率调整为非病理性频率来调节电场电位,从而提供治疗缓解。针对这一知识空白,电化学传感技术的最新进展让人们了解到多巴胺、血清素、谷氨酸和腺苷等神经递质在疾病病理生理学中的重要性。这些研究还突显了它们与电生理学结合使用的潜力,可作为生物标记物用于疾病诊断和进展监测,以及描述对治疗的反应。在此,我们将概述与疾病相关的神经递质及其作为生物标记物的作用和意义,以及用于记录这些生物标记物的生物传感器的创新。此外,我们还讨论了目前可用的神经化学和电生理记录设备,并讨论了将这些设备应用到闭环 DBS 系统开发中的可行性。
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来源期刊
Reviews in Analytical Chemistry
Reviews in Analytical Chemistry 化学-分析化学
CiteScore
7.50
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.
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