What's new in chronic pain pathophysiology.

Ivan Cohen, Mark J Lema
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引用次数: 2

Abstract

The understanding of pain pathophysiology is continuously evolving. Identifying underlying cellular and subcellular pathways helps create opportunities for targeted therapies that may prove to be effective interventions. This article is an update on four areas of developing knowledge as it pertains to clinical management of patients with pain: nerve growth factor antagonists, microglial modulation, AMP-activated protein kinase activators, and genetic pain factors. Each of these areas represents novel targets for targeted therapies to prevent, treat, and modify the disease course of acute, chronic, and neuropathic pain. Currently most pain management techniques do not target these pathways directly, but there is promising evidence to suggest that the field is advancing toward available therapies in the near future.

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慢性疼痛病理生理学有什么新进展?
对疼痛病理生理的认识在不断发展。识别潜在的细胞和亚细胞途径有助于为靶向治疗创造机会,这些治疗可能被证明是有效的干预措施。这篇文章是关于发展知识的四个领域的更新,因为它涉及到临床管理的疼痛患者:神经生长因子拮抗剂,小胶质细胞调节,amp激活的蛋白激酶激活剂和遗传疼痛因素。这些领域中的每一个都代表了靶向治疗的新靶点,以预防、治疗和改变急性、慢性和神经性疼痛的病程。目前,大多数疼痛管理技术并没有直接针对这些途径,但有希望的证据表明,该领域在不久的将来将朝着可用的治疗方法发展。
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来源期刊
CiteScore
3.70
自引率
12.50%
发文量
36
期刊最新文献
Prospective Preference Assessment for the Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN (PEACE-PAIN) Trial. Assessing Quality of Referrals to a Community-Based Chronic Pain Clinic. The Influence of Loneliness on Pain Outcomes for Adolescents: A Cross-Sectional Survey. Chronic pain experiences of immigrant Indian women in Canada: A photovoice exploration. [Enhancing Chronic Pain Management: Exploring the Essential Contribution of Primary Care Nurses].
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