Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2021-12-01 DOI:10.1080/19336918.2021.1921402

Luying Li, Youping Jin, Xue Wang, Li Wang, Yangbai Sun, Yihong Luo, Xiaojian Ni, Qi Lu, Wenbo Wei, Xiuling Zhi, Jerry Yu, Wei Zhu, Ping Zhou

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引用次数: 2

Abstract

LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of ENST00000508435 was positively correlated with tumor size, lymph node metastasis and HER2. More interesting, overexpression of ENST00000508435 significantly increased cell migration, while specific knockdown led to the opposite. RNA pull-down and RNA immunoprecipitation assays demonstrated that ENST00000508435 could directly bind to FXR1 to promote tumor metastasis. ENST00000508435 and FXR1 were positively correlated. FXR1 was also significantly up-regulated in breast tumors. Taken together, we propose that ENST00000508435 regulates FXR1 to promote breast cancer metastasis.

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长链非编码RNA ENST00000508435通过fxr1促进乳腺癌迁移

LncRNA在肿瘤进展中起关键作用。然而，它在乳腺癌中的作用仍不清楚。在这里，我们报道了一个新发现的lncRNA, ENST00000508435，它可以在乳腺癌细胞和组织中显著上调。我们发现ENST00000508435的表达与肿瘤大小、淋巴结转移和HER2呈正相关。更有趣的是，过表达ENST00000508435显著增加细胞迁移，而特异性敲低则相反。RNA拉下和RNA免疫沉淀实验表明，ENST00000508435可直接结合FXR1促进肿瘤转移。ENST00000508435与FXR1呈正相关。FXR1在乳腺肿瘤中也显著上调。综上所述，我们提出ENST00000508435调控FXR1促进乳腺癌转移。

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