A stochastic compartmental model to simulate the Covid-19 epidemic spread on a simple network.

IF 1.5 4区 生物学 Q4 Agricultural and Biological Sciences Theoretical Biology Forum Pub Date : 2020-01-01 DOI:10.19272/202011402004
Armando Bazzani, Enrico Lunedei, Sandro Rambaldi
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引用次数: 1

Abstract

The recent Covid-19 epidemic has pointed out the inadequacy of the plans applied by industrial countries to limit the epidemic spread and frailty of the global economy to cope with a pandemic. Many countries were forced to a global lockdown with a great socio-economic impact. In Italy, one of the problems was the complex mobility network structure of the Northern regions that made ineffective the attempts to isolate the initial hotspots. In the paper we study a simple model that simulates the epidemic spread on a community network that may exchange population according to a daily mobility rate. In each community the epidemic evolution is provided by a stochastic compartmental model whose parameters are tuned to reproduce the Covid-19 evolution observed in Italy before the global lockdown policies. We initially study the delay in the epidemic spread due to the finite local mobility by proposing a power law relation for the increasing of the infection peak time in each node and the network distance from the initial node where the epidemic starts. We consider two scenarios to study the effectiveness of local lockdown policies: the presence of two clusters weakly connected by the mobility or a homogeneous chain of communities that exchange the population at a fixed rate. In both cases we show the existence of a threshold effect, in a probabilistic sense, for the effectiveness of lockdown policies as a function of the delay time at which such policies are applied, or of the network distance from the outbreak node.

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一个模拟Covid-19流行病在简单网络上传播的随机区室模型。
最近的新冠肺炎疫情表明,发达国家限制疫情传播的计划存在不足,全球经济应对大流行的能力也很薄弱。许多国家被迫实施全球封锁,造成巨大的社会经济影响。在意大利,问题之一是北部地区复杂的交通网络结构,使得隔离最初热点的尝试无效。在本文中,我们研究了一个简单的模型,该模型模拟了流行病在一个社区网络上的传播,该社区网络可以根据每日流动率交换人口。在每个社区,流行病的演变由一个随机区隔模型提供,该模型的参数经过调整,以重现在全球封锁政策之前在意大利观察到的Covid-19演变。通过建立各节点感染高峰时间与网络距离的幂律关系,初步研究了由于局部流动性有限导致的传染病传播延迟问题。我们考虑了两种情况来研究地方封锁政策的有效性:存在两个由流动性弱连接的集群,或者存在以固定速率交换人口的同质社区链。在这两种情况下,我们在概率意义上表明,对于应用此类策略的延迟时间或与爆发节点的网络距离有关的锁定策略有效性,存在阈值效应。
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来源期刊
Theoretical Biology Forum
Theoretical Biology Forum 生物-生物学
CiteScore
0.70
自引率
0.00%
发文量
0
审稿时长
>12 weeks
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